Abstract：
:Sex differences in autoimmunity and infection suggest that a better understanding of molecular sex differences will improve the diagnosis and treatment of immune-related disease. We identified 144 differentially expressed genes, referred to as immune sex expression signature (iSEXS), between human males and females using an integrated multi-cohort analysis of blood transcriptome profiles from six discovery cohorts from five continents with 458 healthy individuals. We validated iSEXS in 11 additional cohorts of 524 peripheral blood samples. When we separated iSEXS into genes located on sex chromosomes (XY-iSEXS) or autosomes (autosomal-iSEXS), both modules distinguished males and females. iSEXS reflects sex differences in immune cell proportions, with female-associated genes showing higher expression by CD4+ T cells and male-associated genes showing higher expression by myeloid cells. Autosomal-iSEXS detected an increase in monocytes with age in females, reflected sex-differential immune cell dynamics during influenza infection, and predicted antibody response in males, but not females.
journal_name
Cell Repjournal_title
Cell reportsauthors
Bongen E,Lucian H,Khatri A,Fragiadakis GK,Bjornson ZB,Nolan GP,Utz PJ,Khatri Pdoi
10.1016/j.celrep.2019.10.019subject
Has Abstractpub_date
2019-11-12 00:00:00pages
1961-1973.e4issue
7issn
2211-1247pii
S2211-1247(19)31319-1journal_volume
29pub_type
杂志文章相关文献
Cell Reports文献大全abstract：:Common fragile sites (CFSs) are genomic regions that display gaps and breaks in human metaphase chromosomes under replication stress and are often deleted in cancer cells. We studied an ∼300-bp subregion (Flex1) of human CFS FRA16D in yeast and found that it recapitulates characteristics of CFS fragility in human cell...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2019.03.103
更新日期：2019-04-23 00:00:00
abstract：:Oxytocin is a hormone with various actions. Oxytocin-containing parvocellular neurons project to the brainstem and spinal cord. Oxytocin release from these neurons suppresses nociception of inflammatory pain, the molecular mechanism of which remains unclear. Here, we report that the noxious stimulus receptor TRPV1 is ...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2017.10.063
更新日期：2017-11-07 00:00:00
abstract：:Intracellular transport and homeostasis of the endomembrane system in eukaryotic cells depend on the formation and fusion of vesicular carriers. Coat protein complex (COP) II vesicles export newly synthesized secretory proteins from the endoplasmic reticulum (ER), whereas COPI vesicles facilitate traffic from the Golg...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2018.12.041
更新日期：2019-01-02 00:00:00
abstract：:Early lineage-specific master regulators are essential for the specification of cell types. However, once cells are committed to a specific fate, it is critical to restrict the activity of such factors to enable differentiation. To date, it remains unclear how these factors are silenced. Using the Drosophila mesoderm ...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2020.108577
更新日期：2021-01-05 00:00:00
abstract：:Leptin has beneficial effects on glucose metabolism via actions in the hypothalamus, but the roles of specific subgroups of neurons responsible for these antidiabetic effects remain unresolved. We generated diabetic Lep(ob/ob) or Lepr(db/db) mice lacking or re-expressing leptin receptors (LepRb) in subgroups of neuron...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2014.04.010
更新日期：2014-05-22 00:00:00
abstract：:Major depressive disorder is associated with weight loss and decreased appetite; however, the signaling that connects these conditions is unclear. Here, we show that MC4R signaling in the dorsal raphe nucleus (DRN) affects feeding, anxiety, and depression. DRN infusion of α-MSH decreases DRN neuronal activation and fe...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2020.108267
更新日期：2020-10-13 00:00:00
abstract：:This study evaluates HIV antibody responses and their evolution during the course of HIV infection. A phage display system is used to characterize antibody binding to >3,300 HIV peptides in 57 adults with early- to late-stage infection. We find that the number of unique epitopes targeted ("antibody breadth") increases...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2019.03.097
更新日期：2019-04-30 00:00:00
abstract：:Organisms need to assess their nutritional state and adapt their digestive capacity to the demands for various nutrients. Modulation of digestive enzyme production represents a rational step to regulate nutriment uptake. However, the role of digestion in nutrient homeostasis has been largely neglected. In this study, ...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2014.08.064
更新日期：2014-10-09 00:00:00
abstract：:The transcription factor hepatic leukemia factor (HLF) is strongly expressed in hematopoietic stem cells (HSCs) and is thought to influence both HSC self-renewal and leukemogenesis. However, the physiological role of HLF in hematopoiesis and HSC function is unclear. Here, we report that mice lacking Hlf are viable wit...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2017.11.084
更新日期：2017-12-19 00:00:00
abstract：:Immunoglobulin M (IgM) memory cells undergo differentiation in germinal centers following antigen challenge, but the full effector cell potential of these cells is unknown. We monitored the differentiation of enhanced yellow fluorescent protein (eYFP)-labeled CD11c+ and CD11cneg T-bet+ IgM memory cells after their tra...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2018.06.074
更新日期：2018-07-24 00:00:00
abstract：:The twin-ATPase ABCE1 has a vital function in mRNA translation by recycling terminated or stalled ribosomes. As for other functionally distinct ATP-binding cassette (ABC) proteins, the mechanochemical coupling of ATP hydrolysis to conformational changes remains elusive. Here, we use an integrated biophysical approach ...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2019.06.052
更新日期：2019-07-16 00:00:00
abstract：:Tissue-resident memory T (TRM) cells provide key adaptive immune responses in infection, cancer, and autoimmunity. However, transcriptional heterogeneity of human intestinal TRM cells remains undefined. Here, we investigate transcriptional and functional heterogeneity of human TRM cells through study of donor-derived ...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2020.108661
更新日期：2021-01-19 00:00:00
abstract：:T and innate lymphoid cells (ILCs) share some aspects of their developmental programs. However, although Notch signaling is strictly required for T cell development, it is dispensable for fetal ILC development. Constitutive activation of Notch signaling, at the common lymphoid progenitor stage, drives T cell developme...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2016.01.015
更新日期：2016-02-16 00:00:00
abstract：:Small cytoplasmic mRNP granules are implicated in mRNA transport, translational control, and decay. Using super-resolution microscopy and fluorescence correlation spectroscopy, we analyzed the molecular composition and dynamics of single cytoplasmic YBX1_IMP1 mRNP granules in live cells. Granules appeared elongated an...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2019.09.018
更新日期：2019-10-15 00:00:00
abstract：:We use super-resolution interferometric photoactivation and localization microscopy (iPALM) and a constrained photoactivatable fluorescent protein integrin fusion to measure the displacement of the head of integrin lymphocyte function-associated 1 (LFA-1) resulting from integrin conformational change on the cell surfa...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2018.01.062
更新日期：2018-02-13 00:00:00
abstract：:Wiskott-Aldrich syndrome protein (WASp) is a main cytoskeletal regulator in B cells. WASp-interacting protein (WIP) binds to and stabilizes WASp but also interacts with actin. Using mice with a mutated actin binding domain of WIP (WIPΔABD), we here investigated the role of WIP binding to actin during B cell activation...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2018.06.051
更新日期：2018-07-17 00:00:00
abstract：:Fragile X mental retardation protein (FMRP) promotes cyclic AMP (cAMP) signaling. Using an in vivo protein kinase A activity sensor (PKA-SPARK), we find that Drosophila FMRP (dFMRP) and human FMRP (hFMRP) enhance PKA activity in a central brain learning and memory center. Increasing neuronal PKA activity suppresses FM...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2020.108266
更新日期：2020-10-13 00:00:00
abstract：:S1PR1 signaling has been shown to restrain the number and function of regulatory T (Treg) cells in the periphery under physiological conditions and in colitis models, but its role in regulating tumor-associated T cells is unknown. Here, we show that S1PR1 signaling in T cells drives Treg accumulation in tumors, limits...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2014.02.016
更新日期：2014-03-27 00:00:00
abstract：:Placental development is a key event in mammalian reproduction and embryogenesis. However, the molecular basis underlying placental development is not fully understood. Here, we conduct a forward genetic screen to identify regulators for extraembryonic development and identify Zfp281 as a key factor. Zfp281 overexpres...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2019.04.028
更新日期：2019-05-07 00:00:00
abstract：:Calcium signaling has long been associated with key events of immunity, including chemotaxis, phagocytosis, and activation. However, imaging and manipulation of calcium flux in motile immune cells in live animals remain challenging. Using light-sheet microscopy for in vivo calcium imaging in zebrafish, we observe char...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2015.11.010
更新日期：2015-12-15 00:00:00
abstract：:While the I kappa kinase (IKK) scaffolding protein NF-κB essential modulator (NEMO) binds to polyubiquitin chains to transmit inflammatory signals, NEMO itself is also ubiquitinated in response to a variety of inflammatory agonists. Although there have been hints that polyubiquitination of NEMO is essential for avoidi...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2013.06.036
更新日期：2013-07-25 00:00:00
abstract：:Oct4 is an essential regulator of pluripotency in vivo and in vitro in embryonic stem cells, as well as a key mediator of the reprogramming of somatic cells into induced pluripotent stem cells. It is not known whether activation and/or repression of specific genes by Oct4 is relevant to these functions. Here, we show ...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2011.12.002
更新日期：2012-02-23 00:00:00
abstract：:Circularization was recently recognized to broadly expand transcriptome complexity. Here, we exploit massive Drosophila total RNA-sequencing data, >5 billion paired-end reads from >100 libraries covering diverse developmental stages, tissues, and cultured cells, to rigorously annotate >2,500 fruit fly circular RNAs. T...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2014.10.062
更新日期：2014-12-11 00:00:00
abstract：:The role of the neurovascular niche in CNS myelin regeneration is incompletely understood. Here, we show that, upon demyelination, CNS-resident pericytes (PCs) proliferate, and parenchymal non-vessel-associated PC-like cells (PLCs) rapidly develop. During remyelination, mature oligodendrocytes were found in close prox...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2017.08.007
更新日期：2017-08-22 00:00:00
abstract：:Two-photon imaging with genetically encoded calcium indicators (GECIs) enables long-term observation of neuronal activity in vivo. However, there are very few studies of GECIs in primates. Here, we report a method for long-term imaging of a GECI, GCaMP6f, expressed from adeno-associated virus vectors in cortical neuro...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2015.10.050
更新日期：2015-12-01 00:00:00
abstract：:Accumulation of toxic amyloid oligomers is a key feature in the pathogenesis of amyloid-related diseases. Formation of mature amyloid fibrils is one defense mechanism to neutralize toxic prefibrillar oligomers. This mechanism is notably influenced by apolipoprotein E variants. Cells that produce mature amyloid fibrils...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2015.08.057
更新日期：2015-10-06 00:00:00
abstract：:The hormone αKlotho regulates lifespan in mice, as knockouts die early of what appears to be accelerated aging due to hyperphosphatemia and soft tissue calcification. In contrast, the overexpression of αKlotho increases lifespan. Given the severe mouse phenotype, we generated zebrafish mutants for αklotho as well as i...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2019.08.013
更新日期：2019-09-10 00:00:00
abstract：:In the absence of low-level ER-to-mitochondrial Ca(2+) transfer, ATP levels fall, and AMPK-dependent, mTOR-independent autophagy is induced as an essential survival mechanism in many cell types. Here, we demonstrate that tumorigenic cancer cell lines, transformed primary human fibroblasts, and tumors in vivo respond s...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2016.02.030
更新日期：2016-03-15 00:00:00
abstract：:Mutations of WD40-repeat protein 62 (WDR62) have been identified recently to cause human MCPH (autosomal-recessive primary microcephaly), a neurodevelopmental disorder characterized by decreased brain size. However, the underlying mechanism is unclear. Here, we investigate the function of WDR62 in brain development an...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2013.12.016
更新日期：2014-01-16 00:00:00
abstract：:The traditional view of macrolide antibiotics as plugs inside the ribosomal nascent peptide exit tunnel (NPET) has lately been challenged in favor of a more complex, heterogeneous mechanism, where drug-peptide interactions determine the fate of a translating ribosome. To investigate these highly dynamic processes, we ...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2014.04.034
更新日期：2014-06-12 00:00:00
