Abstract：
:Spontaneous neurotransmitter release is a core element of synaptic communication in mature neurons, but despite exceptionally high levels of spontaneous vesicle cycling occurring in developing axons, little is known of its function during this period. We now show that high-level, spontaneous axonal release of the neurotransmitter glutamate can signal at long range to NMDA receptors on developing dendrites, prior to synapse formation and, indeed, axodendritic contact. Blockade of NMDA signaling during this early period of spontaneous vesicle cycling leads to a reduction in dendritic arbor complexity, indicating an important role for early spontaneous release in dendritic arbor growth.
journal_name
Cell Repjournal_title
Cell reportsauthors
Andreae LC,Burrone Jdoi
10.1016/j.celrep.2015.01.032subject
Has Abstractpub_date
2015-02-17 00:00:00pages
873-882issue
6issn
2211-1247pii
S2211-1247(15)00057-1journal_volume
10pub_type
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