Abstract：
:Glucose-stimulated insulin secretion from islet β cells is mediated by KATP channels. However, the role of non-KATP K+ channels in insulin secretion is largely unknown. Here, we show that a non-KATP K+ channel, KCNH6, plays a key role in insulin secretion and glucose hemostasis in humans and mice. KCNH6 p.P235L heterozygous mutation co-separated with diabetes in a four-generation pedigree. Kcnh6 knockout (KO) or Kcnh6 p.P235L knockin (KI) mice had a phenotype characterized by changing from hypoglycemia with hyperinsulinemia to hyperglycemia with insulin deficiency. Islets from the young KO mice had increased intracellular calcium concentration and increased insulin secretion. However, islets from the adult KO mice not only had increased intracellular calcium levels but also had remarkable ER stress and apoptosis, associated with loss of β cell mass and decreased insulin secretion. Therefore, dysfunction of KCNH6 causes overstimulation of insulin secretion in the short term and β cell failure in the long term.
journal_name
Cell Repjournal_title
Cell reportsauthors
Yang JK,Lu J,Yuan SS,Asan,Cao X,Qiu HY,Shi TT,Yang FY,Li Q,Liu CP,Wu Q,Wang YH,Huang HX,Kayoumu A,Feng JP,Xie RR,Zhu XR,Liu C,Yang GR,Zhang MR,Xie CL,Chen C,Zhang B,Liu G,Zhang XQ,Xu Adoi
10.1016/j.celrep.2018.12.005subject
Has Abstractpub_date
2018-12-26 00:00:00pages
3800-3810.e6issue
13issn
2211-1247pii
S2211-1247(18)31916-8journal_volume
25pub_type
杂志文章相关文献
Cell Reports文献大全abstract：:The timing of food intake and nutrient utilization is critical to health and regulated partly by the circadian clock. Increased amplitude of circadian oscillations and metabolic output has been found to improve health in diabetic and obesity mouse models. Here, we report a function for the circadian deadenylase Noctur...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2018.01.011
更新日期：2018-01-30 00:00:00
abstract：:The regulation of innervation by target-derived factors like nerve growth factor (NGF) is the cornerstone of neurotrophic theory. Whereas autocrine signaling in neurons affecting survival and axon growth has been described, it is difficult to reconcile autocrine signaling with the idea that targets control their inner...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2015.02.016
更新日期：2015-03-10 00:00:00
abstract：:Recently developed brain stimulation techniques have significantly advanced our ability to manipulate the brain's function. However, stimulating specific neurons in a desired region without significant surgical invasion remains a challenge. Here, we demonstrate a neuron-specific and region-targeted neural excitation s...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2020.108033
更新日期：2020-08-18 00:00:00
abstract：:Hippocampal sharp-wave ripples (SPW-Rs) support consolidation of recently acquired episodic memories and planning future actions by generating ordered neuronal sequences of previous or future experiences. SPW-Rs are characterized by several spectral components: a slow (5-15 Hz) sharp-wave, a high-frequency "ripple" os...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2018.10.066
更新日期：2018-11-13 00:00:00
abstract：:Whereas hundreds of cells in the mouse embryonic aorta transdifferentiate to hematopoietic cells, only very few establish hematopoietic stem cell (HSC) identity at a single time point. The Gata2 transcription factor is essential for HSC generation and function. In contrast to surface-marker-based cell isolation, Gata2...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2020.107627
更新日期：2020-05-12 00:00:00
abstract：:Tumor suppressor p53 regulates transcription of stress-response genes. Many p53 targets remain undiscovered because of uncertainty as to where p53 binds in the genome and the fact that few genes reside near p53-bound recognition elements (REs). Using chromatin immunoprecipitation followed by exonuclease treatment (ChI...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2014.06.030
更新日期：2014-07-24 00:00:00
abstract：:Cell-cycle arrest in quiescence and senescence is largely orchestrated by the retinoblastoma (Rb) tumor-suppressor pathway, but the mechanisms underlying the quiescence-senescence switch remain unclear. Here, we show that the crosstalk between the Rb-AKT-signaling pathways forms this switch by controlling the overlapp...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2014.03.006
更新日期：2014-04-10 00:00:00
abstract：:Neurogenesis continues in the ventricular-subventricular zone (V-SVZ) of the adult forebrain from quiescent neural stem cells (NSCs). V-SVZ NSCs are a reservoir for new olfactory bulb (OB) neurons that migrate through the rostral migratory stream (RMS). To generate neurons, V-SVZ NSCs need to activate and enter the ce...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2017.12.094
更新日期：2018-01-23 00:00:00
abstract：:Graft-versus-host disease (GVHD) limits the success of allogeneic hematopoietic cell transplantation (allo-HCT). Lysosomal acid lipase (LAL) mediates the intrinsic lipolysis of cells to generate free fatty acids (FFAs), which play an essential role in the development, proliferation, and function of T cells. Here, we f...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2020.108316
更新日期：2020-10-27 00:00:00
abstract：:The NMDA spike is a long-lasting nonlinear phenomenon initiated locally in the dendritic branches of a variety of cortical neurons. It plays a key role in synaptic plasticity and in single-neuron computations. Combining dynamic system theory and computational approaches, we now explore how the timing of synaptic inhib...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2017.10.035
更新日期：2017-11-07 00:00:00
abstract：:This study evaluates HIV antibody responses and their evolution during the course of HIV infection. A phage display system is used to characterize antibody binding to >3,300 HIV peptides in 57 adults with early- to late-stage infection. We find that the number of unique epitopes targeted ("antibody breadth") increases...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2019.03.097
更新日期：2019-04-30 00:00:00
abstract：:CRISPR-Cas13a enzymes are RNA-guided, RNA-activated RNases. Their properties have been exploited as powerful tools for RNA detection, RNA imaging, and RNA regulation. However, the relationship between target RNA binding and HEPN (higher eukaryotes and prokaryotes nucleotide binding) domain nuclease activation is poorl...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2018.06.105
更新日期：2018-07-24 00:00:00
abstract：:RNAi screens have implicated hundreds of host proteins as HIV-1 dependency factors (HDFs). While informative, these early studies overlap poorly due to false positives and false negatives. To ameliorate these issues, we combined information from the existing HDF screens together with new screens performed with multipl...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2014.09.031
更新日期：2014-10-23 00:00:00
abstract：:The enteroinvasive bacterium Shigella flexneri forces its uptake into non-phagocytic host cells through the translocation of T3SS effectors that subvert the actin cytoskeleton. Here, we report de novo actin polymerization after cellular entry around the bacterium-containing vacuole (BCV) leading to the formation of a ...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2020.107638
更新日期：2020-05-12 00:00:00
abstract：:The onset of anaphase is triggered by activation of the anaphase-promoting complex/cyclosome (APC/C) following silencing of the spindle assembly checkpoint (SAC). APC/C triggers ubiquitination of Securin and Cyclin B, which leads to loss of sister chromatid cohesion and inactivation of Cyclin B/Cdk1, respectively. Thi...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2017.01.032
更新日期：2017-02-07 00:00:00
abstract：:The transmission of malaria parasites to mosquitoes relies on the rapid induction of sexual reproduction upon their ingestion into a blood meal. Haploid female and male gametocytes become activated and emerge from their host cells, and the males enter the cell cycle to produce eight microgametes. The synchronized natu...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2017.10.071
更新日期：2017-11-14 00:00:00
abstract：:In Escherichia coli, bidirectional chromosomal replication is accompanied by the colocalization of sister replication forks. However, the biological significance of this mechanism and the key factors involved are still largely unknown. In this study, we found that a protein, termed CrfC, helps sustain the colocalizati...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2013.07.040
更新日期：2013-09-12 00:00:00
abstract：:In metazoans, the nuclear envelope (NE) breakdown (NEBD) occurs during "open" mitosis and meiosis. In the fission yeast Schizosaccharomyces pombe, the mitosis and the first meiotic division (MI) are "closed," during which the NE is maintained. Intriguingly, during the second meiotic division (MII), the NE is also main...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2018.03.073
更新日期：2018-04-24 00:00:00
abstract：:Dorsal root ganglia (DRG) relay sensory information to the brain, giving rise to the perception of pain, disorders of which are prevalent and burdensome. Here, we mapped expression quantitative trait loci (eQTLs) in a collection of human DRGs. DRG eQTLs were enriched within untranslated regions of coding genes of low ...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2017.05.018
更新日期：2017-05-30 00:00:00
abstract：:The molecular basis of higher regenerative capacity of cold-blooded animals comparing to warm-blooded ones is poorly understood. Although this difference in regenerative capacities is commonly thought to be a result of restructuring of the same regulatory gene network, we hypothesized that it may be due to loss of som...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2019.09.038
更新日期：2019-10-22 00:00:00
abstract：:The proneural transcription factor Ascl1 coordinates gene expression in both proliferating and differentiating progenitors along the neuronal lineage. Here, we used a cellular model of neurogenesis to investigate how Ascl1 interacts with the chromatin landscape to regulate gene expression when promoting neuronal diffe...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2015.02.025
更新日期：2015-03-10 00:00:00
abstract：:Spondweni virus (SPOV) is the flavivirus that is most closely related to Zika virus (ZIKV). Although SPOV causes sporadic human infections in Africa, recently it was found in Culex mosquitoes in Haiti. To investigate the pathogenic spectrum of SPOV, we developed infection models in mice. Although two SPOV strains fail...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2019.01.052
更新日期：2019-02-05 00:00:00
abstract：:Piwi-interacting RNAs (piRNAs), a class of 26- to 32-nt non-coding RNAs (ncRNAs), function in germline development, transposon silencing, and epigenetic regulation. We performed deep sequencing and annotation of untreated and periodate-treated small RNA cDNA libraries from human fetal and adult germline and reference ...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2015.09.030
更新日期：2015-10-27 00:00:00
abstract：:The macrophage NLRC4 inflammasome drives potent innate immune responses against Salmonella by eliciting caspase-1-dependent proinflammatory cytokine production (e.g., interleukin-1β [IL-1β]) and pyroptotic cell death. However, the potential contribution of other cell types to inflammasome-mediated host defense against...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2014.06.028
更新日期：2014-07-24 00:00:00
abstract：:The use of oligonucleotides to activate the splicing of selected exons is limited by a poor understanding of the mechanisms affected. A targeted bifunctional oligonucleotide enhancer of splicing (TOES) anneals to SMN2 exon 7 and carries an exonic splicing enhancer (ESE) sequence. We show that it stimulates splicing sp...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2014.08.051
更新日期：2014-10-09 00:00:00
abstract：:Learning critically depends on the ability to rapidly form and store non-overlapping representations of the external world. In line with their postulated role in episodic memory, hippocampal place cells can undergo a rapid reorganization of their firing fields upon contextual manipulations. To explore the mechanisms u...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2018.03.031
更新日期：2018-04-03 00:00:00
abstract：:Transport of RNAs to dendrites occurs in neuronal RNA granules, which allows local synthesis of specific proteins at active synapses on demand, thereby contributing to learning and memory. To gain insight into the machinery controlling dendritic mRNA localization and translation, we established a stringent protocol to...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2013.11.023
更新日期：2013-12-26 00:00:00
abstract：:Antiangiogenic therapy is commonly used in the clinic, but its beneficial effects are short-lived, leading to tumor relapse within months. Here, we found that the efficacy of angiogenic inhibitors targeting the VEGF/VEGFR pathway was dependent on induction of the angiostatic and immune-stimulatory chemokine CXCL14 in ...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2015.03.055
更新日期：2015-04-28 00:00:00
abstract：:Activation of phosphoinositide 3-kinase (PI3K) signaling plays a central role in regulating proliferation and survival of B cells. Here, we tested the hypothesis that B cell receptor (BCR)-mediated activation of PI3K induces the terminal differentiation factor Blimp-1 that interferes with proliferation and survival, t...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2018.06.035
更新日期：2018-07-10 00:00:00
abstract：:Fc receptor for IgM (FcμR)-deficient mice display dysregulated function of neutrophils, dendritic cells, and B cells. The relevance of FcμR to human T cells is still unknown. We show that FcμR is mostly stored inside the cell and that surface expression is tightly regulated. Decreased surface expression on T cells fro...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2019.02.024
更新日期：2019-03-05 00:00:00
