WRNIP1 Is Recruited to DNA Interstrand Crosslinks and Promotes Repair.

abstract：:Glucagon-like peptide-1 receptor (GLP-1R) agonists used to treat type 2 diabetes mellitus often produce nausea, vomiting, and in some patients, undesired anorexia. Notably, these behavioral effects are caused by direct central GLP-1R activation. Herein, we describe the creation of a GLP-1R agonist conjugate with modif...

journal_title：Cell reports

authors： Borner T,Workinger JL,Tinsley IC,Fortin SM,Stein LM,Chepurny OG,Holz GG,Wierzba AJ,Gryko D,Nexø E,Shaulson ED,Bamezai A,Da Silva VAR,De Jonghe BC,Hayes MR,Doyle RP

更新日期：2020-06-16 00:00:00

abstract：:Quiescence is a fundamental property of adult stem cells. Recent evidence indicates that quiescence is not a default state but requires active signaling that prevents accidental or untimely activation of stem cells. The calcitonin receptor (CalcR) is critical for sustaining quiescence in muscle satellite (stem) cells ...

journal_title：Cell reports

authors： Zhang L,Noguchi YT,Nakayama H,Kaji T,Tsujikawa K,Ikemoto-Uezumi M,Uezumi A,Okada Y,Doi T,Watanabe S,Braun T,Fujio Y,Fukada SI

更新日期：2019-11-19 00:00:00

abstract：:Chronic itch or pruritus is a debilitating disorder that is refractory to conventional anti-histamine treatment. Kappa opioid receptor (KOR) agonists have been used to treat chronic itch, but the underlying mechanism remains elusive. Here, we find that KOR and gastrin-releasing peptide receptor (GRPR) overlap in the s...

journal_title：Cell reports

authors： Munanairi A,Liu XY,Barry DM,Yang Q,Yin JB,Jin H,Li H,Meng QT,Peng JH,Wu ZY,Yin J,Zhou XY,Wan L,Mo P,Kim S,Huo FQ,Jeffry J,Li YQ,Bardoni R,Bruchas MR,Chen ZF

更新日期：2018-04-17 00:00:00

abstract：:Mutations of WD40-repeat protein 62 (WDR62) have been identified recently to cause human MCPH (autosomal-recessive primary microcephaly), a neurodevelopmental disorder characterized by decreased brain size. However, the underlying mechanism is unclear. Here, we investigate the function of WDR62 in brain development an...

journal_title：Cell reports

authors： Xu D,Zhang F,Wang Y,Sun Y,Xu Z

更新日期：2014-01-16 00:00:00

abstract：:The MYC proto-oncogene is a transcription factor implicated in a broad range of cancers. MYC is regulated by several post-translational modifications including SUMOylation, but the functional impact of this post-translational modification is still unclear. Here, we report that the SUMO E3 ligase PIAS1 SUMOylates MYC. ...

journal_title：Cell reports

authors： Rabellino A,Melegari M,Tompkins VS,Chen W,Van Ness BG,Teruya-Feldstein J,Conacci-Sorrell M,Janz S,Scaglioni PP

更新日期：2016-06-07 00:00:00

abstract：:Despite recent progress in engineering native trimeric HIV-1 envelope glycoprotein (Env) mimics as vaccine candidates, Env trimers often induce vaccine-matched neutralizing antibody (NAb) responses. Understanding the specificities of autologous NAb responses and the underlying molecular mechanisms restricting the neut...

journal_title：Cell reports

authors： Lei L,Yang YR,Tran K,Wang Y,Chiang CI,Ozorowski G,Xiao Y,Ward AB,Wyatt RT,Li Y

更新日期：2019-04-09 00:00:00

abstract：:CELF6 is a CELF-RNA-binding protein, and thus part of a protein family with roles in human disease; however, its mRNA targets in the brain are largely unknown. Using cross-linking immunoprecipitation and sequencing (CLIP-seq), we define its CNS targets, which are enriched for 3' UTRs in synaptic protein-coding genes. ...

journal_title：Cell reports

authors： Rieger MA,King DM,Crosby H,Liu Y,Cohen BA,Dougherty JD

更新日期：2020-12-22 00:00:00

abstract：:Understanding how peptide selection is controlled on different major histocompatibility complex class I (MHC I) molecules is pivotal for determining how variations in these proteins influence our predisposition to infectious diseases, cancer, and autoinflammatory conditions. Although the intracellular chaperone TAPBPR...

journal_title：Cell reports

authors： Ilca FT,Drexhage LZ,Brewin G,Peacock S,Boyle LH

更新日期：2019-11-05 00:00:00

abstract：:Interleukin (IL)-17 signaling to the intestinal epithelium regulates the intestinal microbiome. Given the reported links between intestinal dysbiosis, bacterial translocation, and liver disease, we hypothesize that intestinal IL-17R signaling plays a critical role in mitigating hepatic inflammation. To test this, we s...

journal_title：Cell reports

authors： Castillo-Dela Cruz P,Wanek AG,Kumar P,An X,Elsegeiny W,Horne W,Fitch A,Burr AHP,Gopalakrishna KP,Chen K,Methé BA,Canna SW,Hand TW,Kolls JK

更新日期：2019-11-19 00:00:00

abstract：:Apolipoprotein M (apoM) is the carrier of sphingosine-1-phosphate (S1P) in plasma high-density lipoproteins. S1P is a bioactive lipid interacting with five receptors (S1P1-5). We show that lack of apoM in mice increases the amount of brown adipose tissue (BAT), accelerates the clearance of postprandial triglycerides, ...

journal_title：Cell reports

authors： Christoffersen C,Federspiel CK,Borup A,Christensen PM,Madsen AN,Heine M,Nielsen CH,Kjaer A,Holst B,Heeren J,Nielsen LB

更新日期：2018-01-02 00:00:00

abstract：:5-methylcytosine (5mC) is converted to 5-hydroxymethylcytosine (5hmC) by the TET family of enzymes as part of a recently discovered active DNA de-methylation pathway. 5hmC plays important roles in regulation of gene expression and differentiation and has been implicated in T cell malignancies and autoimmunity. Here, w...

journal_title：Cell reports

authors： Nestor CE,Lentini A,Hägg Nilsson C,Gawel DR,Gustafsson M,Mattson L,Wang H,Rundquist O,Meehan RR,Klocke B,Seifert M,Hauck SM,Laumen H,Zhang H,Benson M

更新日期：2016-07-12 00:00:00

abstract：:Inability to mediate fed-fast transitions in the liver is known to cause metabolic dysfunctions and diseases. Intuitively, a failure to inhibit futile translation of state-specific transcripts during fed-fast cycles would abrogate dynamic physiological transitions. Here, we have discovered hepatic fed microRNAs that t...

journal_title：Cell reports

authors： Maniyadath B,Chattopadhyay T,Verma S,Kumari S,Kulkarni P,Banerjee K,Lazarus A,Kokane SS,Shetty T,Anamika K,Kolthur-Seetharam U

更新日期：2019-02-19 00:00:00

abstract：:Polyunsaturated fatty acids (PUFAs) confer health benefits by preventing inflammation and obesity and by increasing thermogenesis in brown and beige adipocytes. As well as being supplied exogenously as nutrients, PUFAs are largely stored in membrane glycerophospholipids and released by phospholipase A2s (PLA2s). Howev...

journal_title：Cell reports

authors： Sato H,Taketomi Y,Miki Y,Murase R,Yamamoto K,Murakami M

更新日期：2020-05-05 00:00:00

abstract：:Microbes have shown a remarkable ability in evading the killing actions of antimicrobial agents, such that treatment of bacterial infections represents once more an urgent global challenge. Understanding the initial bacterial response to antimicrobials may reveal intrinsic tolerance mechanisms to antibiotics and sugge...

journal_title：Cell reports

authors： Zampieri M,Zimmermann M,Claassen M,Sauer U

更新日期：2017-05-09 00:00:00

abstract：:The proneural transcription factor Ascl1 coordinates gene expression in both proliferating and differentiating progenitors along the neuronal lineage. Here, we used a cellular model of neurogenesis to investigate how Ascl1 interacts with the chromatin landscape to regulate gene expression when promoting neuronal diffe...

journal_title：Cell reports

authors： Raposo AASF,Vasconcelos FF,Drechsel D,Marie C,Johnston C,Dolle D,Bithell A,Gillotin S,van den Berg DLC,Ettwiller L,Flicek P,Crawford GE,Parras CM,Berninger B,Buckley NJ,Guillemot F,Castro DS

更新日期：2015-03-10 00:00:00

abstract：:HIV-1 Tat activates viral transcription and limited Tat transactivation correlates with latency establishment. We postulated a "block-and-lock" functional cure approach based on properties of the Tat inhibitor didehydro-Cortistatin A (dCA). HIV-1 transcriptional inhibitors could block ongoing viremia during antiretrov...

journal_title：Cell reports

authors： Kessing CF,Nixon CC,Li C,Tsai P,Takata H,Mousseau G,Ho PT,Honeycutt JB,Fallahi M,Trautmann L,Garcia JV,Valente ST

更新日期：2017-10-17 00:00:00

abstract：:Herein, we demonstrate that HCMV miR-UL112-5p targets ERAP1, thereby inhibiting the processing and presentation of the HCMV pp65495-503 peptide to specific CTLs. In addition, we show that the rs17481334 G variant, naturally occurring in the ERAP1 3' UTR, preserves ERAP1 from miR-UL112-5p-mediated degradation. Specific...

journal_title：Cell reports

authors： Romania P,Cifaldi L,Pignoloni B,Starc N,D'Alicandro V,Melaiu O,Li Pira G,Giorda E,Carrozzo R,Bergvall M,Bergström T,Alfredsson L,Olsson T,Kockum I,Seppälä I,Lehtimäki T,Hurme MA,Hengel H,Santoni A,Cerboni C,Locate

更新日期：2017-07-25 00:00:00

abstract：:The circadian clock generates biological rhythms of metabolic and physiological processes, including the sleep-wake cycle. We previously identified a missense mutation in the flavin adenine dinucleotide (FAD) binding pocket of CRYPTOCHROME2 (CRY2), a clock protein that causes human advanced sleep phase. This prompted ...

journal_title：Cell reports

authors： Hirano A,Braas D,Fu YH,Ptáček LJ

更新日期：2017-04-11 00:00:00

abstract：:Uveal melanoma (UM) is characterized by mutually exclusive activating mutations in GNAQ, GNA11, CYSLTR2, and PLCB4, four genes in a linear pathway to activation of PLCβ in almost all tumors and loss of BAP1 in the aggressive subset. We generated mice with melanocyte-specific expression of GNA11Q209L with and without h...

journal_title：Cell reports

authors： Moore AR,Ran L,Guan Y,Sher JJ,Hitchman TD,Zhang JQ,Hwang C,Walzak EG,Shoushtari AN,Monette S,Murali R,Wiesner T,Griewank KG,Chi P,Chen Y

更新日期：2018-02-27 00:00:00

abstract：:Coordinate control of T cell proliferation, survival, and differentiation are essential for host protection from pathogens and cancer. Long-lived memory cells, whose precursors are formed during the initial immunological insult, provide protection from future encounters, and their generation is the goal of many vaccin...

journal_title：Cell reports

authors： Gagnon JD,Kageyama R,Shehata HM,Fassett MS,Mar DJ,Wigton EJ,Johansson K,Litterman AJ,Odorizzi P,Simeonov D,Laidlaw BJ,Panduro M,Patel S,Jeker LT,Feeney ME,McManus MT,Marson A,Matloubian M,Sanjabi S,Ansel KM

更新日期：2019-08-20 00:00:00

abstract：:RNA viruses have specific mutation rates that balance the conflicting needs of an evolutionary response to host antiviral defenses and avoidance of the error catastrophe. While most mutations are known to originate in replication errors, difficulties of capturing the underlying dynamics have left the mechanochemical b...

journal_title：Cell reports

authors： Dulin D,Vilfan ID,Berghuis BA,Hage S,Bamford DH,Poranen MM,Depken M,Dekker NH

更新日期：2015-02-17 00:00:00

abstract：:Small cytoplasmic mRNP granules are implicated in mRNA transport, translational control, and decay. Using super-resolution microscopy and fluorescence correlation spectroscopy, we analyzed the molecular composition and dynamics of single cytoplasmic YBX1_IMP1 mRNP granules in live cells. Granules appeared elongated an...

journal_title：Cell reports

authors： Mateu-Regué À,Christiansen J,Bagger FO,Winther O,Hellriegel C,Nielsen FC

更新日期：2019-10-15 00:00:00

abstract：:Soluble envelope (Env) trimers, stabilized in a prefusion-closed conformation, can elicit neutralizing responses against HIV-1 strains closely related to the immunizing trimer. However, to date such stabilization has succeeded with only a limited number of HIV-1 strains. To address this issue, here we develop ADROITri...

journal_title：Cell reports

authors： Rawi R,Rutten L,Lai YT,Olia AS,Blokland S,Juraszek J,Shen CH,Tsybovsky Y,Verardi R,Yang Y,Zhang B,Zhou T,Chuang GY,Kwong PD,Langedijk JPM

更新日期：2020-11-24 00:00:00

abstract：:Presenilin 1 (PS1) is the catalytic core of γ-secretase, which cleaves type 1 transmembrane proteins, including the amyloid precursor protein (APP). PS1 also has γ-secretase-independent functions, and dominant PS1 missense mutations are the most common cause of familial Alzheimer's disease (FAD). Whether PS1 FAD mutat...

journal_title：Cell reports

authors： Woodruff G,Young JE,Martinez FJ,Buen F,Gore A,Kinaga J,Li Z,Yuan SH,Zhang K,Goldstein LS

更新日期：2013-11-27 00:00:00

abstract：:In mammals, a cell's decision to divide is thought to be under the control of the Rb/E2F pathway. We previously found that inactivation of the Rb family of cell cycle inhibitors (Rb, p107, and p130) in quiescent liver progenitors leads to uncontrolled division and cancer initiation. Here, we show that, in contrast, de...

journal_title：Cell reports

authors： Ehmer U,Zmoos AF,Auerbach RK,Vaka D,Butte AJ,Kay MA,Sage J

更新日期：2014-07-24 00:00:00

abstract：:Increased calpain activity is linked to neuroinflammation including a heritable retinal disease caused by hyper-activating mutations in the calcium-activated calpain-5 (CAPN5) protease. Although structures for classical calpains are known, the structure of CAPN5, a non-classical calpain, remains undetermined. Here we ...

journal_title：Cell reports

authors： Velez G,Sun YJ,Khan S,Yang J,Herrmann J,Chemudupati T,MacLaren RE,Gakhar L,Wakatsuki S,Bassuk AG,Mahajan VB

更新日期：2020-01-21 00:00:00

abstract：:Mutations in WNK kinases cause the human hypertensive disease pseudohypoaldosteronism type II (PHAII), but the regulatory mechanisms of the WNK kinases are not well understood. Mutations in kelch-like 3 (KLHL3) and Cullin3 were also recently identified as causing PHAII. Therefore, new insights into the mechanisms of h...

journal_title：Cell reports

authors： Wakabayashi M,Mori T,Isobe K,Sohara E,Susa K,Araki Y,Chiga M,Kikuchi E,Nomura N,Mori Y,Matsuo H,Murata T,Nomura S,Asano T,Kawaguchi H,Nonoyama S,Rai T,Sasaki S,Uchida S

更新日期：2013-03-28 00:00:00

abstract：:Gambogic acid (GA) is a natural compound derived from Chinese herbs that has been approved by the Chinese Food and Drug Administration for clinical trials in cancer patients; however, its molecular targets have not been thoroughly studied. Here, we report that GA inhibits tumor proteasome activity, with potency compar...

journal_title：Cell reports

authors： Li X,Liu S,Huang H,Liu N,Zhao C,Liao S,Yang C,Liu Y,Zhao C,Li S,Lu X,Liu C,Guan L,Zhao K,Shi X,Song W,Zhou P,Dong X,Guo H,Wen G,Zhang C,Jiang L,Ma N,Li B,Wang S,Tan H,Wang X,Dou QP,Liu J

更新日期：2013-01-31 00:00:00

abstract：:Antiangiogenic therapy is commonly used in the clinic, but its beneficial effects are short-lived, leading to tumor relapse within months. Here, we found that the efficacy of angiogenic inhibitors targeting the VEGF/VEGFR pathway was dependent on induction of the angiostatic and immune-stimulatory chemokine CXCL14 in ...

journal_title：Cell reports

authors： Rivera LB,Meyronet D,Hervieu V,Frederick MJ,Bergsland E,Bergers G

更新日期：2015-04-28 00:00:00

abstract：:ATP citrate lyase (ACL) plays a key role in regulating mitochondrial function, as well as glucose and lipid metabolism in skeletal muscle. We report here that ACL silencing impairs myoblast and satellite cell (SC) differentiation, and it is accompanied by a decrease in fast myosin heavy chain isoforms and MYOD. Conver...

journal_title：Cell reports

authors： Das S,Morvan F,Morozzi G,Jourde B,Minetti GC,Kahle P,Rivet H,Brebbia P,Toussaint G,Glass DJ,Fornaro M

更新日期：2017-12-12 00:00:00