Abstract：
:Nono is a component of the para-speckle, which stores and processes RNA. Mouse embryonic stem cells (mESCs) lack para-speckles, leaving the function of Nono in mESCs unclear. Here, we find that Nono functions as a chromatin regulator cooperating with Erk to regulate mESC pluripotency. We report that Nono loss results in robust self-renewing mESCs with epigenomic and transcriptomic features resembling the 2i (GSK and Erk inhibitors)-induced "ground state." Erk interacts with and is required for Nono localization to a subset of bivalent genes that have high levels of poised RNA polymerase. Nono loss compromises Erk activation and RNA polymerase poising at its target bivalent genes in undifferentiated mESCs, thus disrupting target gene activation and differentiation. These findings argue that Nono collaborates with Erk signaling to regulate the integrity of bivalent domains and mESC pluripotency.
journal_name
Cell Repjournal_title
Cell reportsauthors
Ma C,Karwacki-Neisius V,Tang H,Li W,Shi Z,Hu H,Xu W,Wang Z,Kong L,Lv R,Fan Z,Zhou W,Yang P,Wu F,Diao J,Tan L,Shi YG,Lan F,Shi Ydoi
10.1016/j.celrep.2016.09.078subject
Has Abstractpub_date
2016-10-18 00:00:00pages
997-1007issue
4issn
2211-1247pii
S2211-1247(16)31334-1journal_volume
17pub_type
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