Abstract：
:Mucosal antigens induce generation of lamina propria plasma cells (PCs) that secrete dimeric immunoglobulin A (IgA) destined for transport across the epithelium. In addition, blood contains monomeric IgA. To study the relationship between mucosal and systemic antibody responses, we took advantage of celiac disease patient samples for isolation of gut PCs as well as serum IgA and IgG reactive with a gluten-derived peptide or the autoantigen transglutaminase 2. Proteomic analysis of serum IgA revealed antigen-specific V-gene preferences, which matched those found in gut PCs. Further, gut PC CDR-H3 sequences were abundant in serum IgA but also detectable in serum IgG. Our data indicate that the same B cell clones that give rise to gut PCs also contribute to the serum antibody pool. However, serum IgA antibodies had a molecular composition distinct from that of IgA antibodies secreted in the gut, suggesting that individual B cell clones give rise to different PC populations.
journal_name
Cell Repjournal_title
Cell reportsauthors
Iversen R,Snir O,Stensland M,Kroll JE,Steinsbø Ø,Korponay-Szabó IR,Lundin KEA,de Souza GA,Sollid LMdoi
10.1016/j.celrep.2017.08.036subject
Has Abstractpub_date
2017-09-05 00:00:00pages
2357-2367issue
10issn
2211-1247pii
S2211-1247(17)31143-9journal_volume
20pub_type
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