Abstract：
:Pneumonias caused by influenza A virus (IAV) co- and secondary bacterial infections are characterized by their severity and high mortality rate. Previously, we have shown that bacterial pore-forming toxin (PFT)-mediated necroptosis is a key driver of acute lung injury during bacterial pneumonia. Here, we evaluate the impact of IAV on PFT-induced acute lung injury during co- and secondary Streptococcus pneumoniae (Spn) infection. We observe that IAV synergistically sensitizes lung epithelial cells for PFT-mediated necroptosis in vitro and in murine models of Spn co-infection and secondary infection. Pharmacoelogical induction of oxidative stress without virus sensitizes cells for PFT-mediated necroptosis. Antioxidant treatment or inhibition of necroptosis reduces disease severity during secondary bacterial infection. Our results advance our understanding on the molecular basis of co- and secondary bacterial infection to influenza and identify necroptosis inhibition and antioxidant therapy as potential intervention strategies.
journal_name
Cell Repjournal_title
Cell reportsauthors
Gonzalez-Juarbe N,Riegler AN,Jureka AS,Gilley RP,Brand JD,Trombley JE,Scott NR,Platt MP,Dube PH,Petit CM,Harrod KS,Orihuela CJdoi
10.1016/j.celrep.2020.108062subject
Has Abstractpub_date
2020-08-25 00:00:00pages
108062issue
8issn
2211-1247pii
S2211-1247(20)31047-0journal_volume
32pub_type
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