当前位置： SCI文献检索 > Cell Reports期刊下所有文献 > Poly(ADP-Ribose) Links the DNA Damage Response and Biomineralization.

Poly(ADP-Ribose) Links the DNA Damage Response and Biomineralization.

Abstract：

:Biomineralization of the extracellular matrix is an essential, regulated process. Inappropriate mineralization of bone and the vasculature has devastating effects on patient health, yet an integrated understanding of the chemical and cell biological processes that lead to mineral nucleation remains elusive. Here, we report that biomineralization of bone and the vasculature is associated with extracellular poly(ADP-ribose) synthesized by poly(ADP-ribose) polymerases in response to oxidative and/or DNA damage. We use ultrastructural methods to show poly(ADP-ribose) can form both calcified spherical particles, reminiscent of those found in vascular calcification, and biomimetically calcified collagen fibrils similar to bone. Importantly, inhibition of poly(ADP-ribose) biosynthesis in vitro and in vivo inhibits biomineralization, suggesting a therapeutic route for the treatment of vascular calcifications. We conclude that poly(ADP-ribose) plays a central chemical role in both pathological and physiological extracellular matrix calcification.

journal_name

Cell Rep

journal_title

Cell reports

authors

Müller KH,Hayward R,Rajan R,Whitehead M,Cobb AM,Ahmad S,Sun M,Goldberga I,Li R,Bashtanova U,Puszkarska AM,Reid DG,Brooks RA,Skepper JN,Bordoloi J,Chow WY,Oschkinat H,Groombridge A,Scherman OA,Harrison JA,Verhulst

doi

10.1016/j.celrep.2019.05.038

subject

Has Abstract

pub_date

2019-06-11 00:00:00

pages

3124-3138.e13

issue

11

issn

2211-1247

pii

S2211-1247(19)30658-8

journal_volume

27

pub_type

杂志文章

相关文献

Cell Reports文献大全
  • Posttranscriptional control of the stem cell and neurogenic programs by the nonsense-mediated RNA decay pathway.

    abstract：:The mechanisms dictating whether a cell proliferates or differentiates have undergone intense scrutiny, but they remain poorly understood. Here, we report that UPF1, a central component in the nonsense-mediated RNA decay (NMD) pathway, plays a key role in this decision by promoting the proliferative, undifferentiated ...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2014.01.028

    authors： Lou CH,Shao A,Shum EY,Espinoza JL,Huang L,Karam R,Wilkinson MF

    更新日期：2014-02-27 00:00:00

  • Hidden Structural Modules in a Cooperative RNA Folding Transition.

    abstract：:Large-scale, cooperative rearrangements underlie the functions of RNA in RNA-protein machines and gene regulation. To understand how such rearrangements are orchestrated, we used high-throughput chemical footprinting to dissect a seemingly concerted rearrangement in P5abc RNA, a paradigm of RNA folding studies. With m...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2018.02.101

    authors： Gracia B,Al-Hashimi HM,Bisaria N,Das R,Herschlag D,Russell R

    更新日期：2018-03-20 00:00:00

  • Cell-to-Cell Heterogeneity in p38-Mediated Cross-Inhibition of JNK Causes Stochastic Cell Death.

    abstract：:The stress-activated protein kinases c-Jun N-terminal kinase (JNK) and p38 are important players in cell-fate decisions in response to environmental stress signals. Crosstalk signaling between JNK and p38 is emerging as an important regulatory mechanism in inflammatory and stress responses. However, it is unknown how ...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2018.08.020

    authors： Miura H,Kondo Y,Matsuda M,Aoki K

    更新日期：2018-09-04 00:00:00

  • T-Bet+ IgM Memory Cells Generate Multi-lineage Effector B Cells.

    abstract：:Immunoglobulin M (IgM) memory cells undergo differentiation in germinal centers following antigen challenge, but the full effector cell potential of these cells is unknown. We monitored the differentiation of enhanced yellow fluorescent protein (eYFP)-labeled CD11c+ and CD11cneg T-bet+ IgM memory cells after their tra...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2018.06.074

    authors： Kenderes KJ,Levack RC,Papillion AM,Cabrera-Martinez B,Dishaw LM,Winslow GM

    更新日期：2018-07-24 00:00:00

  • Agrin as a Mechanotransduction Signal Regulating YAP through the Hippo Pathway.

    abstract：:The Hippo pathway effectors YAP and TAZ act as nuclear sensors of mechanical signals in response to extracellular matrix (ECM) cues. However, the identity and nature of regulators in the ECM and the precise pathways relaying mechanoresponsive signals into intracellular sensors remain unclear. Here, we uncover a functi...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2017.02.041

    authors： Chakraborty S,Njah K,Pobbati AV,Lim YB,Raju A,Lakshmanan M,Tergaonkar V,Lim CT,Hong W

    更新日期：2017-03-07 00:00:00

  • Regulation of Autocrine Signaling in Subsets of Sympathetic Neurons Has Regional Effects on Tissue Innervation.

    abstract：:The regulation of innervation by target-derived factors like nerve growth factor (NGF) is the cornerstone of neurotrophic theory. Whereas autocrine signaling in neurons affecting survival and axon growth has been described, it is difficult to reconcile autocrine signaling with the idea that targets control their inner...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2015.02.016

    authors： McWilliams TG,Howard L,Wyatt S,Davies AM

    更新日期：2015-03-10 00:00:00

  • S1PR1 is crucial for accumulation of regulatory T cells in tumors via STAT3.

    abstract：:S1PR1 signaling has been shown to restrain the number and function of regulatory T (Treg) cells in the periphery under physiological conditions and in colitis models, but its role in regulating tumor-associated T cells is unknown. Here, we show that S1PR1 signaling in T cells drives Treg accumulation in tumors, limits...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2014.02.016

    authors： Priceman SJ,Shen S,Wang L,Deng J,Yue C,Kujawski M,Yu H

    更新日期：2014-03-27 00:00:00

  • Regulation of Stat5 by FAK and PAK1 in Oncogenic FLT3- and KIT-Driven Leukemogenesis.

    abstract：:Oncogenic mutations of FLT3 and KIT receptors are associated with poor survival in patients with acute myeloid leukemia (AML) and myeloproliferative neoplasms (MPNs), and currently available drugs are largely ineffective. Although Stat5 has been implicated in regulating several myeloid and lymphoid malignancies, how p...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2014.10.039

    authors： Chatterjee A,Ghosh J,Ramdas B,Mali RS,Martin H,Kobayashi M,Vemula S,Canela VH,Waskow ER,Visconte V,Tiu RV,Smith CC,Shah N,Bunting KD,Boswell HS,Liu Y,Chan RJ,Kapur R

    更新日期：2014-11-20 00:00:00

  • Sequence and Nuclease Requirements for Breakage and Healing of a Structure-Forming (AT)n Sequence within Fragile Site FRA16D.

    abstract：:Common fragile sites (CFSs) are genomic regions that display gaps and breaks in human metaphase chromosomes under replication stress and are often deleted in cancer cells. We studied an ∼300-bp subregion (Flex1) of human CFS FRA16D in yeast and found that it recapitulates characteristics of CFS fragility in human cell...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2019.03.103

    authors： Kaushal S,Wollmuth CE,Das K,Hile SE,Regan SB,Barnes RP,Haouzi A,Lee SM,House NCM,Guyumdzhyan M,Eckert KA,Freudenreich CH

    更新日期：2019-04-23 00:00:00

  • FAD Regulates CRYPTOCHROME Protein Stability and Circadian Clock in Mice.

    abstract：:The circadian clock generates biological rhythms of metabolic and physiological processes, including the sleep-wake cycle. We previously identified a missense mutation in the flavin adenine dinucleotide (FAD) binding pocket of CRYPTOCHROME2 (CRY2), a clock protein that causes human advanced sleep phase. This prompted ...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2017.03.041

    authors： Hirano A,Braas D,Fu YH,Ptáček LJ

    更新日期：2017-04-11 00:00:00

  • DET1 and HY5 Control PIF4-Mediated Thermosensory Elongation Growth through Distinct Mechanisms.

    abstract：:Plant growth and development are defined by environmental cues. The transcription factor PHYTOCHROME INTERACTING FACTOR 4 (PIF4) is the central signaling hub that integrates environmental cues, including light and temperature, to regulate growth and development. The thermosensory mechanisms controlling the PIF4-mediat...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2016.12.046

    authors： Gangappa SN,Kumar SV

    更新日期：2017-01-10 00:00:00

  • Measurement of Rapid Protein Diffusion in the Cytoplasm by Photo-Converted Intensity Profile Expansion.

    abstract：:The fluorescence microscopy methods presently used to characterize protein motion in cells infer protein motion from indirect observables, rather than measuring protein motion directly. Operationalizing these methods requires expertise that can constitute a barrier to their broad utilization. Here, we have developed P...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2017.02.063

    authors： Gura Sadovsky R,Brielle S,Kaganovich D,England JL

    更新日期：2017-03-14 00:00:00

  • Sequence and Structural Analyses Reveal Distinct and Highly Diverse Human CD8+ TCR Repertoires to Immunodominant Viral Antigens.

    abstract：:A diverse T cell receptor (TCR) repertoire is essential for controlling viral infections. However, information about TCR repertoires to defined viral antigens is limited. We performed a comprehensive analysis of CD8+ TCR repertoires for two dominant viral epitopes: pp65495-503 (NLV) of cytomegalovirus and M158-66 (GIL...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2017.03.072

    authors： Chen G,Yang X,Ko A,Sun X,Gao M,Zhang Y,Shi A,Mariuzza RA,Weng NP

    更新日期：2017-04-18 00:00:00

  • Opposing effect of EGFRWT on EGFRvIII-mediated NF-κB activation with RIP1 as a cell death switch.

    abstract：:RIP1 is a central mediator of cell death in response to cell stress but can also mediate cell survival by activating NF-κB. Here, we show that RIP1 acts as a switch in EGFR signaling. EGFRvIII is an oncogenic mutant that does not bind ligand and is coexpressed with EGFRWT in glioblastoma multiforme (GBM). EGFRvIII rec...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2013.07.025

    authors： Puliyappadamba VT,Chakraborty S,Chauncey SS,Li L,Hatanpaa KJ,Mickey B,Noorani S,Shu HK,Burma S,Boothman DA,Habib AA

    更新日期：2013-08-29 00:00:00

  • TGF-β Signaling Is Necessary and Sufficient for Pharyngeal Arch Artery Angioblast Formation.

    abstract：:The pharyngeal arch arteries (PAAs) are transient embryonic blood vessels that mature into critical segments of the aortic arch and its branches. Although defects in PAA development cause life-threating congenital cardiovascular defects, the molecular mechanisms that orchestrate PAA morphogenesis remain unclear. Throu...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2017.07.002

    authors： Abrial M,Paffett-Lugassy N,Jeffrey S,Jordan D,O'Loughlin E,Frederick CJ 3rd,Burns CG,Burns CE

    更新日期：2017-07-25 00:00:00

  • Esrp1-Regulated Splicing of Arhgef11 Isoforms Is Required for Epithelial Tight Junction Integrity.

    abstract：:The epithelial-specific splicing regulators Esrp1 and Esrp2 are required for mammalian development, including establishment of epidermal barrier functions. However, the mechanisms by which Esrp ablation causes defects in epithelial barriers remain undefined. We determined that the ablation of Esrp1 and Esrp2 impairs e...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2018.10.097

    authors： Lee S,Cieply B,Yang Y,Peart N,Glaser C,Chan P,Carstens RP

    更新日期：2018-11-27 00:00:00

  • Single-Cell Gene Expression Analyses Reveal Heterogeneous Responsiveness of Fetal Innate Lymphoid Progenitors to Notch Signaling.

    abstract：:T and innate lymphoid cells (ILCs) share some aspects of their developmental programs. However, although Notch signaling is strictly required for T cell development, it is dispensable for fetal ILC development. Constitutive activation of Notch signaling, at the common lymphoid progenitor stage, drives T cell developme...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2016.01.015

    authors： Chea S,Schmutz S,Berthault C,Perchet T,Petit M,Burlen-Defranoux O,Goldrath AW,Rodewald HR,Cumano A,Golub R

    更新日期：2016-02-16 00:00:00

  • Muscarinic Acetylcholine Receptors Chrm1 and Chrm3 Are Essential for REM Sleep.

    abstract：:Sleep regulation involves interdependent signaling among specialized neurons in distributed brain regions. Although acetylcholine promotes wakefulness and rapid eye movement (REM) sleep, it is unclear whether the cholinergic pathway is essential (i.e., absolutely required) for REM sleep because of redundancy from neur...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2018.07.082

    authors： Niwa Y,Kanda GN,Yamada RG,Shi S,Sunagawa GA,Ukai-Tadenuma M,Fujishima H,Matsumoto N,Masumoto KH,Nagano M,Kasukawa T,Galloway J,Perrin D,Shigeyoshi Y,Ukai H,Kiyonari H,Sumiyama K,Ueda HR

    更新日期：2018-08-28 00:00:00

  • Downmodulation of CCR7 by HIV-1 Vpu results in impaired migration and chemotactic signaling within CD4⁺ T cells.

    abstract：:The chemokine receptor CCR7 plays a crucial role in the homing of central memory and naive T cells to peripheral lymphoid organs. Here, we show that the HIV-1 accessory protein Vpu downregulates CCR7 on the surface of CD4(+) T cells. Vpu and CCR7 were found to specifically interact and colocalize within the trans-Golg...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2014.05.015

    authors： Ramirez PW,Famiglietti M,Sowrirajan B,DePaula-Silva AB,Rodesch C,Barker E,Bosque A,Planelles V

    更新日期：2014-06-26 00:00:00

  • Sox2 cooperates with Lkb1 loss in a mouse model of squamous cell lung cancer.

    abstract：:Squamous cell carcinoma (SCC) of the lung is the second most common subtype of lung cancer. With limited treatment options, the 5-year survival rate of SCC is only 15%. Although genomic alterations in SCC have been characterized, identifying the alterations that drive SCC is critical for improving treatment strategies...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2014.05.036

    authors： Mukhopadhyay A,Berrett KC,Kc U,Clair PM,Pop SM,Carr SR,Witt BL,Oliver TG

    更新日期：2014-07-10 00:00:00

  • HJURP involvement in de novo CenH3(CENP-A) and CENP-C recruitment.

    abstract：:Although our understanding of centromere maintenance, marked by the histone H3 variant CenH3(CENP-A) in most eukaryotes, has progressed, the mechanism underlying the de novo formation of centromeres remains unclear. We used a synthetic system to dissect how CenH3(CENP-A) contributes to the accumulation of CENP-C and C...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2015.03.013

    authors： Tachiwana H,Müller S,Blümer J,Klare K,Musacchio A,Almouzni G

    更新日期：2015-04-07 00:00:00

  • Single-Cell RNA Profiling Reveals Adipocyte to Macrophage Signaling Sufficient to Enhance Thermogenesis.

    abstract：:Adipocytes deficient in fatty acid synthase (iAdFASNKO) emit signals that mimic cold exposure to enhance the appearance of thermogenic beige adipocytes in mouse inguinal white adipose tissues (iWATs). Both cold exposure and iAdFASNKO upregulate the sympathetic nerve fiber (SNF) modulator Neuregulin 4 (Nrg4), activate ...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2020.107998

    authors： Henriques F,Bedard AH,Guilherme A,Kelly M,Chi J,Zhang P,Lifshitz LM,Bellvé K,Rowland LA,Yenilmez B,Kumar S,Wang Y,Luban J,Weinstein LS,Lin JD,Cohen P,Czech MP

    更新日期：2020-08-04 00:00:00

  • Overexpression of Trophoblast Stem Cell-Enriched MicroRNAs Promotes Trophoblast Fate in Embryonic Stem Cells.

    abstract：:The first cell fate choice of the preimplantation embryo generates the extraembryonic trophoblast and embryonic epiblast lineages. Embryonic stem cells (ESCs) and trophoblast stem cells (TSCs) can be utilized to investigate molecular mechanisms of this first cell fate decision. It has been established that ESCs can be...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2017.04.040

    authors： Nosi U,Lanner F,Huang T,Cox B

    更新日期：2017-05-09 00:00:00

  • HIV-1-Infected CD4+ T Cells Facilitate Latent Infection of Resting CD4+ T Cells through Cell-Cell Contact.

    abstract：:HIV-1 is transmitted between T cells through the release of cell-free particles and through cell-cell contact. Cell-to-cell transmission is more efficient than cell-free virus transmission, mediates resistance to immune responses, and facilitates the spread of virus among T cells. However, whether HIV cell-to-cell tra...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2018.07.079

    authors： Agosto LM,Herring MB,Mothes W,Henderson AJ

    更新日期：2018-08-21 00:00:00

  • Synaptogenesis Stimulates a Proteasome-Mediated Ribosome Reduction in Axons.

    abstract：:Ribosomes and a subset of cellular mRNAs are trafficked into axons of developing neurons. The axonal localization of translational machinery allows new proteins to be rapidly and locally synthesized during axonal growth and pathfinding. However, in mature neurons, axonal ribosomes are significantly reduced or even abs...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2019.06.080

    authors： Costa RO,Martins H,Martins LF,Cwetsch AW,Mele M,Pedro JR,Tomé D,Jeon NL,Cancedda L,Jaffrey SR,Almeida RD

    更新日期：2019-07-23 00:00:00

  • Elucidating sources and roles of granzymes A and B during bacterial infection and sepsis.

    abstract：:During bacterial sepsis, proinflammatory cytokines contribute to multiorgan failure and death in a process regulated in part by cytolytic cell granzymes. When challenged with a sublethal dose of the identified mouse pathogen Brucella microti, wild-type (WT) and granzyme A (gzmA)(-/-) mice eliminate the organism from l...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2014.06.012

    authors： Arias MA,Jiménez de Bagües MP,Aguiló N,Menao S,Hervás-Stubbs S,de Martino A,Alcaraz A,Simon MM,Froelich CJ,Pardo J

    更新日期：2014-07-24 00:00:00

  • Autoreactive IgG and IgA B Cells Evolve through Distinct Subclass Switch Pathways in the Autoimmune Disease Pemphigus Vulgaris.

    abstract：:Lineage analysis of autoreactive B cells can reveal the origins of autoimmunity. In the autoimmune disease pemphigus vulgaris (PV), desmoglein 3 (DSG3) and DSG1 autoantibodies are predominantly of the IgG4 subclass and less frequently of IgG1 and IgA subclasses, prompting us to investigate whether anti-DSG IgG4 B cell...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2018.07.093

    authors： Ellebrecht CT,Mukherjee EM,Zheng Q,Choi EJ,Reddy SG,Mao X,Payne AS

    更新日期：2018-08-28 00:00:00

  • Adaptive Evolution of MERS-CoV to Species Variation in DPP4.

    abstract：:Middle East Respiratory Syndrome Coronavirus (MERS-CoV) likely originated in bats and passed to humans through dromedary camels; however, the genetic mechanisms underlying cross-species adaptation remain poorly understood. Variation in the host receptor, dipeptidyl peptidase 4 (DPP4), can block the interaction with th...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2018.07.045

    authors： Letko M,Miazgowicz K,McMinn R,Seifert SN,Sola I,Enjuanes L,Carmody A,van Doremalen N,Munster V

    更新日期：2018-08-14 00:00:00

  • Roles of H3K27me2 and H3K27me3 Examined during Fate Specification of Embryonic Stem Cells.

    abstract：:The polycomb repressive complex 2 (PRC2) methylates lysine 27 of histone H3 (H3K27) through its catalytic subunit Ezh2. PRC2-mediated di- and tri-methylation (H3K27me2/H3K27me3) have been interchangeably associated with gene repression. However, it remains unclear whether these two degrees of H3K27 methylation have di...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2016.09.087

    authors： Juan AH,Wang S,Ko KD,Zare H,Tsai PF,Feng X,Vivanco KO,Ascoli AM,Gutierrez-Cruz G,Krebs J,Sidoli S,Knight AL,Pedersen RA,Garcia BA,Casellas R,Zou J,Sartorelli V

    更新日期：2016-10-25 00:00:00

  • Molecular identification of t(w5): Vps52 promotes pluripotential cell differentiation through cell-cell interactions.

    abstract：:After implantation, pluripotent epiblasts are converted to embryonic ectoderm through cell-cell interactions that significantly change the transcriptional and epigenetic networks. An entrée to understanding this vital developmental transition is the t(w5) mutation of the mouse t complex. This mutation produces highly ...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2012.10.004

    authors： Sugimoto M,Kondo M,Hirose M,Suzuki M,Mekada K,Abe T,Kiyonari H,Ogura A,Takagi N,Artzt K,Abe K

    更新日期：2012-11-29 00:00:00