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Transcription factor networks in Drosophila melanogaster.

Abstract：

:Specific cellular fates and functions depend on differential gene expression, which occurs primarily at the transcriptional level and is controlled by complex regulatory networks of transcription factors (TFs). TFs act through combinatorial interactions with other TFs, cofactors, and chromatin-remodeling proteins. Here, we define protein-protein interactions using a coaffinity purification/mass spectrometry method and study 459 Drosophila melanogaster transcription-related factors, representing approximately half of the established catalog of TFs. We probe this network in vivo, demonstrating functional interactions for many interacting proteins, and test the predictive value of our data set. Building on these analyses, we combine regulatory network inference models with physical interactions to define an integrated network that connects combinatorial TF protein interactions to the transcriptional regulatory network of the cell. We use this integrated network as a tool to connect the functional network of genetic modifiers related to mastermind, a transcriptional cofactor of the Notch pathway.

journal_name

Cell Rep

journal_title

Cell reports

authors

Rhee DY,Cho DY,Zhai B,Slattery M,Ma L,Mintseris J,Wong CY,White KP,Celniker SE,Przytycka TM,Gygi SP,Obar RA,Artavanis-Tsakonas S

doi

10.1016/j.celrep.2014.08.038

subject

Has Abstract

pub_date

2014-09-25 00:00:00

pages

2031-2043

issue

6

issn

2211-1247

pii

S2211-1247(14)00714-1

journal_volume

8

pub_type

杂志文章

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