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Enhancement of BLM-DNA2-Mediated Long-Range DNA End Resection by CtIP.

Abstract：

:DNA double-strand break repair by homologous recombination entails the resection of DNA ends to reveal ssDNA tails, which are used to invade a homologous DNA template. CtIP and its yeast ortholog Sae2 regulate the nuclease activity of MRE11 in the initial stage of resection. Deletion of CtIP in the mouse or SAE2 in yeast engenders a more severe phenotype than MRE11 nuclease inactivation, indicative of a broader role of CtIP/Sae2. Here, we provide biochemical evidence that CtIP promotes long-range resection via the BLM-DNA2 pathway. Specifically, CtIP interacts with BLM and enhances its helicase activity, and it enhances DNA cleavage by DNA2. Thus, CtIP influences multiple aspects of end resection beyond MRE11 regulation.

journal_name

Cell Rep

journal_title

Cell reports

authors

Daley JM,Jimenez-Sainz J,Wang W,Miller AS,Xue X,Nguyen KA,Jensen RB,Sung P

doi

10.1016/j.celrep.2017.09.048

subject

Has Abstract

pub_date

2017-10-10 00:00:00

pages

324-332

issue

2

issn

2211-1247

pii

S2211-1247(17)31338-4

journal_volume

21

pub_type

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