Abstract：
:Folates are cofactors for biosynthetic enzymes in all eukaryotic and prokaryotic cells. Animals cannot synthesize folate and must acquire it from their diet or microbiota. Previously, we showed that inhibiting E. coli folate synthesis increases C. elegans lifespan. Here, we show that restriction or supplementation of C. elegans folate does not influence lifespan. Thus, folate is required in E. coli to shorten worm lifespan. Bacterial proliferation in the intestine has been proposed as a mechanism for the life-shortening influence of E. coli. However, we found no correlation between C. elegans survival and bacterial growth in a screen of 1,000+ E. coli deletion mutants. Nine mutants increased worm lifespan robustly, suggesting specific gene regulation is required for the life-shortening activity of E. coli. Disrupting the biosynthetic folate cycle did not increase lifespan. Thus, folate acts through a growth-independent route in E. coli to accelerate animal aging.
journal_name
Cell Repjournal_title
Cell reportsauthors
Virk B,Jia J,Maynard CA,Raimundo A,Lefebvre J,Richards SA,Chetina N,Liang Y,Helliwell N,Cipinska M,Weinkove Ddoi
10.1016/j.celrep.2016.01.051subject
Has Abstractpub_date
2016-02-23 00:00:00pages
1611-1620issue
7issn
2211-1247pii
S2211-1247(16)30029-8journal_volume
14pub_type
杂志文章相关文献
Cell Reports文献大全abstract：:Quiescence is a fundamental property of adult stem cells. Recent evidence indicates that quiescence is not a default state but requires active signaling that prevents accidental or untimely activation of stem cells. The calcitonin receptor (CalcR) is critical for sustaining quiescence in muscle satellite (stem) cells ...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2019.10.057
更新日期：2019-11-19 00:00:00
abstract：:G-protein-coupled receptors (GPCRs) constitute the largest superfamily of cell-surface signaling proteins. However, mechanisms underlying their surface targeting and sorting are poorly understood. Here, we screen the Rab family of small GTPases in the surface transport of multiple GPCRs. We find that manipulation of R...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2017.10.011
更新日期：2017-10-24 00:00:00
abstract：:The ultimate goal of protein design is to introduce new biological activity. We propose a computational approach for designing functional antibodies by focusing on functional epitopes, integrating large-scale statistical analysis with multiple structural models. Machine learning is used to analyze these models and pre...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2018.10.081
更新日期：2018-11-20 00:00:00
abstract：:Inflammasome activation is associated with numerous diseases. However, in vivo detection of the activated inflammasome complex has been limited by a dearth of tools. We have developed transgenic mice that ectopically express the fluorescent adaptor protein, apoptosis-associated speck-like protein containing a caspase ...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2016.06.011
更新日期：2016-07-12 00:00:00
abstract：:Maintaining organelle function in the face of stress is known to involve organelle-specific retrograde signaling. Using Caenorhabditis elegans, we present evidence of the existence of such retrograde signaling for peroxisomes, which we define as the peroxisomal retrograde signaling (PRS). Specifically, we show that pe...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2020.108653
更新日期：2021-01-19 00:00:00
abstract：:Oxytocin is a hormone with various actions. Oxytocin-containing parvocellular neurons project to the brainstem and spinal cord. Oxytocin release from these neurons suppresses nociception of inflammatory pain, the molecular mechanism of which remains unclear. Here, we report that the noxious stimulus receptor TRPV1 is ...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2017.10.063
更新日期：2017-11-07 00:00:00
abstract：:Chromosomes with multiple DNA replication origins are a hallmark of Eukaryotes and some Archaea. All eukaryal nuclear replication origins are defined by the origin recognition complex (ORC) that recruits the replicative helicase MCM(2-7) via Cdc6 and Cdt1. We find that the three origins in the single chromosome of the...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2013.01.002
更新日期：2013-02-21 00:00:00
abstract：:The NLRP3 inflammasome, a critical component of the innate immune system, induces caspase-1 activation and interleukin (IL)-1β maturation in response to microbial infection and cellular damage. However, aberrant activation of the NLRP3 inflammasome contributes to the pathogenesis of several inflammatory disorders, inc...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2020.108405
更新日期：2020-11-17 00:00:00
abstract：:Here, we propose an approach to identify active metabolic pathways by integrating gene essentiality analysis and protein abundance. We use two bacterial species (Mycoplasma pneumoniae and Mycoplasma agalactiae) that share a high gene content similarity yet show significant metabolic differences. First, we build detail...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2020.107722
更新日期：2020-06-02 00:00:00
abstract：:Sustained canonical Wnt signaling requires the inhibition of glycogen synthase kinase 3 (GSK3) activity by sequestration of GSK3 inside multivesicular endosomes (MVEs). Here, we show that Wnt signaling is increased by the lysosomal inhibitor chloroquine, which causes accumulation of MVEs. A similar MVE expansion and i...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2012.09.026
更新日期：2012-11-29 00:00:00
abstract：:Transcription-factor-induced reprogramming of somatic cells to pluripotency is a very inefficient process, probably due to the existence of important epigenetic barriers that are imposed during differentiation and that contribute to preserving cell identity. In an effort to decipher the molecular nature of these barri...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2013.02.029
更新日期：2013-04-25 00:00:00
abstract：:Recurrent epidemics of drug-resistant Staphylococcus aureus illustrate the rapid lapse of antibiotic efficacy following clinical implementation. Over the last decade, community-associated methicillin-resistant S. aureus (MRSA) has emerged as a dominant cause of infections, and this problem is amplified by the hyper-vi...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2019.03.018
更新日期：2019-04-02 00:00:00
abstract：:The cellular responses induced by mitochondrial dysfunction remain elusive. Intrigued by the lack of almost any glomerular phenotype in patients with profound renal ischemia, we comprehensively investigated the primary sources of energy of glomerular podocytes. Combining functional measurements of oxygen consumption r...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2019.04.012
更新日期：2019-04-30 00:00:00
abstract：:Long-lasting forms of synaptic plasticity such as synaptic scaling are critically dependent on transcription. Activity-dependent transcriptional dynamics in neurons, however, remain incompletely characterized because most previous efforts relied on measurement of steady-state mRNAs. Here, we use nascent RNA sequencing...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2020.108002
更新日期：2020-08-11 00:00:00
abstract：:G9a is a lysine methyltransferase that regulates epigenetic modifications, transcription, and genome organization. However, whether these properties are dependent on one another or represent distinct functions of G9a remains unclear. In this study, we observe widespread DNA methylation loss in G9a depleted and catalyt...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2020.108315
更新日期：2020-10-27 00:00:00
abstract：:Insulin stimulates glucose uptake through the membrane translocation of GLUT4 and GLUT1. Peroxisome proliferator-activated receptor γ (PPARγ) enhances insulin sensitivity. Here, we demonstrate that insulin stimulates GLUT4 and GLUT1 translocation, and glucose uptake, by activating the signaling pathway involving nicot...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2012.10.018
更新日期：2012-12-27 00:00:00
abstract：:Complex architectural rearrangements are associated to the control of the HoxD genes in different cell types; yet, how they are implemented in single cells remains unknown. By use of polymer models, we dissect the locus 3D structure at the single DNA molecule level in mouse embryonic stem and cortical neuronal cells, ...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2019.07.013
更新日期：2019-08-06 00:00:00
abstract：:Serine ADP-ribosylation (Ser-ADPr) is a recently discovered protein modification that is catalyzed by PARP1 and PARP2 when in complex with the eponymous histone PARylation factor 1 (HPF1). In addition to numerous other targets, core histone tails are primary acceptors of Ser-ADPr in the DNA damage response. Here, we s...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2018.08.092
更新日期：2018-09-25 00:00:00
abstract：:During bacterial sepsis, proinflammatory cytokines contribute to multiorgan failure and death in a process regulated in part by cytolytic cell granzymes. When challenged with a sublethal dose of the identified mouse pathogen Brucella microti, wild-type (WT) and granzyme A (gzmA)(-/-) mice eliminate the organism from l...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2014.06.012
更新日期：2014-07-24 00:00:00
abstract：:Vesicular glutamate transporters (VGLUTs) fill synaptic vesicles with glutamate and are thus essential for glutamatergic neurotransmission. However, VGLUTs were originally discovered as members of a transporter subfamily specific for inorganic phosphate (Pi). It is still unclear how VGLUTs accommodate glutamate transp...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2018.03.055
更新日期：2018-04-10 00:00:00
abstract：:Hypertrophic cardiomyopathy (HCM) is a well-established risk factor for cardiovascular mortality worldwide. Although hypertrophy is traditionally regarded as an adaptive response to physiological or pathological stress, prolonged hypertrophy can lead to heart failure. Here we demonstrate that Prdm16 is dispensable for...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2020.108288
更新日期：2020-10-20 00:00:00
abstract：:Loss of metabolic homeostasis is a hallmark of aging and is commonly characterized by the deregulation of adaptive signaling interactions that coordinate energy metabolism with dietary changes. The mechanisms driving age-related changes in these adaptive responses remain unclear. Here, we characterize the deregulation...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2013.08.004
更新日期：2013-09-26 00:00:00
abstract：:The phosphatidylinositol 3-kinase (PI3K) signaling cascade downstream of the B cell receptor (BCR) signalosome is essential for B cell maturation. Proper signaling strength is maintained through the PI3K negative regulator phosphatase and tensin homolog (PTEN). Although a role for microRNA (miRNA)-dependent control of...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2020.108436
更新日期：2020-12-01 00:00:00
abstract：:Trimethylation of histone H3 at lysine-4 (H3K4me3) is associated with eukaryotic gene promoters and poises their transcriptional activation during development. To examine the in vivo function of H3K4me3 in the absence of DNA replication, we deleted CXXC finger protein 1 (CFP1), the DNA-binding subunit of the SETD1 his...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2017.07.011
更新日期：2017-08-01 00:00:00
abstract：:Chronic exposure to nicotine upregulates nicotinic acetylcholine receptors (nAChRs), and such upregulation is critical for the development of nicotine dependence in humans and animal models. However, how nicotine upregulates nAChRs is not well understood. Here, we identify a key role for microRNA in regulating nicotin...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2017.10.043
更新日期：2017-11-07 00:00:00
abstract：:Hippocampal sharp-wave ripples (SPW-Rs) support consolidation of recently acquired episodic memories and planning future actions by generating ordered neuronal sequences of previous or future experiences. SPW-Rs are characterized by several spectral components: a slow (5-15 Hz) sharp-wave, a high-frequency "ripple" os...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2018.10.066
更新日期：2018-11-13 00:00:00
abstract：:The endothelial monolayer forms a barrier between the lumen of blood vessels and the underlying tissues. Stable VE-cadherin-based adherens junctions are essential for maintaining this barrier, whereas their remodeling is required for angiogenesis in health and disease. Here, we position the ERAD-associated ubiquitin l...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2020.107944
更新日期：2020-08-04 00:00:00
abstract：:Plasmodium parasites infect the liver and replicate inside hepatocytes before they invade erythrocytes and trigger clinical malaria. Analysis of host signaling pathways affected by liver-stage infection could provide critical insights into host-pathogen interactions and reveal targets for intervention. Using protein l...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2013.02.010
更新日期：2013-03-28 00:00:00
abstract：:Antimetabolites that affect nucleotide metabolism are frontline chemotherapy agents in several cancers and often successfully target one carbon metabolism. However, the precise mechanisms and resulting determinants of their therapeutic value are unknown. We show that 5-fluorouracil (5-FU), a commonly used antimetaboli...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2016.05.035
更新日期：2016-06-14 00:00:00
abstract：:How artificial environmental cues are biologically integrated and transgenerationally inherited is still poorly understood. Here, we investigate the mechanisms of inheritance of reproductive outcomes elicited by the model environmental chemical Bisphenol A in C. elegans. We show that Bisphenol A (BPA) exposure causes ...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2018.04.078
更新日期：2018-05-22 00:00:00
