Abstract：
:The INO80 complex (INO80-C) is an evolutionarily conserved nucleosome remodeler that acts in transcription, replication, and genome stability. It is required for resistance against genotoxic agents and is involved in the repair of DNA double-strand breaks (DSBs) by homologous recombination (HR). However, the causes of the HR defect in INO80-C mutant cells are controversial. Here, we unite previous findings using a system to study HR with high spatial resolution in budding yeast. We find that INO80-C has at least two distinct functions during HR-DNA end resection and presynaptic filament formation. Importantly, the second function is linked to the histone variant H2A.Z. In the absence of H2A.Z, presynaptic filament formation and HR are restored in INO80-C-deficient mutants, suggesting that presynaptic filament formation is the crucial INO80-C function during HR.
journal_name
Cell Repjournal_title
Cell reportsauthors
Lademann CA,Renkawitz J,Pfander B,Jentsch Sdoi
10.1016/j.celrep.2017.04.051subject
Has Abstractpub_date
2017-05-16 00:00:00pages
1294-1303issue
7issn
2211-1247pii
S2211-1247(17)30545-4journal_volume
19pub_type
杂志文章相关文献
Cell Reports文献大全abstract：:We examined the effect of Bone Morphogenetic Protein 4 (BMP4) on energy expenditure in adult mature mice by targeting the liver with adeno-associated viral (AAV) BMP4 vectors to increase circulating levels. We verified the direct effect of BMP4 in inducing a brown oxidative phenotype in differentiating preadipocytes i...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2017.07.020
更新日期：2017-08-01 00:00:00
abstract：:Cytotoxic CD8(+) T lymphocytes play a critical role in the host response to infection by viruses. The ability to secrete cytotoxic chemicals and cytokines is considered pivotal for eliminating virus. Of equal importance is how effector CD8(+) T cells home to virus-infected tissues. L-selectin has not been considered i...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2015.12.090
更新日期：2016-02-02 00:00:00
abstract：:Yes-associated protein (YAP) is regulated by mechanical cues via the interaction of the Hippo pathway with cytoskeleton. Previous studies showed that YAP plays a role in regulating the actomyosin network by suppressing Rho GTPase in medaka fish. Here, we identify Rho GTPase activating protein 29 (ARHGAP29) as a transc...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2017.04.075
更新日期：2017-05-23 00:00:00
abstract：:Loss of NF-κB signaling causes immunodeficiency, whereas inhibition of NF-κB can be efficacious in treating chronic inflammatory disease. Inflammatory NF-κB signaling must therefore be tightly regulated, and although many mechanisms to downregulate NF-κB have been elucidated, there have only been limited studies demon...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2015.06.050
更新日期：2015-07-28 00:00:00
abstract：:Although our understanding of centromere maintenance, marked by the histone H3 variant CenH3(CENP-A) in most eukaryotes, has progressed, the mechanism underlying the de novo formation of centromeres remains unclear. We used a synthetic system to dissect how CenH3(CENP-A) contributes to the accumulation of CENP-C and C...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2015.03.013
更新日期：2015-04-07 00:00:00
abstract：:Microglia are resident immune cells of the CNS that are activated by infection, neuronal injury, and inflammation. Here, we utilize flow cytometry and deep RNA sequencing of acutely isolated spinal cord microglia to define their activation in vivo. Analysis of resting microglia identified 29 genes that distinguish mic...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2013.06.018
更新日期：2013-07-25 00:00:00
abstract：:Centromeric nucleosomes are critical for chromosome attachment to the mitotic spindle. In this issue of Cell Reports, Diaz-Ingelmo et al. (2015) propose that the yeast centromeric nucleosome is stabilized by a positively supercoiled loop formed by the sequence-specific CBF3 complex. ...
journal_title：Cell reports
pub_type： 评论,杂志文章
doi：10.1016/j.celrep.2015.10.007
更新日期：2015-10-27 00:00:00
abstract：:Redox-mediated posttranslational modifications represent a molecular switch that controls major mechanisms of cell function. Nitric oxide (NO) can mediate redox reactions via S-nitrosylation, representing transfer of an NO group to a critical protein thiol. NO is known to modulate neurogenesis and neuronal survival in...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2014.06.005
更新日期：2014-07-10 00:00:00
abstract：:It is currently assumed that 3D chromosomal organization plays a central role in transcriptional control. However, depletion of cohesin and CTCF affects the steady-state levels of only a minority of transcripts. Here, we use high-resolution Capture Hi-C to interrogate the dynamics of chromosomal contacts of all annota...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2020.107929
更新日期：2020-07-21 00:00:00
abstract：:Melanomas accumulate a high burden of mutations that could potentially generate neoantigens, yet somehow suppress the immune response to facilitate continued growth. In this study, we identify a subset of human melanomas that have loss-of-function mutations in ATR, a kinase that recognizes and repairs UV-induced DNA d...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2017.02.040
更新日期：2017-03-07 00:00:00
abstract：:Unconventional secretion of exosome vesicles from multivesicular endosomes (MVEs) occurs across a broad set of systems and is reported to be upregulated in cancer, where it promotes aggressive behavior. However, regulatory control of exosome secretion is poorly understood. Using cancer cells, we identified specialized...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2013.10.050
更新日期：2013-12-12 00:00:00
abstract：:During termination of translation, the nascent peptide is first released from the ribosome, which must be subsequently disassembled into subunits in a process known as ribosome recycling. In bacteria, termination and recycling are mediated by the translation factors RF, RRF, EF-G, and IF3, but their precise roles have...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2017.06.028
更新日期：2017-07-05 00:00:00
abstract：:Glucose-dependent insulinotropic polypeptide (GIP) is an incretin hormone involved in nutrient homeostasis. GIP receptor (GIPR) is constitutively internalized and returned to the plasma membrane, atypical behavior for a G-protein-coupled receptor (GPCR). GIP promotes GIPR downregulation from the plasma membrane by inh...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2016.11.050
更新日期：2016-12-13 00:00:00
abstract：:We have identified and validated a spaceflight-associated microRNA (miRNA) signature that is shared by rodents and humans in response to simulated, short-duration and long-duration spaceflight. Previous studies have identified miRNAs that regulate rodent responses to spaceflight in low-Earth orbit, and we have confirm...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2020.108448
更新日期：2020-12-08 00:00:00
abstract：:The small GTPase RhoA is involved in a variety of fundamental processes in normal tissue. Spatiotemporal control of RhoA is thought to govern mechanosensing, growth, and motility of cells, while its deregulation is associated with disease development. Here, we describe the generation of a RhoA-fluorescence resonance e...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2017.09.022
更新日期：2017-10-03 00:00:00
abstract：:During chronic infection, the inflammatory cytokine interferon gamma (IFNγ) damages hematopoietic stem cells (HSCs) by disrupting quiescence and promoting excessive terminal differentiation. However, the mechanism by which IFNγ hinders HSC quiescence remains undefined. Using intravital 3-dimensional microscopy, we fin...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2020.108530
更新日期：2020-12-22 00:00:00
abstract：:Kappa opioid receptors (KORs) are involved in a variety of aversive behavioral states, including anxiety. To date, a circuit-based mechanism for KOR-driven anxiety has not been described. Here, we show that activation of KORs inhibits glutamate release from basolateral amygdala (BLA) inputs to the bed nucleus of the s...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2016.02.069
更新日期：2016-03-29 00:00:00
abstract：:We recently reported an autosomal dominant form of renal Fanconi syndrome caused by a missense mutation in the third codon of the peroxisomal protein EHHADH. The mutation mistargets EHHADH to mitochondria, thereby impairing mitochondrial energy production and, consequently, reabsorption of electrolytes and low-molecul...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2016.04.037
更新日期：2016-05-17 00:00:00
abstract：:Recycling of neurotransmitters is essential for sustained neuronal signaling, yet recycling pathways for various transmitters, including histamine, remain poorly understood. In the first visual ganglion (lamina) of Drosophila, photoreceptor-released histamine is taken up into perisynaptic glia, converted to carcinine,...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2016.02.009
更新日期：2016-03-08 00:00:00
abstract：:Inflammatory bowel disease (IBD) is prevalent, but the mechanisms underlying disease development remain elusive. We identify a role for the E3 ubiquitin ligase RNF5 in IBD. Intestinal epithelial cells (IECs) express a high level of RNF5, while the colon of Rnf5-/- mice exhibits activated dendritic cells and intrinsic ...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2018.08.057
更新日期：2018-09-18 00:00:00
abstract：:How artificial environmental cues are biologically integrated and transgenerationally inherited is still poorly understood. Here, we investigate the mechanisms of inheritance of reproductive outcomes elicited by the model environmental chemical Bisphenol A in C. elegans. We show that Bisphenol A (BPA) exposure causes ...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2018.04.078
更新日期：2018-05-22 00:00:00
abstract：:Cell size control emerges from a regulated balance between the rates of cell growth and division. In bacteria, simple quantitative laws connect cellular growth rate to ribosome abundance. However, it remains poorly understood how translation regulates bacterial cell size and shape under growth perturbations. Here, we ...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2020.108183
更新日期：2020-09-22 00:00:00
abstract：:Innate immunity is central to the pathophysiology of neurodegenerative disorders, but it remains unclear why immunity is altered in the disease state and whether changes in immunity are a cause or a consequence of neuronal dysfunction. Here, we identify a molecular pathway that links innate immunity to age-dependent l...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2018.12.025
更新日期：2019-01-02 00:00:00
abstract：:Oxytocin and its receptor (Oxtr) play a crucial role in the postnatal transition of neuronal GABA neurotransmission from excitatory to inhibitory, a developmental process known as the GABA switch. Using hippocampal neurons from Oxtr-null mice, we show that (1) Oxtr is necessary for the correct timing of the GABA switc...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2016.03.013
更新日期：2016-04-05 00:00:00
abstract：:Mitochondria shape is controlled by membrane fusion and fission mediated by mitofusins, Opa1, and Drp1, whereas mitochondrial motility relies on microtubule motors. These processes govern mitochondria subcellular distribution, whose defects are emphasized in neurons because of their polarized structure. We have studie...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2018.04.017
更新日期：2018-05-08 00:00:00
abstract：:Activation of postsynaptic metabotropic glutamate receptors (mGluRs) modulates neuronal excitability and synaptic plasticity, while deregulation of mGluR signaling has been implicated in neurodevelopmental disorders. Overstimulation of mGluRs is restricted by the rapid endocytosis of receptors after activation. Howeve...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2019.08.102
更新日期：2019-10-08 00:00:00
abstract：:One puzzling observation in patients affected with Hutchinson-Gilford progeria syndrome (HGPS), who overall exhibit systemic and dramatic premature aging, is the absence of any conspicuous cognitive impairment. Recent studies based on induced pluripotent stem cells derived from HGPS patient cells have revealed a lack ...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2012.05.015
更新日期：2012-07-26 00:00:00
abstract：:MicroRNAs (miRNAs) regulate diverse biological processes by repressing mRNAs, but their modest effects on direct targets, together with their participation in larger regulatory networks, make it challenging to delineate miRNA-mediated effects. Here, we describe an approach to characterizing miRNA-regulatory networks b...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2015.12.031
更新日期：2016-01-12 00:00:00
abstract：:The metabolic enzyme phosphoglycerate mutase 1 (PGAM1) is overexpressed in several types of cancer, suggesting an additional function beyond its established role in the glycolytic pathway. We here report that PGAM1 is overexpressed in gliomas where it increases the efficiency of the DNA damage response (DDR) pathway b...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2020.03.082
更新日期：2020-04-14 00:00:00
abstract：:Manipulation of the master regulator of energy homeostasis AMP-activated protein kinase (AMPK) activity is a strategy used by many intracellular pathogens for successful replication. Infection by most pathogens leads to an activation of host AMPK activity due to the energetic demands placed on the infected cell. Here,...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2016.08.001
更新日期：2016-09-06 00:00:00
