Origin of Gamma Frequency Power during Hippocampal Sharp-Wave Ripples.

abstract：:Nucleoplasmin (Npm) is an abundant histone chaperone in vertebrate oocytes and embryos. During embryogenesis, regulation of Npm histone binding is critical for its function in storing and releasing maternal histones to establish and maintain the zygotic epigenome. Here, we demonstrate that Xenopus laevis Npm post-tran...

journal_title：Cell reports

authors： Onikubo T,Nicklay JJ,Xing L,Warren C,Anson B,Wang WL,Burgos ES,Ruff SE,Shabanowitz J,Cheng RH,Hunt DF,Shechter D

更新日期：2015-03-17 00:00:00

abstract：:Histone H3 lysine 79 (H3K79) methylation is enriched on actively transcribed genes, and its misregulation is a hallmark of leukemia. Methylation of H3K79, which resides on the structured disk face of the nucleosome, is mediated by the Dot1L methyltransferase. Dot1L activity is part of a trans-histone crosstalk pathway...

journal_title：Cell reports

authors： Anderson CJ,Baird MR,Hsu A,Barbour EH,Koyama Y,Borgnia MJ,McGinty RK

更新日期：2019-02-12 00:00:00

abstract：:Neurons exhibit dynamic structural changes in response to extracellular stimuli. Microtubules (MTs) provide rapid and dramatic cytoskeletal changes within the structural framework. However, the molecular mechanisms and signaling networks underlying MT dynamics remain unknown. Here, we have applied a comprehensive and ...

journal_title：Cell reports

authors： Ogawa T,Hirokawa N

更新日期：2015-09-22 00:00:00

abstract：:Experimental large-scale screens for drug repositioning are limited by restriction to in vitro conditions and lack of applicability to real human conditions. Here, we developed an in silico screen in human in vivo conditions using a reference of single gene mutations' non-tissue-specific "core transcriptome signatures...

journal_title：Cell reports

authors： Xu C,Ai D,Shi D,Suo S,Chen X,Yan Y,Cao Y,Zhang R,Sun N,Chen W,McDermott J,Zhang S,Zeng Y,Han JJ

更新日期：2018-10-09 00:00:00

abstract：:Multidonor antibodies are of interest for vaccine design because they can in principle be elicited in the general population by a common set of immunogens. For influenza, multidonor antibodies have been observed against the hemagglutinin (HA) stem, but not the immunodominant HA head. Here, we identify and characterize...

journal_title：Cell reports

authors： Cheung CS,Fruehwirth A,Paparoditis PCG,Shen CH,Foglierini M,Joyce MG,Leung K,Piccoli L,Rawi R,Silacci-Fregni C,Tsybovsky Y,Verardi R,Wang L,Wang S,Yang ES,Zhang B,Zhang Y,Chuang GY,Corti D,Mascola JR,Shapiro L,K

更新日期：2020-09-01 00:00:00

abstract：:Mucus separates gut-luminal microbes from the tissue. It is unclear how pathogens like Salmonella Typhimurium (S.Tm) can overcome this obstacle. Using live microscopy, we monitored S.Tm interactions with native murine gut explants and studied how mucus affects the infection. A dense inner mucus layer covers the distal...

journal_title：Cell reports

authors： Furter M,Sellin ME,Hansson GC,Hardt WD

更新日期：2019-05-28 00:00:00

abstract：:The development of an embryo requires precise spatiotemporal regulation of cellular processes. During Drosophila gastrulation, a precise temporal pattern of cell division is encoded through transcriptional regulation of cdc25(string) in 25 distinct mitotic domains. Using a genetic screen, we demonstrate that the same ...

journal_title：Cell reports

authors： Momen-Roknabadi A,Di Talia S,Wieschaus E

更新日期：2016-09-13 00:00:00

abstract：:Clinical transplantation of tissue fragments, including islets, faces a critical challenge because of a lack of effective strategies that ensure efficient engraftment through the timely integration of vascular networks. We recently developed a complex organoid engineering method by "self-condensation" culture based on...

journal_title：Cell reports

authors： Takahashi Y,Sekine K,Kin T,Takebe T,Taniguchi H

更新日期：2018-05-08 00:00:00

abstract：:Fast purinergic signaling is mediated by ATP and ATP-gated ionotropic P2X receptors (P2XRs), and it is implicated in pain-related behaviors. The properties exhibited by P2XRs vary between those expressed in heterologous cells and in vivo. Several modulators of ligand-gated ion channels have recently been identified, s...

journal_title：Cell reports

authors： Salm EJ,Dunn PJ,Shan L,Yamasaki M,Malewicz NM,Miyazaki T,Park J,Sumioka A,Hamer RRL,He WW,Morimoto-Tomita M,LaMotte RH,Tomita S

更新日期：2020-06-02 00:00:00

abstract：:CELF6 is a CELF-RNA-binding protein, and thus part of a protein family with roles in human disease; however, its mRNA targets in the brain are largely unknown. Using cross-linking immunoprecipitation and sequencing (CLIP-seq), we define its CNS targets, which are enriched for 3' UTRs in synaptic protein-coding genes. ...

journal_title：Cell reports

authors： Rieger MA,King DM,Crosby H,Liu Y,Cohen BA,Dougherty JD

更新日期：2020-12-22 00:00:00

abstract：:The role of CTCF in stabilizing long-range interactions between chromatin sites essential for maintaining nuclear architecture is well established. Most of these interactions involve recruitment of the cohesin complex to chromatin via CTCF. We find that CTCF also interacts with the centromeric protein CENP-E both in v...

journal_title：Cell reports

authors： Xiao T,Wongtrakoongate P,Trainor C,Felsenfeld G

更新日期：2015-09-08 00:00:00

abstract：:The mechanisms by which p53 suppresses tumor growth remain ill defined. In this issue of Cell Reports, Timofeev et al. (2013) and Valente et al. (2013) reveal context-dependent contributions of p53-dependent apoptosis to its tumor-suppressive function. ...

journal_title：Cell reports

authors： Mellert H,Espinosa JM

更新日期：2013-05-30 00:00:00

abstract：:Epiblast cells in the early post-implantation stage mammalian embryo undergo a transition described as lineage priming before cell fate allocation, but signaling pathways acting upstream remain ill defined. Genetic studies demonstrate that Smad2/3 double-mutant mouse embryos die shortly after implantation. To learn mo...

journal_title：Cell reports

authors： Senft AD,Costello I,King HW,Mould AW,Bikoff EK,Robertson EJ

更新日期：2018-08-21 00:00:00

abstract：:In spinal muscular atrophy, a neurodegenerative disease caused by ubiquitous deficiency in the survival motor neuron (SMN) protein, sensory-motor synaptic dysfunction and increased excitability precede motor neuron (MN) loss. Whether central synaptic dysfunction and MN hyperexcitability are cell-autonomous events or t...

journal_title：Cell reports

authors： Simon CM,Janas AM,Lotti F,Tapia JC,Pellizzoni L,Mentis GZ

更新日期：2016-08-02 00:00:00

abstract：:Transcription factors and chromatin-remodeling complexes are key determinants of embryonic stem cell (ESC) identity. Here, we demonstrate that BRD4, a member of the bromodomain and extraterminal domain (BET) family of epigenetic readers, regulates the self-renewal ability and pluripotency of ESCs. BRD4 inhibition resu...

journal_title：Cell reports

authors： Di Micco R,Fontanals-Cirera B,Low V,Ntziachristos P,Yuen SK,Lovell CD,Dolgalev I,Yonekubo Y,Zhang G,Rusinova E,Gerona-Navarro G,Cañamero M,Ohlmeyer M,Aifantis I,Zhou MM,Tsirigos A,Hernando E

更新日期：2014-10-09 00:00:00

abstract：:Selecting a suitable site to deposit their eggs is an important reproductive need of Drosophila females. Although their choosiness toward egg-laying sites is well documented, the specific neural mechanism that activates females' search for attractive egg-laying sites is not known. Here, we show that distention and con...

journal_title：Cell reports

authors： Gou B,Liu Y,Guntur AR,Stern U,Yang CH

更新日期：2014-10-23 00:00:00

abstract：:The role of CD4+ T cells in the ischemic tissues of T2D patients remains unclear. Here, we report that T2D patients' vascular density was negatively correlated with the number of infiltrating CD4+ T cells after ischemic injury. Th1 was the predominant subset, and Th1-derived IFN-γ and TNF-α directly impaired human ang...

journal_title：Cell reports

authors： Leung OM,Li J,Li X,Chan VW,Yang KY,Ku M,Ji L,Sun H,Waldmann H,Tian XY,Huang Y,Lau J,Zhou B,Lui KO

更新日期：2018-08-07 00:00:00

abstract：:In higher vertebrates, cephalic neural crest cells (NCCs) form craniofacial skeleton by differentiating into chondrocytes and osteoblasts. A subpopulation of cephalic NCCs, cardiac NCCs (CNCCs), migrates to the heart. However, CNCCs mostly do not yield skeletogenic derivatives, and the molecular mechanisms of this fat...

journal_title：Cell reports

authors： Arai HN,Sato F,Yamamoto T,Woltjen K,Kiyonari H,Yoshimoto Y,Shukunami C,Akiyama H,Kist R,Sehara-Fujisawa A

更新日期：2019-10-15 00:00:00

abstract：:Bromodomain and extra-terminal domain (BET) family inhibitors offer an approach to treating hematological malignancies. We used precision nuclear run-on transcription sequencing (PRO-seq) to create high-resolution maps of active RNA polymerases across the genome in t(8;21) acute myeloid leukemia (AML), as these polyme...

journal_title：Cell reports

authors： Zhao Y,Liu Q,Acharya P,Stengel KR,Sheng Q,Zhou X,Kwak H,Fischer MA,Bradner JE,Strickland SA,Mohan SR,Savona MR,Venters BJ,Zhou MM,Lis JT,Hiebert SW

更新日期：2016-08-16 00:00:00

abstract：:RNAi screens have implicated hundreds of host proteins as HIV-1 dependency factors (HDFs). While informative, these early studies overlap poorly due to false positives and false negatives. To ameliorate these issues, we combined information from the existing HDF screens together with new screens performed with multipl...

journal_title：Cell reports

authors： Zhu J,Davoli T,Perriera JM,Chin CR,Gaiha GD,John SP,Sigiollot FD,Gao G,Xu Q,Qu H,Pertel T,Sims JS,Smith JA,Baker RE,Maranda L,Ng A,Elledge SJ,Brass AL

更新日期：2014-10-23 00:00:00

abstract：:Transcription-factor-induced reprogramming of somatic cells to pluripotency is a very inefficient process, probably due to the existence of important epigenetic barriers that are imposed during differentiation and that contribute to preserving cell identity. In an effort to decipher the molecular nature of these barri...

journal_title：Cell reports

authors： Barrero MJ,Sese B,Kuebler B,Bilic J,Boue S,Martí M,Izpisua Belmonte JC

更新日期：2013-04-25 00:00:00

abstract：:Cell growth is coupled to cell-cycle progression in mitotically proliferating mammalian cells, but the underlying molecular mechanisms are not well understood. CyclinD-Cdk4/6 is known to phosphorylate RB to promote S-phase entry, but recent work suggests they have additional functions. We show here that CyclinD-Cdk4/6...

journal_title：Cell reports

authors： Romero-Pozuelo J,Figlia G,Kaya O,Martin-Villalba A,Teleman AA

更新日期：2020-04-14 00:00:00

abstract：:To ensure a successful infection, herpesviruses have developed elegant strategies to counterbalance the host anti-viral responses. Sterile alpha motif and HD domain 1 (SAMHD1) was recently identified as an intrinsic restriction factor for a variety of viruses. Aside from HIV-2 and the related simian immunodeficiency v...

journal_title：Cell reports

authors： Zhang K,Lv DW,Li R

更新日期：2019-07-09 00:00:00

abstract：:Granule cells (GCs) of the cerebellar input layer express high-affinity δ GABAA subunit-containing GABAA receptors (δGABAARs) that respond to ambient GABA levels and context-dependent neuromodulators like steroids. We find that GC-specific deletion of δGABAA (cerebellar [cb] δ knockout [KO]) decreases tonic inhibition...

journal_title：Cell reports

authors： Rudolph S,Guo C,Pashkovski SL,Osorno T,Gillis WF,Krauss JM,Nyitrai H,Flaquer I,El-Rifai M,Datta SR,Regehr WG

更新日期：2020-11-03 00:00:00

abstract：:Synapses are fundamental to the normal function of the nervous system. Glia play a pivotal role in regulating synaptic formation. However, how presynaptic neurons assemble synaptic structure in response to the glial signals remains largely unexplored. To address this question, we use cima-1 mutant C. elegans as an in ...

journal_title：Cell reports

authors： Dong X,Jin S,Shao Z

更新日期：2020-02-25 00:00:00

abstract：:Calcium signaling has long been associated with key events of immunity, including chemotaxis, phagocytosis, and activation. However, imaging and manipulation of calcium flux in motile immune cells in live animals remain challenging. Using light-sheet microscopy for in vivo calcium imaging in zebrafish, we observe char...

journal_title：Cell reports

authors： Beerman RW,Matty MA,Au GG,Looger LL,Choudhury KR,Keller PJ,Tobin DM

更新日期：2015-12-15 00:00:00

abstract：:G-protein-coupled receptors (GPCRs) constitute the largest superfamily of cell-surface signaling proteins. However, mechanisms underlying their surface targeting and sorting are poorly understood. Here, we screen the Rab family of small GTPases in the surface transport of multiple GPCRs. We find that manipulation of R...

journal_title：Cell reports

authors： Li C,Wei Z,Fan Y,Huang W,Su Y,Li H,Dong Z,Fukuda M,Khater M,Wu G

更新日期：2017-10-24 00:00:00

abstract：:Residual cell-intrinsic innate immunity in cancer cells hampers infection with oncolytic viruses. Translational control of mRNA is an important feature of innate immunity, yet the identity of translationally regulated mRNAs functioning in host defense remains ill-defined. We report the translatomes of resistant murine...

journal_title：Cell reports

authors： Hoang HD,Graber TE,Jia JJ,Vaidya N,Gilchrist VH,Xiang X,Li W,Cowan KN,Gkogkas CG,Jaramillo M,Jafarnejad SM,Alain T

更新日期：2019-12-17 00:00:00

abstract：:While interphase mitochondria associate with microtubules, mitotic mitochondria dissociate from spindle microtubules and localize in the cell periphery. Here, we show that this redistribution is not mediated by mitochondrial active transport or tethering to the cytoskeleton. Instead, kinesin and dynein, which link mit...

journal_title：Cell reports

authors： Chung JY,Steen JA,Schwarz TL

更新日期：2016-08-23 00:00:00

abstract：:Microbes have shown a remarkable ability in evading the killing actions of antimicrobial agents, such that treatment of bacterial infections represents once more an urgent global challenge. Understanding the initial bacterial response to antimicrobials may reveal intrinsic tolerance mechanisms to antibiotics and sugge...

journal_title：Cell reports

authors： Zampieri M,Zimmermann M,Claassen M,Sauer U

更新日期：2017-05-09 00:00:00