Abstract：
:Impulses generated by a multicellular, bioelectric signaling center termed the sinoatrial node (SAN) stimulate the rhythmic contraction of the heart. The SAN consists of a network of electrochemically oscillating pacemaker cells encased in a heterogeneous connective tissue microenvironment. Although the cellular composition of the SAN has been a point of interest for more than a century, the biological processes that drive the tissue-level assembly of the cells within the SAN are unknown. Here, we demonstrate that the SAN's structural features result from a developmental process during which mesenchymal cells derived from a multipotent progenitor structure, the proepicardium, integrate with and surround pacemaker myocardium. This process actively remodels the forming SAN and is necessary for sustained electrogenic signal generation and propagation. Collectively, these findings provide experimental evidence for how the microenvironmental architecture of the SAN is patterned and demonstrate that proper cellular arrangement is critical for cardiac pacemaker biorhythmicity.
journal_name
Cell Repjournal_title
Cell reportsauthors
Bressan M,Henley T,Louie JD,Liu G,Christodoulou D,Bai X,Taylor J,Seidman CE,Seidman JG,Mikawa Tdoi
10.1016/j.celrep.2018.04.075subject
Has Abstractpub_date
2018-05-22 00:00:00pages
2283-2291issue
8issn
2211-1247pii
S2211-1247(18)30634-Xjournal_volume
23pub_type
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