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ATR Mutations Promote the Growth of Melanoma Tumors by Modulating the Immune Microenvironment.

Abstract：

:Melanomas accumulate a high burden of mutations that could potentially generate neoantigens, yet somehow suppress the immune response to facilitate continued growth. In this study, we identify a subset of human melanomas that have loss-of-function mutations in ATR, a kinase that recognizes and repairs UV-induced DNA damage and is required for cellular proliferation. ATR mutant tumors exhibit both the accumulation of multiple mutations and the altered expression of inflammatory genes, resulting in decreased T cell recruitment and increased recruitment of macrophages known to spur tumor invasion. Taken together, these studies identify a mechanism by which melanoma cells modulate the immune microenvironment to promote continued growth.

journal_name

Cell Rep

journal_title

Cell reports

authors

Chen CF,Ruiz-Vega R,Vasudeva P,Espitia F,Krasieva TB,de Feraudy S,Tromberg BJ,Huang S,Garner CP,Wu J,Hoon DS,Ganesan AK

doi

10.1016/j.celrep.2017.02.040

subject

Has Abstract

pub_date

2017-03-07 00:00:00

pages

2331-2342

issue

10

issn

2211-1247

pii

S2211-1247(17)30238-3

journal_volume

18

pub_type

杂志文章

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