Anti-microbial Functions of Group 3 Innate Lymphoid Cells in Gut-Associated Lymphoid Tissues Are Regulated by G-Protein-Coupled Receptor 183.

abstract：:CRISPR genome engineering has become a powerful tool to functionally investigate the complex mechanisms of immune system regulation. While decades of work have aimed to genetically reprogram innate immunity, the utility of current approaches is restricted by poor knockout efficiencies or limited specificity for mature...

journal_title：Cell reports

authors： Riggan L,Hildreth AD,Rolot M,Wong YY,Satyadi W,Sun R,Huerta C,O'Sullivan TE

更新日期：2020-05-19 00:00:00

abstract：:In fission yeast, the transcription factor Pap1 undergoes H2O2-dependent oxidation that promotes its nuclear accumulation and the activation of an antioxidant gene program. However, the mechanisms that regulate the sensitivity and selectivity of Pap1 activation by peroxides are not fully understood. Here, we demonstra...

journal_title：Cell reports

authors： Calvo IA,Boronat S,Domènech A,García-Santamarina S,Ayté J,Hidalgo E

更新日期：2013-12-12 00:00:00

abstract：:Preventing transcription-replication head-on conflict (HO-TRC)-triggered R-loop formation is essential for maintaining genome integrity in bacteria, plants, and mammals. The R-loop eraser RNase H can efficiently relax HO-TRCs. However, it is not clear how organisms resist HO-TRC-triggered R-loops when RNase H proteins...

journal_title：Cell reports

authors： Yang Z,Li M,Sun Q

更新日期：2020-01-07 00:00:00

abstract：:DNA polymerase ζ (Polζ) is specialized for the extension step of translesion DNA synthesis (TLS). Despite its central role in maintaining genome integrity, little is known about its overall architecture. Initially identified as a heterodimer of the catalytic subunit Rev3 and the accessory subunit Rev7, yeast Polζ has ...

journal_title：Cell reports

authors： Gómez-Llorente Y,Malik R,Jain R,Choudhury JR,Johnson RE,Prakash L,Prakash S,Ubarretxena-Belandia I,Aggarwal AK

更新日期：2013-10-17 00:00:00

abstract：:Chromatin regulation is driven by multicomponent protein complexes, which form functional modules. Deciphering the components of these modules and their interactions is central to understanding the molecular pathways these proteins are regulating, their functions, and their relation to both normal development and dise...

journal_title：Cell reports

authors： Marcon E,Ni Z,Pu S,Turinsky AL,Trimble SS,Olsen JB,Silverman-Gavrila R,Silverman-Gavrila L,Phanse S,Guo H,Zhong G,Guo X,Young P,Bailey S,Roudeva D,Zhao D,Hewel J,Li J,Gräslund S,Paduch M,Kossiakoff AA,Lupien M,

更新日期：2014-07-10 00:00:00

abstract：:Heterobifunctional proteolysis-targeting chimeric compounds leverage the activity of E3 ligases to induce degradation of target oncoproteins and exhibit potent preclinical antitumor activity. To dissect the mechanisms regulating tumor cell sensitivity to different classes of pharmacological "degraders" of oncoproteins...

journal_title：Cell reports

authors： Shirasaki R,Matthews GM,Gandolfi S,de Matos Simoes R,Buckley DL,Raja Vora J,Sievers QL,Brüggenthies JB,Dashevsky O,Poarch H,Tang H,Bariteau MA,Sheffer M,Hu Y,Downey-Kopyscinski SL,Hengeveld PJ,Glassner BJ,Dhimolea E,O

更新日期：2021-01-05 00:00:00

abstract：:Information gained during goal pursuit motivates adaptive behavior. The anterior cingulate cortex (ACC) supports adaptive behavior, but how ACC signals are translated into motivational signals remains unclear. Rats with implants in the ACC and ventral tegmental area (VTA), a dopaminergic brain area implicated in motiv...

journal_title：Cell reports

authors： Elston TW,Bilkey DK

更新日期：2017-06-13 00:00:00

abstract：:The cytokine interleukin-1β (IL-1β) is critical for antimicrobial defenses; the inflammasome pathway typically controls IL-1β release, but pathogens often evade this pathway. In this issue, Donado et al. (2020) describe an alternative, two-cell model, to instruct inflammasome-independent IL-1β release. ...

journal_title：Cell reports

authors： Bezbradica JS,Joyce S

更新日期：2020-04-07 00:00:00

abstract：:In neurons, transmembrane proteins are targeted to dendrites in vesicles that traffic solely within the somatodendritic compartment. How these vesicles are retained within the somatodendritic domain is unknown. Here, we use a novel pulse-chase system, which allows synchronous release of exogenous transmembrane protein...

journal_title：Cell reports

authors： Al-Bassam S,Xu M,Wandless TJ,Arnold DB

更新日期：2012-07-26 00:00:00

abstract：:Replication of a damaged DNA template can threaten the integrity of the genome, requiring the use of various mechanisms to tolerate DNA lesions. The Smc5/6 complex, together with the Nse2/Mms21 SUMO ligase, plays essential roles in genome stability through undefined tasks at damaged replication forks. Various subunits...

journal_title：Cell reports

authors： Zapatka M,Pociño-Merino I,Heluani-Gahete H,Bermúdez-López M,Tarrés M,Ibars E,Solé-Soler R,Gutiérrez-Escribano P,Apostolova S,Casas C,Aragon L,Wellinger R,Colomina N,Torres-Rosell J

更新日期：2019-12-03 00:00:00

abstract：:Oxytocin is a hormone with various actions. Oxytocin-containing parvocellular neurons project to the brainstem and spinal cord. Oxytocin release from these neurons suppresses nociception of inflammatory pain, the molecular mechanism of which remains unclear. Here, we report that the noxious stimulus receptor TRPV1 is ...

journal_title：Cell reports

authors： Nersesyan Y,Demirkhanyan L,Cabezas-Bratesco D,Oakes V,Kusuda R,Dawson T,Sun X,Cao C,Cohen AM,Chelluboina B,Veeravalli KK,Zimmermann K,Domene C,Brauchi S,Zakharian E

更新日期：2017-11-07 00:00:00

abstract：:Macrophages exist predominantly in two distinct states, G0 and a G1-like state that is accompanied by phosphorylation of SAMHD1 at T592. Here, we demonstrate that Toll-like receptor 4 (TLR4) activation can potently induce G0 arrest and SAMHD1 antiretroviral activity by an interferon (IFN)-independent pathway. This pat...

journal_title：Cell reports

authors： Mlcochova P,Winstone H,Zuliani-Alvarez L,Gupta RK

更新日期：2020-03-24 00:00:00

abstract：:Thymic epithelial cells (TECs) are critically required for T cell development, but the cellular mechanisms that maintain adult TECs are poorly understood. Here, we show that a previously unidentified subpopulation, EpCam(+)UEA1(-)Ly-51(+)PLET1(+)MHC class II(hi), which comprises <0.5% of adult TECs, contains bipotent ...

journal_title：Cell reports

authors： Ulyanchenko S,O'Neill KE,Medley T,Farley AM,Vaidya HJ,Cook AM,Blair NF,Blackburn CC

更新日期：2016-03-29 00:00:00

abstract：:Alternatively activated (M2) macrophages promote wound healing but weaken antimicrobial defenses. The mechanisms that enforce macrophage divergence and dictate the phenotypic and metabolic characteristics of M2 macrophages remain elusive. We show that alternative activation with interleukin (IL)-4 induces expression o...

journal_title：Cell reports

authors： Chowdhury D,Alrefai H,Landero Figueroa JA,Candor K,Porollo A,Fecher R,Divanovic S,Deepe GS Jr,Subramanian Vignesh K

更新日期：2019-06-25 00:00:00

abstract：:Endophilin-A, a well-characterized endocytic adaptor essential for synaptic vesicle recycling, has recently been linked to neurodegeneration. We report here that endophilin-A deficiency results in impaired movement, age-dependent ataxia, and neurodegeneration in mice. Transcriptional analysis of endophilin-A mutant mi...

journal_title：Cell reports

authors： Murdoch JD,Rostosky CM,Gowrisankaran S,Arora AS,Soukup SF,Vidal R,Capece V,Freytag S,Fischer A,Verstreken P,Bonn S,Raimundo N,Milosevic I

更新日期：2016-10-18 00:00:00

abstract：:Many favorable metabolic effects have been attributed to thermogenic activity of brown adipose tissue (BAT). Yet, time of day has rarely been considered in this field of research. Here, we show that a diurnal rhythm in BAT activity regulates plasma lipid metabolism. We observed a high-amplitude rhythm in fatty acid up...

journal_title：Cell reports

authors： van den Berg R,Kooijman S,Noordam R,Ramkisoensing A,Abreu-Vieira G,Tambyrajah LL,Dijk W,Ruppert P,Mol IM,Kramar B,Caputo R,Puig LS,de Ruiter EM,Kroon J,Hoekstra M,van der Sluis RJ,Meijer OC,Willems van Dijk K,van Kerk

更新日期：2018-03-27 00:00:00

abstract：:Eukaryotic cells use two principal mechanisms for repairing DNA double-strand breaks (DSBs): homologous recombination (HR) and nonhomologous end-joining (NHEJ). DSB repair pathway choice is strongly regulated during the cell cycle. Cyclin-dependent kinase 1 (Cdk1) activates HR by phosphorylation of key recombination f...

journal_title：Cell reports

authors： Hentges P,Waller H,Reis CC,Ferreira MG,Doherty AJ

更新日期：2014-12-24 00:00:00

abstract：:It has been proposed that sleep's contribution to memory consolidation is to reactivate prior encoded information. To elucidate the neural mechanisms carrying reactivation-related mnemonic information, we investigated whether content-specific memory signatures associated with memory reactivation during wakefulness reo...

journal_title：Cell reports

authors： Schreiner T,Doeller CF,Jensen O,Rasch B,Staudigl T

更新日期：2018-10-09 00:00:00

abstract：:Nuclear factor κB (NF-κB) RelA is the potent transcriptional activator of inflammatory response genes. We stringently defined a list of direct RelA target genes by integrating physical (chromatin immunoprecipitation sequencing [ChIP-seq]) and functional (RNA sequencing [RNA-seq] in knockouts) datasets. We then dissect...

journal_title：Cell reports

authors： Ngo KA,Kishimoto K,Davis-Turak J,Pimplaskar A,Cheng Z,Spreafico R,Chen EY,Tam A,Ghosh G,Mitchell S,Hoffmann A

更新日期：2020-02-25 00:00:00

abstract：:The mammalian heart is incapable of regenerating a sufficient number of cardiomyocytes to ameliorate the loss of contractile muscle after acute myocardial injury. Several reports have demonstrated that mononucleated cardiomyocytes are more responsive than are binucleated cardiomyocytes to pro-proliferative stimuli. We...

journal_title：Cell reports

authors： Windmueller R,Leach JP,Babu A,Zhou S,Morley MP,Wakabayashi A,Petrenko NB,Viatour P,Morrisey EE

更新日期：2020-03-03 00:00:00

abstract：:Viral vectors enable foreign proteins to be expressed in brains of non-genetic species, including non-human primates. However, viruses targeting specific neuron classes have proved elusive. Here we describe viral promoters and strategies for accessing GABAergic interneurons and their molecularly defined subsets in the...

journal_title：Cell reports

authors： Mehta P,Kreeger L,Wylie DC,Pattadkal JJ,Lusignan T,Davis MJ,Turi GF,Li WK,Whitmire MP,Chen Y,Kajs BL,Seidemann E,Priebe NJ,Losonczy A,Zemelman BV

更新日期：2019-03-05 00:00:00

abstract：:The deadly malaria parasite Plasmodium falciparum contains a nonphotosynthetic plastid, known as the apicoplast, that functions to produce essential metabolites, and drugs that target the apicoplast are clinically effective. Several prokaryotic caseinolytic protease (Clp) genes have been identified in the Plasmodium g...

journal_title：Cell reports

authors： Florentin A,Cobb DW,Fishburn JD,Cipriano MJ,Kim PS,Fierro MA,Striepen B,Muralidharan V

更新日期：2017-11-14 00:00:00

abstract：:Gambogic acid (GA) is a natural compound derived from Chinese herbs that has been approved by the Chinese Food and Drug Administration for clinical trials in cancer patients; however, its molecular targets have not been thoroughly studied. Here, we report that GA inhibits tumor proteasome activity, with potency compar...

journal_title：Cell reports

authors： Li X,Liu S,Huang H,Liu N,Zhao C,Liao S,Yang C,Liu Y,Zhao C,Li S,Lu X,Liu C,Guan L,Zhao K,Shi X,Song W,Zhou P,Dong X,Guo H,Wen G,Zhang C,Jiang L,Ma N,Li B,Wang S,Tan H,Wang X,Dou QP,Liu J

更新日期：2013-01-31 00:00:00

abstract：:Many infections are caused by pathogens that are similar, but not identical, to previously encountered viruses, bacteria, or vaccines. In such re-infections, pathogens introduce known antigens, which are recognized by memory T cells and new antigens that activate naive T cells. How preexisting memory T cells impact th...

journal_title：Cell reports

authors： Oberle SG,Hanna-El-Daher L,Chennupati V,Enouz S,Scherer S,Prlic M,Zehn D

更新日期：2016-10-11 00:00:00

abstract：:A central paradigm in the field of lymphocyte biology asserts that replicatively senescent memory T cells express the carbohydrate epitope CD57. These cells nonetheless accumulate with age and expand numerically in response to persistent antigenic stimulation. Here, we use in vivo deuterium labeling and ex vivo analys...

journal_title：Cell reports

authors： Ahmed R,Miners KL,Lahoz-Beneytez J,Jones RE,Roger L,Baboonian C,Zhang Y,Wang ECY,Hellerstein MK,McCune JM,Baird DM,Price DA,Macallan DC,Asquith B,Ladell K

更新日期：2020-12-15 00:00:00

abstract：:Glucose-stimulated insulin secretion from islet β cells is mediated by KATP channels. However, the role of non-KATP K+ channels in insulin secretion is largely unknown. Here, we show that a non-KATP K+ channel, KCNH6, plays a key role in insulin secretion and glucose hemostasis in humans and mice. KCNH6 p.P235L hetero...

journal_title：Cell reports

authors： Yang JK,Lu J,Yuan SS,Asan,Cao X,Qiu HY,Shi TT,Yang FY,Li Q,Liu CP,Wu Q,Wang YH,Huang HX,Kayoumu A,Feng JP,Xie RR,Zhu XR,Liu C,Yang GR,Zhang MR,Xie CL,Chen C,Zhang B,Liu G,Zhang XQ,Xu A

更新日期：2018-12-26 00:00:00

abstract：:Revascularization of ischemic skeletal muscle is governed by a balance between pro- and antiangiogenic factors in multiple cell types but particularly in myocytes and endothelial cells. Whereas the regulators of proangiogenic factors are well defined (e.g., hypoxia-inducible factor [HIF]), the transcriptional pathways...

journal_title：Cell reports

authors： Yadav V,Matsakas A,Lorca S,Narkar VA

更新日期：2014-08-07 00:00:00

abstract：:MicroRNAs (miRNAs) regulate diverse biological processes by repressing mRNAs, but their modest effects on direct targets, together with their participation in larger regulatory networks, make it challenging to delineate miRNA-mediated effects. Here, we describe an approach to characterizing miRNA-regulatory networks b...

journal_title：Cell reports

authors： Gosline SJ,Gurtan AM,JnBaptiste CK,Bosson A,Milani P,Dalin S,Matthews BJ,Yap YS,Sharp PA,Fraenkel E

更新日期：2016-01-12 00:00:00

abstract：:Oncogenic mutations of FLT3 and KIT receptors are associated with poor survival in patients with acute myeloid leukemia (AML) and myeloproliferative neoplasms (MPNs), and currently available drugs are largely ineffective. Although Stat5 has been implicated in regulating several myeloid and lymphoid malignancies, how p...

journal_title：Cell reports

authors： Chatterjee A,Ghosh J,Ramdas B,Mali RS,Martin H,Kobayashi M,Vemula S,Canela VH,Waskow ER,Visconte V,Tiu RV,Smith CC,Shah N,Bunting KD,Boswell HS,Liu Y,Chan RJ,Kapur R

更新日期：2014-11-20 00:00:00

abstract：:Kinase inhibitors represent the backbone of targeted cancer therapy, yet only a limited number of oncogenic drivers are directly druggable. By interrogating the activity of 1,505 kinase inhibitors, we found that BRD4-NUT-rearranged NUT midline carcinoma (NMC) cells are specifically killed by CDK9 inhibition (CDK9i) an...

journal_title：Cell reports

authors： Brägelmann J,Dammert MA,Dietlein F,Heuckmann JM,Choidas A,Böhm S,Richters A,Basu D,Tischler V,Lorenz C,Habenberger P,Fang Z,Ortiz-Cuaran S,Leenders F,Eickhoff J,Koch U,Getlik M,Termathe M,Sallouh M,Greff Z,Varga Z

更新日期：2017-09-19 00:00:00