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Continued Bcl6 Expression Prevents the Transdifferentiation of Established Tfh Cells into Th1 Cells during Acute Viral Infection.

Abstract：

:T follicular helper (Tfh) cells are crucial for the establishment of germinal centers (GCs) and potent antibody responses. Nevertheless, the T cell-intrinsic factors that are required for the maintenance of already-established Tfh cells and GCs remain largely unknown. Here, we use temporally guided gene ablation in CD4+ T cells to dissect the contributions of the Tfh-associated chemokine receptor CXCR5 and the transcription factor Bcl6. Induced ablation of Cxcr5 has minor effects on the function of established Tfh cells, and Cxcr5-ablated cells still exhibit most of the features of CXCR5+ Tfh cells. In contrast, continued Bcl6 expression is critical to maintain the GC Tfh cell phenotype and also the GC reaction. Importantly, Bcl6 ablation during acute viral infection results in the transdifferentiation of established Tfh into Th1 cells, thus highlighting the plasticity of Tfh cells. These findings have implications for strategies that boost or restrain Tfh cells and GCs in health and disease.

journal_name

Cell Rep

journal_title

Cell reports

authors

Alterauge D,Bagnoli JW,Dahlström F,Bradford BM,Mabbott NA,Buch T,Enard W,Baumjohann D

doi

10.1016/j.celrep.2020.108232

subject

Has Abstract

pub_date

2020-10-06 00:00:00

pages

108232

issue

1

issn

2211-1247

pii

S2211-1247(20)31221-3

journal_volume

33

pub_type

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