Hepatic Leukemia Factor Maintains Quiescence of Hematopoietic Stem Cells and Protects the Stem Cell Pool during Regeneration.

abstract：:Lung disease is a major cause of death in the United States, with current therapeutic approaches serving only to manage symptoms. The most common chronic and life-threatening genetic disease of the lung is cystic fibrosis (CF) caused by mutations in the cystic fibrosis transmembrane regulator (CFTR). We have generated...

journal_title：Cell reports

authors： Firth AL,Menon T,Parker GS,Qualls SJ,Lewis BM,Ke E,Dargitz CT,Wright R,Khanna A,Gage FH,Verma IM

更新日期：2015-09-01 00:00:00

abstract：:Brain plasticity is often restricted to critical periods in early life. Here, we show that a key regulator of this process in the visual cortex, Otx2 homeoprotein, is synthesized and secreted globally from the choroid plexus. Consequently, Otx2 is maintained in selected GABA cells unexpectedly throughout the mature fo...

journal_title：Cell reports

authors： Spatazza J,Lee HH,Di Nardo AA,Tibaldi L,Joliot A,Hensch TK,Prochiantz A

更新日期：2013-06-27 00:00:00

abstract：:Unconventional secretion of exosome vesicles from multivesicular endosomes (MVEs) occurs across a broad set of systems and is reported to be upregulated in cancer, where it promotes aggressive behavior. However, regulatory control of exosome secretion is poorly understood. Using cancer cells, we identified specialized...

journal_title：Cell reports

authors： Hoshino D,Kirkbride KC,Costello K,Clark ES,Sinha S,Grega-Larson N,Tyska MJ,Weaver AM

更新日期：2013-12-12 00:00:00

abstract：:The stress-activated protein kinases c-Jun N-terminal kinase (JNK) and p38 are important players in cell-fate decisions in response to environmental stress signals. Crosstalk signaling between JNK and p38 is emerging as an important regulatory mechanism in inflammatory and stress responses. However, it is unknown how ...

journal_title：Cell reports

authors： Miura H,Kondo Y,Matsuda M,Aoki K

更新日期：2018-09-04 00:00:00

abstract：:The joint contribution of pre-existing and de novo genetic variation to clonal adaptation is poorly understood but essential to designing successful antimicrobial or cancer therapies. To address this, we evolve genetically diverse populations of budding yeast, S. cerevisiae, consisting of diploid cells with unique hap...

journal_title：Cell reports

authors： Vázquez-García I,Salinas F,Li J,Fischer A,Barré B,Hallin J,Bergström A,Alonso-Perez E,Warringer J,Mustonen V,Liti G

更新日期：2017-10-17 00:00:00

abstract：:Plasmodium parasites are highly selective when infecting hepatocytes and induce many changes within the host cell upon infection. While several host cell factors have been identified that are important for liver infection, our understanding of what facilitates the maintenance of infection remains incomplete. Here, we ...

journal_title：Cell reports

authors： Glennon EKK,Austin LS,Arang N,Kain HS,Mast FD,Vijayan K,Aitchison JD,Kappe SHI,Kaushansky A

更新日期：2019-03-19 00:00:00

abstract：:Hippocampal sharp-wave ripples (SPW-Rs) support consolidation of recently acquired episodic memories and planning future actions by generating ordered neuronal sequences of previous or future experiences. SPW-Rs are characterized by several spectral components: a slow (5-15 Hz) sharp-wave, a high-frequency "ripple" os...

journal_title：Cell reports

authors： Oliva A,Fernández-Ruiz A,Fermino de Oliveira E,Buzsáki G

更新日期：2018-11-13 00:00:00

abstract：:Plasmodium parasites infect the liver and replicate inside hepatocytes before they invade erythrocytes and trigger clinical malaria. Analysis of host signaling pathways affected by liver-stage infection could provide critical insights into host-pathogen interactions and reveal targets for intervention. Using protein l...

journal_title：Cell reports

authors： Kaushansky A,Ye AS,Austin LS,Mikolajczak SA,Vaughan AM,Camargo N,Metzger PG,Douglass AN,MacBeath G,Kappe SH

更新日期：2013-03-28 00:00:00

abstract：:Human rhinovirus (HRV) causes upper respiratory infections and asthma exacerbations. We screened multiple orthologous RNAi reagents and identified host proteins that modulate HRV replication. Here, we show that RNASEK, a transmembrane protein, was needed for the replication of HRV, influenza A virus, and dengue virus....

journal_title：Cell reports

authors： Perreira JM,Aker AM,Savidis G,Chin CR,McDougall WM,Portmann JM,Meraner P,Smith MC,Rahman M,Baker RE,Gauthier A,Franti M,Brass AL

更新日期：2015-08-04 00:00:00

abstract：:To understand how the Bcl6 transcriptional repressor functions in the immune system, we disrupted its RD2 repression domain in mice. Bcl6RD2(MUT) mice exhibit a complete loss of germinal center (GC) formation but retain normal extrafollicular responses. Bcl6RD2(MUT) antigen-engaged B cells migrate to the interfollicul...

journal_title：Cell reports

authors： Huang C,Gonzalez DG,Cote CM,Jiang Y,Hatzi K,Teater M,Dai K,Hla T,Haberman AM,Melnick A

更新日期：2014-09-11 00:00:00

abstract：:Spondweni virus (SPOV) is the flavivirus that is most closely related to Zika virus (ZIKV). Although SPOV causes sporadic human infections in Africa, recently it was found in Culex mosquitoes in Haiti. To investigate the pathogenic spectrum of SPOV, we developed infection models in mice. Although two SPOV strains fail...

journal_title：Cell reports

authors： Salazar V,Jagger BW,Mongkolsapaya J,Burgomaster KE,Dejnirattisai W,Winkler ES,Fernandez E,Nelson CA,Fremont DH,Pierson TC,Crowe JE Jr,Screaton GR,Diamond MS

更新日期：2019-02-05 00:00:00

abstract：:The cerebral cortex is organized in vertical columns that contain neurons with similar functions. The cellular micro-architecture of such columns is an essential determinant of brain dynamics and cortical information processing. However, a detailed understanding of columns is incomplete, even in the best studied corti...

journal_title：Cell reports

authors： Tischbirek CH,Noda T,Tohmi M,Birkner A,Nelken I,Konnerth A

更新日期：2019-04-30 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a devastating disease that progresses from detachment of motor nerve terminals to complete muscle paralysis and lethal respiratory failure within 5 years of diagnosis. Genetic studies have linked mutations in several genes to ALS, and mice bearing mutations in SOD1 recapitulate h...

journal_title：Cell reports

authors： Pérez-García MJ,Burden SJ

更新日期：2012-09-27 00:00:00

abstract：:We examined hematopoietic protein kinase 1 (HPK1), whose reliance on scaffold versus kinase functions for negative immune cell regulation is poorly understood and critical to its assessment as a viable drug target. We identify kinase-dependent roles for HPK1 in CD8 T cells that restrict their anti-viral and anti-tumor...

journal_title：Cell reports

authors： Hernandez S,Qing J,Thibodeau RH,Du X,Park S,Lee HM,Xu M,Oh S,Navarro A,Roose-Girma M,Newman RJ,Warming S,Nannini M,Sampath D,Kim JM,Grogan JL,Mellman I

更新日期：2018-10-02 00:00:00

abstract：:Embryonic stem cells (ESCs) hold promise for the treatment of many medical conditions; however, their utility is limited by immune rejection. The objective of our study is to establish tolerance or promote engraftment of transplanted ESCs as well as mature cell populations derived from ESCs. Luciferase (luc(+))-expres...

journal_title：Cell reports

authors： Pan Y,Leveson-Gower DB,de Almeida PE,Pierini A,Baker J,Florek M,Nishikii H,Kim BS,Ke R,Wu JC,Negrin RS

更新日期：2015-03-24 00:00:00

abstract：:Neuregulin-1 (NRG1) gene variants are associated with increased genetic risk for schizophrenia. It is unclear whether risk haplotypes cause elevated or decreased expression of NRG1 in the brains of schizophrenia patients, given that both findings have been reported from autopsy studies. To study NRG1 functions in vivo...

journal_title：Cell reports

authors： Agarwal A,Zhang M,Trembak-Duff I,Unterbarnscheidt T,Radyushkin K,Dibaj P,Martins de Souza D,Boretius S,Brzózka MM,Steffens H,Berning S,Teng Z,Gummert MN,Tantra M,Guest PC,Willig KI,Frahm J,Hell SW,Bahn S,Rossner MJ

更新日期：2014-08-21 00:00:00

abstract：:At presynaptic active zones, exocytosis of neurotransmitter vesicles (SVs) is driven by SNARE complexes that recruit Syb2 and SNAP25. However, it remains unknown which SNAREs promote the secretion of neuronal proteins, including those essential for circuit development and experience-dependent plasticity. Here we demon...

journal_title：Cell reports

authors： Shimojo M,Courchet J,Pieraut S,Torabi-Rander N,Sando R 3rd,Polleux F,Maximov A

更新日期：2015-05-19 00:00:00

abstract：:The histone lysine demethylase KDM4C is often overexpressed in cancers primarily through gene amplification. The molecular mechanisms of KDM4C action in tumorigenesis are not well defined. Here, we report that KDM4C transcriptionally activates amino acid biosynthesis and transport, leading to a significant increase in...

journal_title：Cell reports

authors： Zhao E,Ding J,Xia Y,Liu M,Ye B,Choi JH,Yan C,Dong Z,Huang S,Zha Y,Yang L,Cui H,Ding HF

更新日期：2016-01-26 00:00:00

abstract：:Ubiquitin and ubiquitin-like chains are finely balanced by conjugating and de-conjugating enzymes. Alterations in this balance trigger the response to stress conditions and are often observed in pathologies. How such changes are detected is not well understood. We identify the HSP70 chaperone as a sensor of changes in...

journal_title：Cell reports

authors： Bailly AP,Perrin A,Serrano-Macia M,Maghames C,Leidecker O,Trauchessec H,Martinez-Chantar ML,Gartner A,Xirodimas DP

更新日期：2019-10-01 00:00:00

abstract：:Organismal death is a process of systemic collapse whose mechanisms are less well understood than those of cell death. We previously reported that death in C. elegans is accompanied by a calcium-propagated wave of intestinal necrosis, marked by a wave of blue autofluorescence (death fluorescence). Here, we describe an...

journal_title：Cell reports

authors： Galimov ER,Pryor RE,Poole SE,Benedetto A,Pincus Z,Gems D

更新日期：2018-03-06 00:00:00

abstract：:The spindle assembly checkpoint (SAC) prevents premature segregation of chromosomes during mitosis. This process requires structural remodeling of MAD2 from O-MAD2 to C-MAD2 conformation. After the checkpoint is satisfied, C-MAD2 is reverted to O-MAD2 to allow anaphase-promoting complex/cyclosome (APC/C) to trigger an...

journal_title：Cell reports

authors： Ma HT,Poon RYC

更新日期：2018-02-06 00:00:00

abstract：:Both strands of human mtDNA are transcribed in continuous, multigenic units that are cleaved into the mature rRNAs, tRNAs, and mRNAs required for respiratory chain biogenesis. We sought to systematically identify nuclear-encoded proteins that contribute to processing of mtRNAs within the organelle. First, we devised a...

journal_title：Cell reports

authors： Wolf AR,Mootha VK

更新日期：2014-05-08 00:00:00

abstract：:Lysine-Specific Demethylase 1 (LSD1, KDM1A) functions as a transcriptional corepressor through demethylation of histone 3 lysine 4 (H3K4) but has a coactivator function on some genes through mechanisms that are unclear. We show that LSD1, interacting with CoREST, associates with and coactivates androgen receptor (AR) ...

journal_title：Cell reports

authors： Cai C,He HH,Gao S,Chen S,Yu Z,Gao Y,Chen S,Chen MW,Zhang J,Ahmed M,Wang Y,Metzger E,Schüle R,Liu XS,Brown M,Balk SP

更新日期：2014-12-11 00:00:00

abstract：:The JAK/STAT1 pathway is generally activated by cytokines, providing essential antiviral defense. Here, we identify that STAT1 activation is independent of cytokines and JAKs at the early infection stage of some viruses, including influenza A virus (IAV). Instead, STAT1 is activated mainly through spleen tyrosine kina...

journal_title：Cell reports

authors： Liu S,Liao Y,Chen B,Chen Y,Yu Z,Wei H,Zhang L,Huang S,Rothman PB,Gao GF,Chen JL

更新日期：2021-01-19 00:00:00

abstract：:Oncogenic Ras plays a key role in cancer initiation but also contributes to malignant phenotypes by stimulating nutrient uptake and promoting invasive migration. Because these latter cellular responses require Rac-mediated remodeling of the actin cytoskeleton, we hypothesized that molecules involved in Rac activation ...

journal_title：Cell reports

authors： Tajiri H,Uruno T,Shirai T,Takaya D,Matsunaga S,Setoyama D,Watanabe M,Kukimoto-Niino M,Oisaki K,Ushijima M,Sanematsu F,Honma T,Terada T,Oki E,Shirasawa S,Maehara Y,Kang D,Côté JF,Yokoyama S,Kanai M,Fukui Y

更新日期：2017-05-02 00:00:00

abstract：:In mammals, the noncoding Xist RNA triggers transcriptional silencing of one of the two X chromosomes in female cells. Here, we report a genetic screen for silencing factors in X chromosome inactivation using haploid mouse embryonic stem cells (ESCs) that carry an engineered selectable reporter system. This system was...

journal_title：Cell reports

authors： Monfort A,Di Minin G,Postlmayr A,Freimann R,Arieti F,Thore S,Wutz A

更新日期：2015-07-28 00:00:00

abstract：:Stable unannotated transcripts (SUTs), some of which overlap protein-coding genes in antisense direction, are a class of non-coding RNAs. While case studies have reported important regulatory roles for several of such RNAs, their general impact on protein abundance regulation of the overlapping gene is not known. To t...

journal_title：Cell reports

authors： Huber F,Bunina D,Gupta I,Khmelinskii A,Meurer M,Theer P,Steinmetz LM,Knop M

更新日期：2016-06-21 00:00:00

abstract：:Large-scale, cooperative rearrangements underlie the functions of RNA in RNA-protein machines and gene regulation. To understand how such rearrangements are orchestrated, we used high-throughput chemical footprinting to dissect a seemingly concerted rearrangement in P5abc RNA, a paradigm of RNA folding studies. With m...

journal_title：Cell reports

authors： Gracia B,Al-Hashimi HM,Bisaria N,Das R,Herschlag D,Russell R

更新日期：2018-03-20 00:00:00

abstract：:Insulin stimulates glucose uptake through the membrane translocation of GLUT4 and GLUT1. Peroxisome proliferator-activated receptor γ (PPARγ) enhances insulin sensitivity. Here, we demonstrate that insulin stimulates GLUT4 and GLUT1 translocation, and glucose uptake, by activating the signaling pathway involving nicot...

journal_title：Cell reports

authors： Song EK,Lee YR,Kim YR,Yeom JH,Yoo CH,Kim HK,Park HM,Kang HS,Kim JS,Kim UH,Han MK

更新日期：2012-12-27 00:00:00

abstract：:Presenilin 1 (PS1) is the catalytic core of γ-secretase, which cleaves type 1 transmembrane proteins, including the amyloid precursor protein (APP). PS1 also has γ-secretase-independent functions, and dominant PS1 missense mutations are the most common cause of familial Alzheimer's disease (FAD). Whether PS1 FAD mutat...

journal_title：Cell reports

authors： Woodruff G,Young JE,Martinez FJ,Buen F,Gore A,Kinaga J,Li Z,Yuan SH,Zhang K,Goldstein LS

更新日期：2013-11-27 00:00:00