Abstract：
:In higher vertebrates, cephalic neural crest cells (NCCs) form craniofacial skeleton by differentiating into chondrocytes and osteoblasts. A subpopulation of cephalic NCCs, cardiac NCCs (CNCCs), migrates to the heart. However, CNCCs mostly do not yield skeletogenic derivatives, and the molecular mechanisms of this fate restriction remain elusive. We identify a disintegrin and metalloprotease 19 (Adam19) as a position-specific fate regulator of NCCs. Adam19-depleted mice abnormally form NCC-derived cartilage in their hearts through the upregulation of Sox9 levels in CNCCs. Moreover, NCC-lineage-specific Sox9-overexpressing mice recapitulate CNCC chondrogenesis. In vitro experiments show that Adam19 mediates the cleavage of bone morphogenic protein (BMP) type I receptor Alk2 (Acvr1), whereas pharmacogenetic approaches reveal that Adam19 inhibits CNCC chondrogenesis by suppressing the BMP-Sox9 cascade, presumably through processing Alk2. These findings suggest a metalloprotease-dependent mechanism attenuating cellular responsiveness to BMP ligands, which is essential for both the positional restriction of NCC skeletogenesis and normal heart development.
journal_name
Cell Repjournal_title
Cell reportsauthors
Arai HN,Sato F,Yamamoto T,Woltjen K,Kiyonari H,Yoshimoto Y,Shukunami C,Akiyama H,Kist R,Sehara-Fujisawa Adoi
10.1016/j.celrep.2019.09.019subject
Has Abstractpub_date
2019-10-15 00:00:00pages
603-616.e5issue
3issn
2211-1247pii
S2211-1247(19)31196-9journal_volume
29pub_type
杂志文章相关文献
Cell Reports文献大全abstract：:Transcription of developmental genes is controlled by multiple enhancers. Frequently, more than one enhancer can activate transcription from the same promoter in the same cells. How is regulatory information from multiple enhancers combined to determine the overall expression output? We measure nascent transcription d...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2019.01.115
更新日期：2019-02-26 00:00:00
abstract：:Neural modulation in primate motor cortex exhibits complex patterns. We found that modulation during reaching could be separated into discrete temporal epochs. To determine if these epochs are driven by behavioral events, monkeys performed variations of a center-out reaching task. Monkeys viewed a computer cursor matc...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2019.11.069
更新日期：2019-12-17 00:00:00
abstract：:Hypoxia-inducible factors (HIFs) are critical regulators of the cellular response to hypoxia. Despite their established roles in normal physiology and numerous pathologies, the molecular mechanisms by which they control gene expression remain poorly understood. We report here a conserved role for the TIP60 complex as ...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2016.05.082
更新日期：2016-06-28 00:00:00
abstract：:Lysine-Specific Demethylase 1 (LSD1, KDM1A) functions as a transcriptional corepressor through demethylation of histone 3 lysine 4 (H3K4) but has a coactivator function on some genes through mechanisms that are unclear. We show that LSD1, interacting with CoREST, associates with and coactivates androgen receptor (AR) ...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2014.11.008
更新日期：2014-12-11 00:00:00
abstract：:Coordinate control of T cell proliferation, survival, and differentiation are essential for host protection from pathogens and cancer. Long-lived memory cells, whose precursors are formed during the initial immunological insult, provide protection from future encounters, and their generation is the goal of many vaccin...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2019.07.064
更新日期：2019-08-20 00:00:00
abstract：:Brain plasticity is often restricted to critical periods in early life. Here, we show that a key regulator of this process in the visual cortex, Otx2 homeoprotein, is synthesized and secreted globally from the choroid plexus. Consequently, Otx2 is maintained in selected GABA cells unexpectedly throughout the mature fo...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2013.05.014
更新日期：2013-06-27 00:00:00
abstract：:Zinc-finger E-box binding homeobox 1 (Zeb1) is a key regulator of epithelial-mesenchymal transition and cancer metastasis. Mutation of ZEB1 is associated with human diseases and defective brain development. Here we show that downregulation of Zeb1 expression in embryonic cortical neural progenitor cells (NPCs) is nece...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2019.04.081
更新日期：2019-05-21 00:00:00
abstract：:CRISPR genome engineering has become a powerful tool to functionally investigate the complex mechanisms of immune system regulation. While decades of work have aimed to genetically reprogram innate immunity, the utility of current approaches is restricted by poor knockout efficiencies or limited specificity for mature...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2020.107651
更新日期：2020-05-19 00:00:00
abstract：:Heterobifunctional proteolysis-targeting chimeric compounds leverage the activity of E3 ligases to induce degradation of target oncoproteins and exhibit potent preclinical antitumor activity. To dissect the mechanisms regulating tumor cell sensitivity to different classes of pharmacological "degraders" of oncoproteins...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2020.108532
更新日期：2021-01-05 00:00:00
abstract：:Pneumonias caused by influenza A virus (IAV) co- and secondary bacterial infections are characterized by their severity and high mortality rate. Previously, we have shown that bacterial pore-forming toxin (PFT)-mediated necroptosis is a key driver of acute lung injury during bacterial pneumonia. Here, we evaluate the ...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2020.108062
更新日期：2020-08-25 00:00:00
abstract：:Glucagon-like peptide-1 receptor (GLP-1R) agonists used to treat type 2 diabetes mellitus often produce nausea, vomiting, and in some patients, undesired anorexia. Notably, these behavioral effects are caused by direct central GLP-1R activation. Herein, we describe the creation of a GLP-1R agonist conjugate with modif...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2020.107768
更新日期：2020-06-16 00:00:00
abstract：:Synaptic efficacy plays crucial roles in neuronal circuit operation and synaptic plasticity. Presynaptic determinants of synaptic efficacy are neurotransmitter content in synaptic vesicles and the number of vesicles undergoing exocytosis at a time. Bursts of presynaptic firings depress synaptic efficacy, mainly due to...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2018.02.080
更新日期：2018-03-20 00:00:00
abstract：:T follicular helper (Tfh) cells are crucial for the establishment of germinal centers (GCs) and potent antibody responses. Nevertheless, the T cell-intrinsic factors that are required for the maintenance of already-established Tfh cells and GCs remain largely unknown. Here, we use temporally guided gene ablation in CD...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2020.108232
更新日期：2020-10-06 00:00:00
abstract：:Development and function of pancreatic β cells involve the regulated activity of specific transcription factors. RFX6 is a transcription factor essential for mouse β cell differentiation that is mutated in monogenic forms of neonatal diabetes. However, the expression and functional roles of RFX6 in human β cells, espe...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2014.11.010
更新日期：2014-12-24 00:00:00
abstract：:Cytokinesis, the final step of cell division, begins with the formation of a cleavage furrow. How the mitotic spindle specifies the furrow at the equator in animal cells remains unknown. Current models propose that the concentration of the RhoGEF ECT2 at the spindle midzone and the equatorial plasma membrane directs f...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2016.11.029
更新日期：2016-12-06 00:00:00
abstract：:Accumulation of toxic amyloid oligomers is a key feature in the pathogenesis of amyloid-related diseases. Formation of mature amyloid fibrils is one defense mechanism to neutralize toxic prefibrillar oligomers. This mechanism is notably influenced by apolipoprotein E variants. Cells that produce mature amyloid fibrils...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2015.08.057
更新日期：2015-10-06 00:00:00
abstract：:Colorectal cancer (CRC) initiation and growth is often attributed to stem cells, yet little is known about the regulation of these cells. We show here that a subpopulation of Prox1-transcription-factor-expressing cells have stem cell activity in intestinal adenomas, but not in the normal intestine. Using in vivo model...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2014.08.034
更新日期：2014-09-25 00:00:00
abstract：:The transcription factors (TFs) Nanog and Esrrb play important roles in embryonic stem cells (ESCs) and during primordial germ-cell (PGC) development. Esrrb is a positively regulated direct target of NANOG in ESCs that can substitute qualitatively for Nanog function in ESCs. Whether this functional substitution extend...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2017.12.060
更新日期：2018-01-09 00:00:00
abstract：:The number of essential telomerase components in the active ribonucleoprotein (RNP) has important implications for its mechanism of action yet is by and large unknown. We report that two differentially tagged TLC1 RNAs endogenously expressed in a heterozygous diploid and simultaneously detected via multi-color fluores...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2015.06.045
更新日期：2015-07-21 00:00:00
abstract：:We have previously found that UV irradiation promotes RNA polymerase II (RNAPII) hyperphosphorylation and subsequent changes in alternative splicing (AS). We show now that UV-induced DNA damage is not only necessary but sufficient to trigger the AS response and that photolyase-mediated removal of the most abundant cla...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2017.02.066
更新日期：2017-03-21 00:00:00
abstract：:Information gained during goal pursuit motivates adaptive behavior. The anterior cingulate cortex (ACC) supports adaptive behavior, but how ACC signals are translated into motivational signals remains unclear. Rats with implants in the ACC and ventral tegmental area (VTA), a dopaminergic brain area implicated in motiv...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2017.05.062
更新日期：2017-06-13 00:00:00
abstract：:The cellular responses induced by mitochondrial dysfunction remain elusive. Intrigued by the lack of almost any glomerular phenotype in patients with profound renal ischemia, we comprehensively investigated the primary sources of energy of glomerular podocytes. Combining functional measurements of oxygen consumption r...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2019.04.012
更新日期：2019-04-30 00:00:00
abstract：:Mural cells (pericytes and vascular smooth muscle cells) are essential for the regulation of vascular networks and maintenance of vascular integrity, but their origins are diverse in different tissues and not known in the organs that arise from the ectoderm, such as skin. Here, we show that tissue-localized myeloid pr...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2017.02.069
更新日期：2017-03-21 00:00:00
abstract：:Learning critically depends on the ability to rapidly form and store non-overlapping representations of the external world. In line with their postulated role in episodic memory, hippocampal place cells can undergo a rapid reorganization of their firing fields upon contextual manipulations. To explore the mechanisms u...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2018.03.031
更新日期：2018-04-03 00:00:00
abstract：:Developing strategies that promote the resolution of vascular inflammation and atherosclerosis remains a major therapeutic challenge. Here, we show that exosomes produced by naive bone marrow-derived macrophages (BMDM-exo) contain anti-inflammatory microRNA-99a/146b/378a that are further increased in exosomes produced...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2020.107881
更新日期：2020-07-14 00:00:00
abstract：:Although bacterial cell morphology is tightly controlled, the principles of size regulation remain elusive. In Escherichia coli, perturbation of cell-wall synthesis often results in similar morphologies, making it difficult to deconvolve the complex genotype-phenotype relationships underlying morphogenesis. Here we mo...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2014.10.027
更新日期：2014-11-20 00:00:00
abstract：:Even though hyperthermia is a promising treatment for cancer, the relationship between specific temperatures and clinical benefits and predictors of sensitivity of cancer to hyperthermia is poorly understood. Ovarian and uterine tumors have diverse hyperthermia sensitivities. Integrative analyses of the specific gene ...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2016.10.020
更新日期：2016-11-01 00:00:00
abstract：:The Zika virus (ZIKV) poses a major public health emergency. To aid in the development of antivirals, we present two high-resolution crystal structures of the ZIKV NS5 methyltransferase: one bound to S-adenosylmethionine (SAM) and the other bound to SAM and 7-methyl guanosine diphosphate (7-MeGpp). We identify feature...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2016.08.091
更新日期：2016-09-20 00:00:00
abstract：:G9a is a lysine methyltransferase that regulates epigenetic modifications, transcription, and genome organization. However, whether these properties are dependent on one another or represent distinct functions of G9a remains unclear. In this study, we observe widespread DNA methylation loss in G9a depleted and catalyt...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2020.108315
更新日期：2020-10-27 00:00:00
abstract：:Neurons face unique transport challenges. They need to deliver cargo over long axonal distances and to many presynaptic nerve terminals. Rab GTPases are master regulators of vesicular traffic, but essential presynaptic Rabs have not been identified. Here, we find that Rab6, a Golgi-derived GTPase for constitutive secr...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2020.107712
更新日期：2020-06-09 00:00:00
