Engineered Tumor-Targeted T Cells Mediate Enhanced Anti-Tumor Efficacy Both Directly and through Activation of the Endogenous Immune System.

abstract：:Metabolic reprogramming is a hallmark of clear cell renal cell carcinoma (ccRCC) progression. Here, we used genome-scale metabolic modeling to elucidate metabolic reprogramming in 481 ccRCC samples and discovered strongly coordinated regulation of glycosaminoglycan (GAG) biosynthesis at the transcript and protein leve...

journal_title：Cell reports

authors： Gatto F,Volpi N,Nilsson H,Nookaew I,Maruzzo M,Roma A,Johansson ME,Stierner U,Lundstam S,Basso U,Nielsen J

更新日期：2016-05-24 00:00:00

abstract：:Translation of mRNAs in dendrites mediates synaptic plasticity, the probable cellular basis of learning and memory. Coordination of translational inhibitory and stimulatory mechanisms, as well as dendritic transport of mRNA, is necessary to ensure proper control of this local translation. Here, we find that the deaden...

journal_title：Cell reports

authors： McFleder RL,Mansur F,Richter JD

更新日期：2017-07-18 00:00:00

abstract：:Evolutionary elaboration of tissues starts with changes in the genome and location of the stem cells. For example, GABAergic interneurons of the mammalian neocortex are generated in the ventral telencephalon and migrate tangentially to the neocortex, in contrast to the projection neurons originating in the ventricular...

journal_title：Cell reports

authors： Radonjić NV,Ayoub AE,Memi F,Yu X,Maroof A,Jakovcevski I,Anderson SA,Rakic P,Zecevic N

更新日期：2014-12-24 00:00:00

abstract：:Riboswitches are mRNA elements regulating gene expression in response to direct binding of a metabolite. While these RNAs are increasingly well understood with respect to interactions between receptor domains and their cognate effector molecules, little is known about the specific mechanistic relationship between meta...

journal_title：Cell reports

authors： Polaski JT,Holmstrom ED,Nesbitt DJ,Batey RT

更新日期：2016-05-03 00:00:00

abstract：:Neuropathic pain is a chronic debilitating disease that results from nerve damage, persists long after the injury has subsided, and is characterized by spontaneous pain and mechanical hypersensitivity. Although loss of inhibitory tone in the dorsal horn of the spinal cord is a major contributor to neuropathic pain, th...

journal_title：Cell reports

authors： Petitjean H,Pawlowski SA,Fraine SL,Sharif B,Hamad D,Fatima T,Berg J,Brown CM,Jan LY,Ribeiro-da-Silva A,Braz JM,Basbaum AI,Sharif-Naeini R

更新日期：2015-11-10 00:00:00

abstract：:Primary afferents transduce environmental stimuli into electrical activity that is transmitted centrally to be decoded into corresponding sensations. However, it remains unknown how afferent populations encode different somatosensory inputs. To address this, we performed two-photon Ca2+ imaging from thousands of dorsa...

journal_title：Cell reports

authors： Wang F,Bélanger E,Côté SL,Desrosiers P,Prescott SA,Côté DC,De Koninck Y

更新日期：2018-05-15 00:00:00

abstract：:Biomineralization of the extracellular matrix is an essential, regulated process. Inappropriate mineralization of bone and the vasculature has devastating effects on patient health, yet an integrated understanding of the chemical and cell biological processes that lead to mineral nucleation remains elusive. Here, we r...

journal_title：Cell reports

authors： Müller KH,Hayward R,Rajan R,Whitehead M,Cobb AM,Ahmad S,Sun M,Goldberga I,Li R,Bashtanova U,Puszkarska AM,Reid DG,Brooks RA,Skepper JN,Bordoloi J,Chow WY,Oschkinat H,Groombridge A,Scherman OA,Harrison JA,Verhulst

更新日期：2019-06-11 00:00:00

abstract：:Metazoan genomes are partitioned into modular chromosomal domains containing active or repressive chromatin. In flies, Polycomb group (PcG) response elements (PREs) recruit PHO and other DNA-binding factors and act as nucleation sites for the formation of Polycomb repressive domains. The sequence specificity of PREs i...

journal_title：Cell reports

authors： Schuettengruber B,Oded Elkayam N,Sexton T,Entrevan M,Stern S,Thomas A,Yaffe E,Parrinello H,Tanay A,Cavalli G

更新日期：2014-10-09 00:00:00

abstract：:The bacterial pathogen Listeria monocytogenes (Lm) capitalizes on natural killer (NK) cell production of regulatory interleukin (IL)-10 to establish severe systemic infections. Here, we identify regulators of this IL-10 secretion. We show that IL-18 signals to NK cells license their ability to produce IL-10. IL-18 act...

journal_title：Cell reports

authors： Clark SE,Schmidt RL,McDermott DS,Lenz LL

更新日期：2018-05-29 00:00:00

abstract：:Herein, we demonstrate that HCMV miR-UL112-5p targets ERAP1, thereby inhibiting the processing and presentation of the HCMV pp65495-503 peptide to specific CTLs. In addition, we show that the rs17481334 G variant, naturally occurring in the ERAP1 3' UTR, preserves ERAP1 from miR-UL112-5p-mediated degradation. Specific...

journal_title：Cell reports

authors： Romania P,Cifaldi L,Pignoloni B,Starc N,D'Alicandro V,Melaiu O,Li Pira G,Giorda E,Carrozzo R,Bergvall M,Bergström T,Alfredsson L,Olsson T,Kockum I,Seppälä I,Lehtimäki T,Hurme MA,Hengel H,Santoni A,Cerboni C,Locate

更新日期：2017-07-25 00:00:00

abstract：:Palmitoylation is a reversible post-translational lipid modification that facilitates vesicular transport and subcellular localization of modified proteins. This process is catalyzed by ZDHHC enzymes that are implicated in several neurological and neurodevelopmental disorders. Loss-of-function mutations in ZDHHC9 have...

journal_title：Cell reports

authors： Shimell JJ,Shah BS,Cain SM,Thouta S,Kuhlmann N,Tatarnikov I,Jovellar DB,Brigidi GS,Kass J,Milnerwood AJ,Snutch TP,Bamji SX

更新日期：2019-11-19 00:00:00

abstract：:In mammals, a cell's decision to divide is thought to be under the control of the Rb/E2F pathway. We previously found that inactivation of the Rb family of cell cycle inhibitors (Rb, p107, and p130) in quiescent liver progenitors leads to uncontrolled division and cancer initiation. Here, we show that, in contrast, de...

journal_title：Cell reports

authors： Ehmer U,Zmoos AF,Auerbach RK,Vaka D,Butte AJ,Kay MA,Sage J

更新日期：2014-07-24 00:00:00

abstract：:We describe a mechanism by which the anti-apoptotic B cell lymphoma 2 (Bcl-2) protein is downregulated to induce apoptosis. ARTS (Sept4_i2) is a tumor suppressor protein that promotes cell death through specifically antagonizing XIAP (X-linked inhibitor of apoptosis). ARTS and Bcl-2 reside at the outer mitochondrial m...

journal_title：Cell reports

authors： Edison N,Curtz Y,Paland N,Mamriev D,Chorubczyk N,Haviv-Reingewertz T,Kfir N,Morgenstern D,Kupervaser M,Kagan J,Kim HT,Larisch S

更新日期：2017-10-10 00:00:00

abstract：:During chronic infection, the inflammatory cytokine interferon gamma (IFNγ) damages hematopoietic stem cells (HSCs) by disrupting quiescence and promoting excessive terminal differentiation. However, the mechanism by which IFNγ hinders HSC quiescence remains undefined. Using intravital 3-dimensional microscopy, we fin...

journal_title：Cell reports

authors： Florez MA,Matatall KA,Jeong Y,Ortinau L,Shafer PW,Lynch AM,Jaksik R,Kimmel M,Park D,King KY

更新日期：2020-12-22 00:00:00

abstract：:Plant glutamate receptor homologs (GLRs) have long been proposed to function as ligand-gated Ca2+ channels, but no in planta evidence has been provided. Here, we present genetic evidence that Arabidopsis GLR3.1 and GLR3.5 form Ca2+ channels activated by L-methionine (L-Met) at physiological concentrations and regulate...

journal_title：Cell reports

authors： Kong D,Hu HC,Okuma E,Lee Y,Lee HS,Munemasa S,Cho D,Ju C,Pedoeim L,Rodriguez B,Wang J,Im W,Murata Y,Pei ZM,Kwak JM

更新日期：2016-12-06 00:00:00

abstract：:Transcription factors often activate and repress different target genes in the same cell. How activation and repression are encoded by different arrangements of transcription factor binding sites in cis-regulatory elements is poorly understood. We investigated how sites for the transcription factor CRX encode both act...

journal_title：Cell reports

authors： White MA,Kwasnieski JC,Myers CA,Shen SQ,Corbo JC,Cohen BA

更新日期：2016-10-25 00:00:00

abstract：:Chromodomain Helicase DNA binding protein 5 (CHD5) is a tumor suppressor mapping to 1p36, a genomic region that is frequently deleted in human cancer. Although CHD5 belongs to the CHD family of chromatin-remodeling proteins, whether its tumor-suppressive role involves an interaction with chromatin is unknown. Here we ...

journal_title：Cell reports

authors： Paul S,Kuo A,Schalch T,Vogel H,Joshua-Tor L,McCombie WR,Gozani O,Hammell M,Mills AA

更新日期：2013-01-31 00:00:00

abstract：:Recently developed brain stimulation techniques have significantly advanced our ability to manipulate the brain's function. However, stimulating specific neurons in a desired region without significant surgical invasion remains a challenge. Here, we demonstrate a neuron-specific and region-targeted neural excitation s...

journal_title：Cell reports

authors： Qiu Z,Kala S,Guo J,Xian Q,Zhu J,Zhu T,Hou X,Wong KF,Yang M,Wang H,Sun L

更新日期：2020-08-18 00:00:00

abstract：:Neurodegenerative disorders are a major public health problem because of the high frequency of these diseases. Genome editing with the CRISPR/Cas9 system is making it possible to modify the sequence of genes linked to these disorders. We designed the KamiCas9 self-inactivating editing system to achieve transient expre...

journal_title：Cell reports

authors： Merienne N,Vachey G,de Longprez L,Meunier C,Zimmer V,Perriard G,Canales M,Mathias A,Herrgott L,Beltraminelli T,Maulet A,Dequesne T,Pythoud C,Rey M,Pellerin L,Brouillet E,Perrier AL,du Pasquier R,Déglon N

更新日期：2017-09-19 00:00:00

abstract：:To understand how the Bcl6 transcriptional repressor functions in the immune system, we disrupted its RD2 repression domain in mice. Bcl6RD2(MUT) mice exhibit a complete loss of germinal center (GC) formation but retain normal extrafollicular responses. Bcl6RD2(MUT) antigen-engaged B cells migrate to the interfollicul...

journal_title：Cell reports

authors： Huang C,Gonzalez DG,Cote CM,Jiang Y,Hatzi K,Teater M,Dai K,Hla T,Haberman AM,Melnick A

更新日期：2014-09-11 00:00:00

abstract：:Fibrillarin (FBL) is a dual-function nucleolar protein that catalyzes 2'-O methylation of pre-rRNA and methylation of histone H2A at glutamine 104 (H2AQ104me). The mechanisms that regulate FBL activity are unexplored. Here, we show that FBL is acetylated at several lysine residues by the acetyltransferase CBP and deac...

journal_title：Cell reports

authors： Iyer-Bierhoff A,Krogh N,Tessarz P,Ruppert T,Nielsen H,Grummt I

更新日期：2018-12-11 00:00:00

abstract：:The fossil record is widely informative about evolution, but fossils are not systematically used to study the evolution of stem-cell-driven renewal. Here, we examined evolution of the continuous growth (hypselodonty) of rodent molar teeth, which is fuelled by the presence of dental stem cells. We studied occurrences o...

journal_title：Cell reports

authors： Tapaltsyan V,Eronen JT,Lawing AM,Sharir A,Janis C,Jernvall J,Klein OD

更新日期：2015-05-05 00:00:00

abstract：:Genome editing has now been reported in many systems using TALEN and CRISPR-Cas9 nucleases. Precise mutations can be introduced during homology-directed repair with donor DNA carrying the wanted sequence edit, but efficiency is usually lower than for gene knockout and optimal strategies have not been extensively inves...

journal_title：Cell reports

authors： Renaud JB,Boix C,Charpentier M,De Cian A,Cochennec J,Duvernois-Berthet E,Perrouault L,Tesson L,Edouard J,Thinard R,Cherifi Y,Menoret S,Fontanière S,de Crozé N,Fraichard A,Sohm F,Anegon I,Concordet JP,Giovannangeli C

更新日期：2016-03-08 00:00:00

abstract：:Apolipoprotein M (apoM) is the carrier of sphingosine-1-phosphate (S1P) in plasma high-density lipoproteins. S1P is a bioactive lipid interacting with five receptors (S1P1-5). We show that lack of apoM in mice increases the amount of brown adipose tissue (BAT), accelerates the clearance of postprandial triglycerides, ...

journal_title：Cell reports

authors： Christoffersen C,Federspiel CK,Borup A,Christensen PM,Madsen AN,Heine M,Nielsen CH,Kjaer A,Holst B,Heeren J,Nielsen LB

更新日期：2018-01-02 00:00:00

abstract：:During development, neurons are constantly refining their connections in response to changes in activity. Experience-dependent plasticity is a key form of synaptic plasticity, involving changes in α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) accumulation at synapses. Here, we report a critical...

journal_title：Cell reports

authors： Louros SR,Hooks BM,Litvina L,Carvalho AL,Chen C

更新日期：2014-06-12 00:00:00

abstract：:FBXL2 targets IP3R3 for ubiquitin-mediated degradation to limit Ca2+ flux to mitochondria and, consequently, apoptosis. Efficient replication of hepatitis C virus (HCV) requires geranylgeranylation of FBXL2. Here, we show that the viral protein NS5A forms a trimeric complex with IP3R3 and FBXL2, unmasking IP3R3's degr...

journal_title：Cell reports

authors： Kuchay S,Saeed M,Giorgi C,Li J,Hoffmann HH,Pinton P,Rice CM,Pagano M

更新日期：2018-10-23 00:00:00

abstract：:We recently reported an autosomal dominant form of renal Fanconi syndrome caused by a missense mutation in the third codon of the peroxisomal protein EHHADH. The mutation mistargets EHHADH to mitochondria, thereby impairing mitochondrial energy production and, consequently, reabsorption of electrolytes and low-molecul...

journal_title：Cell reports

authors： Assmann N,Dettmer K,Simbuerger JMB,Broeker C,Nuernberger N,Renner K,Courtneidge H,Klootwijk ED,Duerkop A,Hall A,Kleta R,Oefner PJ,Reichold M,Reinders J

更新日期：2016-05-17 00:00:00

abstract：:Desensitization, signaling, and trafficking of G-protein-coupled receptors (GPCRs) are critically regulated by multifunctional adaptor proteins, β-arrestins (βarrs). The two isoforms of βarrs (βarr1 and 2) share a high degree of sequence and structural similarity; still, however, they often mediate distinct functional...

journal_title：Cell reports

authors： Ghosh E,Dwivedi H,Baidya M,Srivastava A,Kumari P,Stepniewski T,Kim HR,Lee MH,van Gastel J,Chaturvedi M,Roy D,Pandey S,Maharana J,Guixà-González R,Luttrell LM,Chung KY,Dutta S,Selent J,Shukla AK

更新日期：2019-09-24 00:00:00

abstract：:53BP1 plays multiple roles in mammalian DNA damage repair, mediating pathway choice and facilitating DNA double-strand break repair in heterochromatin. Although it possesses a C-terminal BRCT2 domain, commonly involved in phospho-peptide binding in other proteins, initial recruitment of 53BP1 to sites of DNA damage de...

journal_title：Cell reports

authors： Baldock RA,Day M,Wilkinson OJ,Cloney R,Jeggo PA,Oliver AW,Watts FZ,Pearl LH

更新日期：2015-12-15 00:00:00

abstract：:Either caspase-1 or caspase-11 can cleave gasdermin D to cause pyroptosis, eliminating intracellular replication niches. We previously showed that macrophages detect Burkholderia thailandensis via NLRC4, triggering the release of interleukin (IL)-18 and driving an essential interferon (IFN)-γ response that primes casp...

journal_title：Cell reports

authors： Kovacs SB,Oh C,Maltez VI,McGlaughon BD,Verma A,Miao EA,Aachoui Y

更新日期：2020-07-28 00:00:00