Deletion of human tarbp2 reveals cellular microRNA targets and cell-cycle function of TRBP.

abstract：:Tissue-resident memory T (TRM) cells provide key adaptive immune responses in infection, cancer, and autoimmunity. However, transcriptional heterogeneity of human intestinal TRM cells remains undefined. Here, we investigate transcriptional and functional heterogeneity of human TRM cells through study of donor-derived ...

journal_title：Cell reports

authors： FitzPatrick MEB,Provine NM,Garner LC,Powell K,Amini A,Irwin SL,Ferry H,Ambrose T,Friend P,Vrakas G,Reddy S,Soilleux E,Klenerman P,Allan PJ

更新日期：2021-01-19 00:00:00

abstract：:In mammals, a cell's decision to divide is thought to be under the control of the Rb/E2F pathway. We previously found that inactivation of the Rb family of cell cycle inhibitors (Rb, p107, and p130) in quiescent liver progenitors leads to uncontrolled division and cancer initiation. Here, we show that, in contrast, de...

journal_title：Cell reports

authors： Ehmer U,Zmoos AF,Auerbach RK,Vaka D,Butte AJ,Kay MA,Sage J

更新日期：2014-07-24 00:00:00

abstract：:Hypertrophic white adipose tissue (WAT) represents a maladaptive mechanism linked to the risk for developing type 2 diabetes in humans. However, the molecular events that predispose WAT to hypertrophy are poorly defined. Here, we demonstrate that adipocyte hypertrophy is triggered by loss of the corepressor GPS2 durin...

journal_title：Cell reports

authors： Drareni K,Ballaire R,Barilla S,Mathew MJ,Toubal A,Fan R,Liang N,Chollet C,Huang Z,Kondili M,Foufelle F,Soprani A,Roussel R,Gautier JF,Alzaid F,Treuter E,Venteclef N

更新日期：2018-09-11 00:00:00

abstract：:Pancreatitis is an inflammatory disease of the exocrine pancreas and ranks among the most common gastrointestinal disorders. Inflamed tissues frequently experience conditions of insufficient oxygen availability, or hypoxia. Here, we demonstrate that hypoxia and consequent stabilization of the hypoxia-inducible factor ...

journal_title：Cell reports

authors： Lee KE,Spata M,Maduka R,Vonderheide RH,Simon MC

更新日期：2018-06-19 00:00:00

abstract：:Premature closure of the sutures that connect the cranial bones during development of the mammalian skull results in a phenotype called craniosynostosis. Recently, several craniosynostosis patients with missense mutations within the gene encoding the interleukin-11 receptor (IL-11R) have been described, but the underl...

journal_title：Cell reports

authors： Agthe M,Brügge J,Garbers Y,Wandel M,Kespohl B,Arnold P,Flynn CM,Lokau J,Aparicio-Siegmund S,Bretscher C,Rose-John S,Waetzig GH,Putoczki T,Grötzinger J,Garbers C

更新日期：2018-10-02 00:00:00

abstract：:The innate immune system plays key roles in tissue regeneration. For example, microglia promote neurogenesis in Müller glia in birds and fish after injury. Although mammalian retina does not normally regenerate, neurogenesis can be induced in mouse Müller glia by Ascl1, a proneural transcription factor. We show that i...

journal_title：Cell reports

authors： Todd L,Finkbeiner C,Wong CK,Hooper MJ,Reh TA

更新日期：2020-12-15 00:00:00

abstract：:Here, we ask how neural stem cells (NSCs) transition in the developing neocortex from a rapidly to a slowly proliferating state, a process required to maintain lifelong stem cell pools. We identify LRIG1, known to regulate receptor tyrosine kinase signaling in other cell types, as a negative regulator of cortical NSC ...

journal_title：Cell reports

authors： Jeong D,Lozano Casasbuenas D,Gengatharan A,Edwards K,Saghatelyan A,Kaplan DR,Miller FD,Yuzwa SA

更新日期：2020-10-13 00:00:00

abstract：:Cytotoxic CD8(+) T lymphocytes play a critical role in the host response to infection by viruses. The ability to secrete cytotoxic chemicals and cytokines is considered pivotal for eliminating virus. Of equal importance is how effector CD8(+) T cells home to virus-infected tissues. L-selectin has not been considered i...

journal_title：Cell reports

authors： Mohammed RN,Watson HA,Vigar M,Ohme J,Thomson A,Humphreys IR,Ager A

更新日期：2016-02-02 00:00:00

abstract：:Mouse embryonic stem cells are dynamic and heterogeneous. For example, rare cells cycle through a state characterized by decondensed chromatin and expression of transcripts, including the Zscan4 cluster and MERVL endogenous retrovirus, which are usually restricted to preimplantation embryos. Here, we further character...

journal_title：Cell reports

authors： Eckersley-Maslin MA,Svensson V,Krueger C,Stubbs TM,Giehr P,Krueger F,Miragaia RJ,Kyriakopoulos C,Berrens RV,Milagre I,Walter J,Teichmann SA,Reik W

更新日期：2016-09-27 00:00:00

abstract：:The INO80 complex (INO80-C) is an evolutionarily conserved nucleosome remodeler that acts in transcription, replication, and genome stability. It is required for resistance against genotoxic agents and is involved in the repair of DNA double-strand breaks (DSBs) by homologous recombination (HR). However, the causes of...

journal_title：Cell reports

authors： Lademann CA,Renkawitz J,Pfander B,Jentsch S

更新日期：2017-05-16 00:00:00

abstract：:The thalamus plays a central role in sleep rhythms in the mammalian brain and, yet, surprisingly little is known about its function and interaction with local cortical oscillations during NREM sleep (NREM). We investigated the neuronal correlates of cortical barrel activity in the two corresponding thalamic nuclei, th...

journal_title：Cell reports

authors： Urbain N,Fourcaud-Trocmé N,Laheux S,Salin PA,Gentet LJ

更新日期：2019-02-05 00:00:00

abstract：:Synapses are fundamental to the normal function of the nervous system. Glia play a pivotal role in regulating synaptic formation. However, how presynaptic neurons assemble synaptic structure in response to the glial signals remains largely unexplored. To address this question, we use cima-1 mutant C. elegans as an in ...

journal_title：Cell reports

authors： Dong X,Jin S,Shao Z

更新日期：2020-02-25 00:00:00

abstract：:Hypoxia-inducible factors (HIFs) are critical regulators of the cellular response to hypoxia. Despite their established roles in normal physiology and numerous pathologies, the molecular mechanisms by which they control gene expression remain poorly understood. We report here a conserved role for the TIP60 complex as ...

journal_title：Cell reports

authors： Perez-Perri JI,Dengler VL,Audetat KA,Pandey A,Bonner EA,Urh M,Mendez J,Daniels DL,Wappner P,Galbraith MD,Espinosa JM

更新日期：2016-06-28 00:00:00

abstract：:Metabolic reprogramming is a hallmark of clear cell renal cell carcinoma (ccRCC) progression. Here, we used genome-scale metabolic modeling to elucidate metabolic reprogramming in 481 ccRCC samples and discovered strongly coordinated regulation of glycosaminoglycan (GAG) biosynthesis at the transcript and protein leve...

journal_title：Cell reports

authors： Gatto F,Volpi N,Nilsson H,Nookaew I,Maruzzo M,Roma A,Johansson ME,Stierner U,Lundstam S,Basso U,Nielsen J

更新日期：2016-05-24 00:00:00

abstract：:Neutrophil polarity relies on local, mutual inhibition to segregate incompatible signaling circuits to the leading and trailing edges. Mutual inhibition alone should lead to cells having strong fronts and weak backs or vice versa. However, analysis of cell-to-cell variation in human neutrophils revealed that back pola...

journal_title：Cell reports

authors： Wang Y,Ku CJ,Zhang ER,Artyukhin AB,Weiner OD,Wu LF,Altschuler SJ

更新日期：2013-05-30 00:00:00

abstract：:Inactivation of the Pten tumor suppressor negatively regulates the PI3K-mTOR pathway. In a model of cutaneous squamous cell carcinoma (SCC), we demonstrate that deletion of Pten strongly elevates Fgf10 protein levels without increasing Fgf10 transcription in vitro and in vivo. The translational activation of Fgf10 by ...

journal_title：Cell reports

authors： Hertzler-Schaefer K,Mathew G,Somani AK,Tholpady S,Kadakia MP,Chen Y,Spandau DF,Zhang X

更新日期：2014-03-13 00:00:00

abstract：:GABAergic synapses in brain circuits generate inhibitory output signals with submillisecond latency and temporal precision. Whether the molecular identity of the release sensor contributes to these signaling properties remains unclear. Here, we examined the Ca2+ sensor of exocytosis at GABAergic basket cell (BC) to Pu...

journal_title：Cell reports

authors： Chen C,Arai I,Satterfield R,Young SM Jr,Jonas P

更新日期：2017-01-17 00:00:00

abstract：:Whereas hundreds of cells in the mouse embryonic aorta transdifferentiate to hematopoietic cells, only very few establish hematopoietic stem cell (HSC) identity at a single time point. The Gata2 transcription factor is essential for HSC generation and function. In contrast to surface-marker-based cell isolation, Gata2...

journal_title：Cell reports

authors： Vink CS,Calero-Nieto FJ,Wang X,Maglitto A,Mariani SA,Jawaid W,Göttgens B,Dzierzak E

更新日期：2020-05-12 00:00:00

abstract：:Emerging evidence suggests that crosstalk between glioma cells and the brain microenvironment may influence brain tumor growth. To date, known reciprocal interactions among these cells have been limited to the release of paracrine factors. Combining a genetic strategy with longitudinal live imaging, we find that indiv...

journal_title：Cell reports

authors： Gao X,Zhang Z,Mashimo T,Shen B,Nyagilo J,Wang H,Wang Y,Liu Z,Mulgaonkar A,Hu XL,Piccirillo SGM,Eskiocak U,Davé DP,Qin S,Yang Y,Sun X,Fu YX,Zong H,Sun W,Bachoo RM,Ge WP

更新日期：2020-02-25 00:00:00

abstract：:53BP1 plays a central role in dictating DNA repair choice between non-homologous end joining (NHEJ) and homologous recombination (HR), which is important for the sensitivity to poly(ADP-ribose) polymerase inhibitors (PARPis) of BRCA1-deficient cancers. In this study, we show that FOXK1 associates with 53BP1 and regula...

journal_title：Cell reports

authors： Tang M,Feng X,Pei G,Srivastava M,Wang C,Chen Z,Li S,Zhang H,Zhao Z,Li X,Chen J

更新日期：2020-08-11 00:00:00

abstract：:Two-photon imaging with genetically encoded calcium indicators (GECIs) enables long-term observation of neuronal activity in vivo. However, there are very few studies of GECIs in primates. Here, we report a method for long-term imaging of a GECI, GCaMP6f, expressed from adeno-associated virus vectors in cortical neuro...

journal_title：Cell reports

authors： Sadakane O,Masamizu Y,Watakabe A,Terada S,Ohtsuka M,Takaji M,Mizukami H,Ozawa K,Kawasaki H,Matsuzaki M,Yamamori T

更新日期：2015-12-01 00:00:00

abstract：:Folates are cofactors for biosynthetic enzymes in all eukaryotic and prokaryotic cells. Animals cannot synthesize folate and must acquire it from their diet or microbiota. Previously, we showed that inhibiting E. coli folate synthesis increases C. elegans lifespan. Here, we show that restriction or supplementation of ...

journal_title：Cell reports

authors： Virk B,Jia J,Maynard CA,Raimundo A,Lefebvre J,Richards SA,Chetina N,Liang Y,Helliwell N,Cipinska M,Weinkove D

更新日期：2016-02-23 00:00:00

abstract：:The development of non-alcoholic fatty liver disease (NAFLD) is a multiple step process. Here, we show that activation of cdk4 triggers the development of NAFLD. We found that cdk4 protein levels are elevated in mouse models of NAFLD and in patients with fatty livers. This increase leads to C/EBPα phosphorylation on S...

journal_title：Cell reports

authors： Jin J,Valanejad L,Nguyen TP,Lewis K,Wright M,Cast A,Stock L,Timchenko L,Timchenko NA

更新日期：2016-07-19 00:00:00

abstract：:Epiblast cells in the early post-implantation stage mammalian embryo undergo a transition described as lineage priming before cell fate allocation, but signaling pathways acting upstream remain ill defined. Genetic studies demonstrate that Smad2/3 double-mutant mouse embryos die shortly after implantation. To learn mo...

journal_title：Cell reports

authors： Senft AD,Costello I,King HW,Mould AW,Bikoff EK,Robertson EJ

更新日期：2018-08-21 00:00:00

abstract：:We explored the role of the Krebs cycle enzyme fumarate hydratase (FH) in glucose-stimulated insulin secretion (GSIS). Mice lacking Fh1 in pancreatic β cells (Fh1βKO mice) appear normal for 6-8 weeks but then develop progressive glucose intolerance and diabetes. Glucose tolerance is rescued by expression of mitochondr...

journal_title：Cell reports

authors： Adam J,Ramracheya R,Chibalina MV,Ternette N,Hamilton A,Tarasov AI,Zhang Q,Rebelato E,Rorsman NJG,Martín-Del-Río R,Lewis A,Özkan G,Do HW,Spégel P,Saitoh K,Kato K,Igarashi K,Kessler BM,Pugh CW,Tamarit-Rodriguez J,Mu

更新日期：2017-09-26 00:00:00

abstract：:Kappa opioid receptors (KORs) are involved in a variety of aversive behavioral states, including anxiety. To date, a circuit-based mechanism for KOR-driven anxiety has not been described. Here, we show that activation of KORs inhibits glutamate release from basolateral amygdala (BLA) inputs to the bed nucleus of the s...

journal_title：Cell reports

authors： Crowley NA,Bloodgood DW,Hardaway JA,Kendra AM,McCall JG,Al-Hasani R,McCall NM,Yu W,Schools ZL,Krashes MJ,Lowell BB,Whistler JL,Bruchas MR,Kash TL

更新日期：2016-03-29 00:00:00

abstract：:The Fanconi anemia (FA) pathway repairs DNA interstrand crosslinks (ICLs). Many FA proteins are recruited to ICLs in a timely fashion so that coordinated repair can occur. However, the mechanism of this process is poorly understood. Here, we report the purification of a FANCD2-containing protein complex with multiple ...

journal_title：Cell reports

authors： Socha A,Yang D,Bulsiewicz A,Yaprianto K,Kupculak M,Liang CC,Hadjicharalambous A,Wu R,Gygi SP,Cohn MA

更新日期：2020-07-07 00:00:00

abstract：:Gambogic acid (GA) is a natural compound derived from Chinese herbs that has been approved by the Chinese Food and Drug Administration for clinical trials in cancer patients; however, its molecular targets have not been thoroughly studied. Here, we report that GA inhibits tumor proteasome activity, with potency compar...

journal_title：Cell reports

authors： Li X,Liu S,Huang H,Liu N,Zhao C,Liao S,Yang C,Liu Y,Zhao C,Li S,Lu X,Liu C,Guan L,Zhao K,Shi X,Song W,Zhou P,Dong X,Guo H,Wen G,Zhang C,Jiang L,Ma N,Li B,Wang S,Tan H,Wang X,Dou QP,Liu J

更新日期：2013-01-31 00:00:00

abstract：:The architecture of renal glomeruli is acquired through intricate and still poorly understood developmental steps. In our study we identify a crucial glomerular morphogenetic event in nephrogenesis that drives the remodeling/separation of the prospective vascular pole (the future entrance of the glomerular arterioles)...

journal_title：Cell reports

authors： Fiorentino A,Christophorou A,Massa F,Garbay S,Chiral M,Ramsing M,Rasmussen M,Gubler MC,Bessieres B,Heidet L,Fischer E,Pontoglio M

更新日期：2020-10-27 00:00:00

abstract：:Complex architectural rearrangements are associated to the control of the HoxD genes in different cell types; yet, how they are implemented in single cells remains unknown. By use of polymer models, we dissect the locus 3D structure at the single DNA molecule level in mouse embryonic stem and cortical neuronal cells, ...

journal_title：Cell reports

authors： Bianco S,Annunziatella C,Andrey G,Chiariello AM,Esposito A,Fiorillo L,Prisco A,Conte M,Campanile R,Nicodemi M

更新日期：2019-08-06 00:00:00