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Glia Promote Synaptogenesis through an IQGAP PES-7 in C. elegans.

Abstract：

:Synapses are fundamental to the normal function of the nervous system. Glia play a pivotal role in regulating synaptic formation. However, how presynaptic neurons assemble synaptic structure in response to the glial signals remains largely unexplored. To address this question, we use cima-1 mutant C. elegans as an in vivo model, in which the astrocyte-like VCSC glial processes ectopically reach an asynaptic neurite region and promote presynaptic formation there. Through an RNAi screen, we find that the Rho GTPase CDC-42 and IQGAP PES-7 are required in presynaptic neurons for VCSC glia-induced presynaptic formation. In addition, we find that cdc-42 and pes-7 are also required for normal synaptogenesis during postembryonic developmental stages. PES-7 activated by CDC-42 promotes presynaptic formation, most likely through regulating F-actin assembly. Given the evolutionary conservation of CDC-42 and IQGAPs, we speculate that our findings in C. elegans apply to vertebrates.

journal_name

Cell Rep

journal_title

Cell reports

authors

Dong X,Jin S,Shao Z

doi

10.1016/j.celrep.2020.01.102

subject

Has Abstract

pub_date

2020-02-25 00:00:00

pages

2614-2626.e2

issue

8

issn

2211-1247

pii

S2211-1247(20)30136-4

journal_volume

30

pub_type

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