Intestine-to-Germline Transmission of Epigenetic Information Intergenerationally Ensures Systemic Stress Resistance in C. elegans.

abstract：:As three-dimensional cell culture formats gain in popularity, there emerges a need for tools that produce vast amounts of data on individual cells within the spheroids or organoids. Here, we present a microfluidic platform that provides access to such data by parallelizing the manipulation of individual spheroids with...

journal_title：Cell reports

authors： Tomasi RF,Sart S,Champetier T,Baroud CN

更新日期：2020-05-26 00:00:00

abstract：:Spontaneous neurotransmitter release is a core element of synaptic communication in mature neurons, but despite exceptionally high levels of spontaneous vesicle cycling occurring in developing axons, little is known of its function during this period. We now show that high-level, spontaneous axonal release of the neur...

journal_title：Cell reports

authors： Andreae LC,Burrone J

更新日期：2015-02-17 00:00:00

abstract：:Insulin-stimulated hepatic glycogen synthesis is central to glucose homeostasis. Here, we show that PPP1R3G, a regulatory subunit of protein phosphatase 1 (PP1), is directly phosphorylated by AKT. PPP1R3G phosphorylation fluctuates with fasting-refeeding cycle and is required for insulin-stimulated dephosphorylation, ...

journal_title：Cell reports

authors： Li Q,Zhao Q,Zhang J,Zhou L,Zhang W,Chua B,Chen Y,Xu L,Li P

更新日期：2019-09-24 00:00:00

abstract：:High-throughput imaging has led to an explosion of observations about cell-size homeostasis across the kingdoms of life. Among bacteria, "adder" behavior-in which a constant size increment appears to be added during each cell cycle-is ubiquitous, while various eukaryotes show other size-homeostasis behaviors. Since in...

journal_title：Cell reports

authors： Willis L,Jönsson H,Huang KC

更新日期：2020-08-11 00:00:00

abstract：:Chemogenetics enables manipulation of neuronal activity in experimental animals. While providing information about the transduced neuron expressing a ligand-activated molecule, chemogenetics does not provide understanding about the antecedent circuit that drives that neuron's activity. For current approaches, this is ...

journal_title：Cell reports

authors： Ngo HB,Melo MR,Layfield S,Connelly AA,Bassi JK,Xie L,Menuet C,McDougall SJ,Bathgate RAD,Allen AM

更新日期：2020-09-15 00:00:00

abstract：:Dysfunction of microglia, the tissue macrophages of the brain, has been associated with the etiology of several neuropsychiatric disorders. Consistently, microglia have been shown to regulate neurogenesis and synaptic maturation at perinatal and postnatal stages. However, microglia invade the brain during mid-embryoge...

journal_title：Cell reports

authors： Squarzoni P,Oller G,Hoeffel G,Pont-Lezica L,Rostaing P,Low D,Bessis A,Ginhoux F,Garel S

更新日期：2014-09-11 00:00:00

abstract：:Lymphatic vascular development establishes embryonic and adult tissue fluid balance and is integral in disease. In diverse vertebrate organs, lymphatic vessels display organotypic function and develop in an organ-specific manner. In all settings, developmental lymphangiogenesis is considered driven by vascular endothe...

journal_title：Cell reports

authors： Vogrin AJ,Bower NI,Gunzburg MJ,Roufail S,Okuda KS,Paterson S,Headey SJ,Stacker SA,Hogan BM,Achen MG

更新日期：2019-08-20 00:00:00

abstract：:5-methylcytosine (5mC) is converted to 5-hydroxymethylcytosine (5hmC) by the TET family of enzymes as part of a recently discovered active DNA de-methylation pathway. 5hmC plays important roles in regulation of gene expression and differentiation and has been implicated in T cell malignancies and autoimmunity. Here, w...

journal_title：Cell reports

authors： Nestor CE,Lentini A,Hägg Nilsson C,Gawel DR,Gustafsson M,Mattson L,Wang H,Rundquist O,Meehan RR,Klocke B,Seifert M,Hauck SM,Laumen H,Zhang H,Benson M

更新日期：2016-07-12 00:00:00

abstract：:After implantation, pluripotent epiblasts are converted to embryonic ectoderm through cell-cell interactions that significantly change the transcriptional and epigenetic networks. An entrée to understanding this vital developmental transition is the t(w5) mutation of the mouse t complex. This mutation produces highly ...

journal_title：Cell reports

authors： Sugimoto M,Kondo M,Hirose M,Suzuki M,Mekada K,Abe T,Kiyonari H,Ogura A,Takagi N,Artzt K,Abe K

更新日期：2012-11-29 00:00:00

abstract：:Residual cell-intrinsic innate immunity in cancer cells hampers infection with oncolytic viruses. Translational control of mRNA is an important feature of innate immunity, yet the identity of translationally regulated mRNAs functioning in host defense remains ill-defined. We report the translatomes of resistant murine...

journal_title：Cell reports

authors： Hoang HD,Graber TE,Jia JJ,Vaidya N,Gilchrist VH,Xiang X,Li W,Cowan KN,Gkogkas CG,Jaramillo M,Jafarnejad SM,Alain T

更新日期：2019-12-17 00:00:00

abstract：:Nonalcoholic fatty liver disease is the most common chronic liver disorder in developed countries. Its pathogenesis is poorly understood, and therapeutic options are limited. Here, we show that SIRT7, an NAD(+)-dependent H3K18Ac deacetylase, functions at chromatin to suppress ER stress and prevent the development of f...

journal_title：Cell reports

authors： Shin J,He M,Liu Y,Paredes S,Villanova L,Brown K,Qiu X,Nabavi N,Mohrin M,Wojnoonski K,Li P,Cheng HL,Murphy AJ,Valenzuela DM,Luo H,Kapahi P,Krauss R,Mostoslavsky R,Yancopoulos GD,Alt FW,Chua KF,Chen D

更新日期：2013-11-14 00:00:00

abstract：:In eukaryotic cells, inefficient splicing is surprisingly common and leads to the degradation of transcripts with retained introns. How pre-mRNAs are committed to nuclear decay is unknown. Here, we uncover a mechanism by which specific intron-containing transcripts are targeted for nuclear degradation in fission yeast...

journal_title：Cell reports

authors： Kilchert C,Wittmann S,Passoni M,Shah S,Granneman S,Vasiljeva L

更新日期：2015-12-22 00:00:00

abstract：:DNA wrapping around histone octamers generates nucleosomes, the basic compaction unit of eukaryotic chromatin. Nucleosome stability is carefully tuned to maintain DNA accessibility in transcription, replication, and repair. Using freely orbiting magnetic tweezers, which measure the twist and length of single DNA molec...

journal_title：Cell reports

authors： Vlijm R,Lee M,Lipfert J,Lusser A,Dekker C,Dekker NH

更新日期：2015-01-13 00:00:00

abstract：:G-protein-coupled receptors (GPCRs) constitute the largest superfamily of cell-surface signaling proteins. However, mechanisms underlying their surface targeting and sorting are poorly understood. Here, we screen the Rab family of small GTPases in the surface transport of multiple GPCRs. We find that manipulation of R...

journal_title：Cell reports

authors： Li C,Wei Z,Fan Y,Huang W,Su Y,Li H,Dong Z,Fukuda M,Khater M,Wu G

更新日期：2017-10-24 00:00:00

abstract：:Zinc-finger E-box binding homeobox 1 (Zeb1) is a key regulator of epithelial-mesenchymal transition and cancer metastasis. Mutation of ZEB1 is associated with human diseases and defective brain development. Here we show that downregulation of Zeb1 expression in embryonic cortical neural progenitor cells (NPCs) is nece...

journal_title：Cell reports

authors： Wang H,Xiao Z,Zheng J,Wu J,Hu XL,Yang X,Shen Q

更新日期：2019-05-21 00:00:00

abstract：:The Fanconi anemia (FA) pathway repairs DNA interstrand crosslinks (ICLs). Many FA proteins are recruited to ICLs in a timely fashion so that coordinated repair can occur. However, the mechanism of this process is poorly understood. Here, we report the purification of a FANCD2-containing protein complex with multiple ...

journal_title：Cell reports

authors： Socha A,Yang D,Bulsiewicz A,Yaprianto K,Kupculak M,Liang CC,Hadjicharalambous A,Wu R,Gygi SP,Cohn MA

更新日期：2020-07-07 00:00:00

abstract：:The Hippo signaling pathway maintains organ size and tissue homeostasis via orchestration of cell proliferation and apoptosis. How this pathway triggers cell apoptosis remains largely unexplored. Here, we identify NR4A1 as a target of the Hippo pathway that mediates the pro-apoptotic and anti-tumor effects of the Hipp...

journal_title：Cell reports

authors： He L,Yuan L,Yu W,Sun Y,Jiang D,Wang X,Feng X,Wang Z,Xu J,Yang R,Zhang W,Feng H,Chen HZ,Zeng YA,Hui L,Wu Q,Zhang Y,Zhang L

更新日期：2020-10-20 00:00:00

abstract：:53BP1 plays multiple roles in mammalian DNA damage repair, mediating pathway choice and facilitating DNA double-strand break repair in heterochromatin. Although it possesses a C-terminal BRCT2 domain, commonly involved in phospho-peptide binding in other proteins, initial recruitment of 53BP1 to sites of DNA damage de...

journal_title：Cell reports

authors： Baldock RA,Day M,Wilkinson OJ,Cloney R,Jeggo PA,Oliver AW,Watts FZ,Pearl LH

更新日期：2015-12-15 00:00:00

abstract：:The asymmetric distribution of auxin leads to the bending growth of hypocotyls during gravitropic and phototropic responses, but the signaling events downstream of auxin remain unclear. Here, we identify many SAUR genes showing asymmetric expression in soybean hypocotyls during gravistimulation and then study their ho...

journal_title：Cell reports

authors： Wang X,Yu R,Wang J,Lin Z,Han X,Deng Z,Fan L,He H,Deng XW,Chen H

更新日期：2020-04-21 00:00:00

abstract：:Reduced eukaryotic Initiation Factor 2 (eIF2)α phosphorylation (p-eIF2α) enhances protein synthesis, memory formation, and addiction-like behaviors. However, p-eIF2α has not been examined with regard to psychoactive cannabinoids and cross-sensitization. Here, we find that a cannabinoid receptor agonist (WIN 55,212-2 m...

journal_title：Cell reports

authors： Melas PA,Qvist JS,Deidda M,Upreti C,Wei YB,Sanna F,Fratta W,Scherma M,Fadda P,Kandel DB,Kandel ER

更新日期：2018-03-13 00:00:00

abstract：:Sensory information is selectively or non-selectively enhanced and inhibited in the brain, but it remains unclear whether and how this occurs at the most peripheral level. Using in vivo calcium imaging of mouse olfactory bulb and olfactory epithelium in wild-type and mutant animals, we show that odors produce not only...

journal_title：Cell reports

authors： Inagaki S,Iwata R,Iwamoto M,Imai T

更新日期：2020-06-30 00:00:00

abstract：:Although it is well established that tumor-associated macrophages take part in each step of cancer progression, less is known about the distinct role of the so-called metastasis-associated macrophages (MAMs) at the metastatic site. Previous studies reported that Caveolin-1 (Cav1) has both tumor-promoting and tumor-sup...

journal_title：Cell reports

authors： Celus W,Di Conza G,Oliveira AI,Ehling M,Costa BM,Wenes M,Mazzone M

更新日期：2017-12-05 00:00:00

abstract：:Neutrophils are short-lived blood cells that play a critical role in host defense against infections. To better comprehend neutrophil functions and their regulation, we provide a complete epigenetic overview, assessing important functional features of their differentiation stages from bone marrow-residing progenitors ...

journal_title：Cell reports

authors： Grassi L,Pourfarzad F,Ullrich S,Merkel A,Were F,Carrillo-de-Santa-Pau E,Yi G,Hiemstra IH,Tool ATJ,Mul E,Perner J,Janssen-Megens E,Berentsen K,Kerstens H,Habibi E,Gut M,Yaspo ML,Linser M,Lowy E,Datta A,Clarke L,F

更新日期：2018-09-04 00:00:00

abstract：:Self-reactive CD4 T cells are incompletely deleted during thymic development, and their peripheral seeding highlights the need for additional safeguards to avert autoimmunity. Here, we show an essential role for the coinhibitory molecule programmed death-1 (PD-1) in silencing the activation of high-affinity autoreacti...

journal_title：Cell reports

authors： Jiang TT,Martinov T,Xin L,Kinder JM,Spanier JA,Fife BT,Way SS

更新日期：2016-11-08 00:00:00

abstract：:Several pattern-recognition receptors sense HIV-1 replication products and induce type I interferon (IFN-I) production under specific experimental conditions. However, it is thought that viral sensing and IFN induction are virtually absent in the main target cells of HIV-1 in vivo. Here, we show that activated CD4+ T ...

journal_title：Cell reports

authors： Vermeire J,Roesch F,Sauter D,Rua R,Hotter D,Van Nuffel A,Vanderstraeten H,Naessens E,Iannucci V,Landi A,Witkowski W,Baeyens A,Kirchhoff F,Verhasselt B

更新日期：2016-10-04 00:00:00

abstract：:Two hallmarks of cancer cells are their resistance to apoptosis and ability to thrive despite reduced levels of vital serum components. c-jun N-terminal kinase (JNK) activation is crucial for apoptosis triggered by serum starvation (SS), and isocitrate dehydrogenase 1 (IDH1) mutations are tumorigenic, in part, because...

journal_title：Cell reports

authors： Jiang B,Zhang J,Xia J,Zhao W,Wu Y,Shi M,Luo L,Zhou H,Chen A,Ma H,Zhao Q,Suleman M,Lin F,Zhou L,Wang J,Zhang Y,He Y,Li X,Hung LM,Mak TW,Li Q

更新日期：2017-04-11 00:00:00

abstract：:The yeast protein Ipa1 was recently discovered to interact with the Ysh1 endonuclease of the pre-mRNA cleavage and polyadenylation (C/P) machinery, and Ipa1 mutation impairs 3'end processing. We report that Ipa1 globally promotes proper transcription termination and poly(A) site selection, but with variable effects on...

journal_title：Cell reports

authors： Pearson EL,Graber JH,Lee SD,Naggert KS,Moore CL

更新日期：2019-02-12 00:00:00

abstract：:Mucus separates gut-luminal microbes from the tissue. It is unclear how pathogens like Salmonella Typhimurium (S.Tm) can overcome this obstacle. Using live microscopy, we monitored S.Tm interactions with native murine gut explants and studied how mucus affects the infection. A dense inner mucus layer covers the distal...

journal_title：Cell reports

authors： Furter M,Sellin ME,Hansson GC,Hardt WD

更新日期：2019-05-28 00:00:00

abstract：:Inhibition of RNA polymerase I (Pol I) is a promising strategy for modern cancer therapy. BMH-21 is a first-in-class small molecule that inhibits Pol I transcription and induces degradation of the enzyme, but how this exceptional response is enforced is not known. Here, we define key elements requisite for the respons...

journal_title：Cell reports

authors： Wei T,Najmi SM,Liu H,Peltonen K,Kucerova A,Schneider DA,Laiho M

更新日期：2018-04-10 00:00:00

abstract：:Despite the significance for fetal nourishment in mammals, mechanisms of umbilical cord vascular growth remain poorly understood. Here, the secreted metalloprotease ADAMTS9 is shown to be necessary for murine umbilical cord vascular development. Restricting it to the cell surface using a gene trap allele, Adamts9(Gt),...

journal_title：Cell reports

authors： Nandadasa S,Nelson CM,Apte SS

更新日期：2015-06-16 00:00:00