Abstract：
:The thalamus plays a central role in sleep rhythms in the mammalian brain and, yet, surprisingly little is known about its function and interaction with local cortical oscillations during NREM sleep (NREM). We investigated the neuronal correlates of cortical barrel activity in the two corresponding thalamic nuclei, the ventral posterior medial (VPM), and the posterior medial (Pom) nuclei during natural NREM in mice. Our data reveal (1) distinct modulations of VPM and Pom activity throughout NREM episodes, (2) a thalamic nucleus-specific phase-locking to cortical slow and spindle waves, (3) cell-specific subthreshold spindle oscillations in VPM neurons that only partially overlap with cortical spindles, and (4) that spindle features evolve throughout NREM episodes and vary according to the post-NREM state. Taken together, our results suggest that, during natural sleep, the barrel cortex exerts a leading role in the generation and transfer of slow rhythms to the somatosensory thalamus and reciprocally for spindle oscillations.
journal_name
Cell Repjournal_title
Cell reportsauthors
Urbain N,Fourcaud-Trocmé N,Laheux S,Salin PA,Gentet LJdoi
10.1016/j.celrep.2019.01.038subject
Has Abstractpub_date
2019-02-05 00:00:00pages
1443-1457.e5issue
6issn
2211-1247pii
S2211-1247(19)30056-7journal_volume
26pub_type
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