Notch2 Signaling Maintains NSC Quiescence in the Murine Ventricular-Subventricular Zone.

abstract：:CRISPR/Cas-based technologies have revolutionized genetic approaches to addressing a wide range of neurobiological questions. The ability of CRISPR/Cas to introduce mutations into target genes allows us to perform in vivo loss-of-function experiments without generating genetically engineered mice. However, the lack of...

journal_title：Cell reports

authors： Steinecke A,Kurabayashi N,Hayano Y,Ishino Y,Taniguchi H

更新日期：2019-07-09 00:00:00

abstract：:Quiescence is a fundamental property of adult stem cells. Recent evidence indicates that quiescence is not a default state but requires active signaling that prevents accidental or untimely activation of stem cells. The calcitonin receptor (CalcR) is critical for sustaining quiescence in muscle satellite (stem) cells ...

journal_title：Cell reports

authors： Zhang L,Noguchi YT,Nakayama H,Kaji T,Tsujikawa K,Ikemoto-Uezumi M,Uezumi A,Okada Y,Doi T,Watanabe S,Braun T,Fujio Y,Fukada SI

更新日期：2019-11-19 00:00:00

abstract：:Mucus separates gut-luminal microbes from the tissue. It is unclear how pathogens like Salmonella Typhimurium (S.Tm) can overcome this obstacle. Using live microscopy, we monitored S.Tm interactions with native murine gut explants and studied how mucus affects the infection. A dense inner mucus layer covers the distal...

journal_title：Cell reports

authors： Furter M,Sellin ME,Hansson GC,Hardt WD

更新日期：2019-05-28 00:00:00

abstract：:Transcription of developmental genes is controlled by multiple enhancers. Frequently, more than one enhancer can activate transcription from the same promoter in the same cells. How is regulatory information from multiple enhancers combined to determine the overall expression output? We measure nascent transcription d...

journal_title：Cell reports

authors： Scholes C,Biette KM,Harden TT,DePace AH

更新日期：2019-02-26 00:00:00

abstract：:The Piwi-piRNA pathway is well known for its germline function, yet its somatic role remains elusive. We show here that Piwi is required autonomously not only for germline stem cell (GSC) but also for somatic cyst stem cell (CySC) maintenance in the Drosophila testis. Reducing Piwi activity in the testis caused defect...

journal_title：Cell reports

authors： Gonzalez J,Qi H,Liu N,Lin H

更新日期：2015-07-07 00:00:00

abstract：:AMPK exerts prolongevity effects in diverse species; however, the tissue-specific mechanisms involved are poorly understood. Here, we show that upregulation of AMPK in the adult Drosophila nervous system induces autophagy both in the brain and also in the intestinal epithelium. Induction of autophagy is linked to impr...

journal_title：Cell reports

authors： Ulgherait M,Rana A,Rera M,Graniel J,Walker DW

更新日期：2014-09-25 00:00:00

abstract：:Whereas hundreds of cells in the mouse embryonic aorta transdifferentiate to hematopoietic cells, only very few establish hematopoietic stem cell (HSC) identity at a single time point. The Gata2 transcription factor is essential for HSC generation and function. In contrast to surface-marker-based cell isolation, Gata2...

journal_title：Cell reports

authors： Vink CS,Calero-Nieto FJ,Wang X,Maglitto A,Mariani SA,Jawaid W,Göttgens B,Dzierzak E

更新日期：2020-05-12 00:00:00

abstract：:Chronic exposure to stress is a major risk factor for neuropsychiatric disease, and elevated plasma corticosterone (CORT) correlates with reduced levels of both brain-derived neurotrophic factor (BDNF) and hippocampal neurogenesis. Precisely how these phenomena are linked, however, remains unclear. Using a cortico-hip...

journal_title：Cell reports

authors： Agasse F,Mendez-David I,Christaller W,Carpentier R,Braz BY,David DJ,Saudou F,Humbert S

更新日期：2020-07-07 00:00:00

abstract：:The mammalian target of rapamycin complex 1 (mTORC1) integrates signals important for cell growth, and its dysregulation in neural stem cells (NSCs) is implicated in several neurological disorders associated with abnormal neurogenesis and brain size. However, the function of mTORC1 on NSC self-renewal and the downstre...

journal_title：Cell reports

authors： Hartman NW,Lin TV,Zhang L,Paquelet GE,Feliciano DM,Bordey A

更新日期：2013-10-31 00:00:00

abstract：:CELF6 is a CELF-RNA-binding protein, and thus part of a protein family with roles in human disease; however, its mRNA targets in the brain are largely unknown. Using cross-linking immunoprecipitation and sequencing (CLIP-seq), we define its CNS targets, which are enriched for 3' UTRs in synaptic protein-coding genes. ...

journal_title：Cell reports

authors： Rieger MA,King DM,Crosby H,Liu Y,Cohen BA,Dougherty JD

更新日期：2020-12-22 00:00:00

abstract：:Epiblast cells in the early post-implantation stage mammalian embryo undergo a transition described as lineage priming before cell fate allocation, but signaling pathways acting upstream remain ill defined. Genetic studies demonstrate that Smad2/3 double-mutant mouse embryos die shortly after implantation. To learn mo...

journal_title：Cell reports

authors： Senft AD,Costello I,King HW,Mould AW,Bikoff EK,Robertson EJ

更新日期：2018-08-21 00:00:00

abstract：:Alzheimer's disease (AD) is the most common form of dementia, impairing cognitive and motor functions. One of the pathological hallmarks of AD is neuronal loss, which is not reflected in mouse models of AD. Therefore, the role of neuronal death is still uncertain. Here, we used a Drosophila AD model expressing a secre...

journal_title：Cell reports

authors： Coelho DS,Schwartz S,Merino MM,Hauert B,Topfel B,Tieche C,Rhiner C,Moreno E

更新日期：2018-12-26 00:00:00

abstract：:Neuregulin-1 (NRG1) gene variants are associated with increased genetic risk for schizophrenia. It is unclear whether risk haplotypes cause elevated or decreased expression of NRG1 in the brains of schizophrenia patients, given that both findings have been reported from autopsy studies. To study NRG1 functions in vivo...

journal_title：Cell reports

authors： Agarwal A,Zhang M,Trembak-Duff I,Unterbarnscheidt T,Radyushkin K,Dibaj P,Martins de Souza D,Boretius S,Brzózka MM,Steffens H,Berning S,Teng Z,Gummert MN,Tantra M,Guest PC,Willig KI,Frahm J,Hell SW,Bahn S,Rossner MJ

更新日期：2014-08-21 00:00:00

abstract：:In neurons, transmembrane proteins are targeted to dendrites in vesicles that traffic solely within the somatodendritic compartment. How these vesicles are retained within the somatodendritic domain is unknown. Here, we use a novel pulse-chase system, which allows synchronous release of exogenous transmembrane protein...

journal_title：Cell reports

authors： Al-Bassam S,Xu M,Wandless TJ,Arnold DB

更新日期：2012-07-26 00:00:00

abstract：:PARP1 is the main sensor of single- and double-strand breaks in DNA and, in building chains of poly(ADP-ribose), promotes the recruitment of many downstream signaling and effector proteins involved in the DNA damage response (DDR). We show a robust physical interaction between PARP1 and the replication fork protein TI...

journal_title：Cell reports

authors： Young LM,Marzio A,Perez-Duran P,Reid DA,Meredith DN,Roberti D,Star A,Rothenberg E,Ueberheide B,Pagano M

更新日期：2015-10-20 00:00:00

abstract：:Spinal cord longitudinal axons comprise some of the longest axons in our body. However, mechanisms that drive this extra long-distance axonal growth are largely unclear. We found that ascending axons of rapidly adapting (RA) mechanoreceptors closely abut a previously undescribed population of roof plate-derived radial...

journal_title：Cell reports

authors： Kridsada K,Niu J,Haldipur P,Wang Z,Ding L,Li JJ,Lindgren AG,Herrera E,Thomas GM,Chizhikov VV,Millen KJ,Luo W

更新日期：2018-06-05 00:00:00

abstract：:In mammals, the noncoding Xist RNA triggers transcriptional silencing of one of the two X chromosomes in female cells. Here, we report a genetic screen for silencing factors in X chromosome inactivation using haploid mouse embryonic stem cells (ESCs) that carry an engineered selectable reporter system. This system was...

journal_title：Cell reports

authors： Monfort A,Di Minin G,Postlmayr A,Freimann R,Arieti F,Thore S,Wutz A

更新日期：2015-07-28 00:00:00

abstract：:Nonalcoholic fatty liver disease is the most common chronic liver disorder in developed countries. Its pathogenesis is poorly understood, and therapeutic options are limited. Here, we show that SIRT7, an NAD(+)-dependent H3K18Ac deacetylase, functions at chromatin to suppress ER stress and prevent the development of f...

journal_title：Cell reports

authors： Shin J,He M,Liu Y,Paredes S,Villanova L,Brown K,Qiu X,Nabavi N,Mohrin M,Wojnoonski K,Li P,Cheng HL,Murphy AJ,Valenzuela DM,Luo H,Kapahi P,Krauss R,Mostoslavsky R,Yancopoulos GD,Alt FW,Chua KF,Chen D

更新日期：2013-11-14 00:00:00

abstract：:Changes in epigenetic states affect organismal homeostasis, including stress resistance. However, the mechanisms coordinating epigenetic states and systemic stress resistance remain largely unknown. Here, we identify the intestine-to-germline communication of epigenetic states, which intergenerationally enhances stres...

journal_title：Cell reports

authors： Nono M,Kishimoto S,Sato-Carlton A,Carlton PM,Nishida E,Uno M

更新日期：2020-03-10 00:00:00

abstract：:To ensure a successful infection, herpesviruses have developed elegant strategies to counterbalance the host anti-viral responses. Sterile alpha motif and HD domain 1 (SAMHD1) was recently identified as an intrinsic restriction factor for a variety of viruses. Aside from HIV-2 and the related simian immunodeficiency v...

journal_title：Cell reports

authors： Zhang K,Lv DW,Li R

更新日期：2019-07-09 00:00:00

abstract：:Antimitotic agents, including Taxol, disrupt microtubule dynamics and cause a protracted mitotic arrest and subsequent cell death. Despite the broad utility of these drugs in breast cancer and other tumor types, clinical response remains variable. Tumor-associated macrophages (TAMs) suppress the duration of Taxol-indu...

journal_title：Cell reports

authors： Olson OC,Kim H,Quail DF,Foley EA,Joyce JA

更新日期：2017-04-04 00:00:00

abstract：:Uveal melanoma (UM) is characterized by mutually exclusive activating mutations in GNAQ, GNA11, CYSLTR2, and PLCB4, four genes in a linear pathway to activation of PLCβ in almost all tumors and loss of BAP1 in the aggressive subset. We generated mice with melanocyte-specific expression of GNA11Q209L with and without h...

journal_title：Cell reports

authors： Moore AR,Ran L,Guan Y,Sher JJ,Hitchman TD,Zhang JQ,Hwang C,Walzak EG,Shoushtari AN,Monette S,Murali R,Wiesner T,Griewank KG,Chi P,Chen Y

更新日期：2018-02-27 00:00:00

abstract：:Despite recent progress in engineering native trimeric HIV-1 envelope glycoprotein (Env) mimics as vaccine candidates, Env trimers often induce vaccine-matched neutralizing antibody (NAb) responses. Understanding the specificities of autologous NAb responses and the underlying molecular mechanisms restricting the neut...

journal_title：Cell reports

authors： Lei L,Yang YR,Tran K,Wang Y,Chiang CI,Ozorowski G,Xiao Y,Ward AB,Wyatt RT,Li Y

更新日期：2019-04-09 00:00:00

abstract：:KRAS is one of the most commonly mutated oncogenes in human cancer. Mutant KRAS aberrantly regulates metabolic networks. However, the contribution of cellular metabolism to mutant KRAS tumorigenesis is not completely understood. We report that mutant KRAS regulates intracellular fatty acid metabolism through Acyl-coen...

journal_title：Cell reports

authors： Padanad MS,Konstantinidou G,Venkateswaran N,Melegari M,Rindhe S,Mitsche M,Yang C,Batten K,Huffman KE,Liu J,Tang X,Rodriguez-Canales J,Kalhor N,Shay JW,Minna JD,McDonald J,Wistuba II,DeBerardinis RJ,Scaglioni PP

更新日期：2016-08-09 00:00:00

abstract：:The MEF2 family of transcription factors restricts excitatory synapse number in an activity-dependent fashion during development, yet MEF2 has not been implicated in long-term synaptic depression (LTD), which is thought to initiate synapse elimination. Mutations in MEF2 pathways are implicated in autism spectrum disor...

journal_title：Cell reports

authors： Andzelm MM,Vanness D,Greenberg ME,Linden DJ

更新日期：2019-01-29 00:00:00

abstract：:Transcriptional analysis of brain tissue from people with molecularly defined causes of obesity may highlight disease mechanisms and therapeutic targets. We performed RNA sequencing of hypothalamus from individuals with Prader-Willi syndrome (PWS), a genetic obesity syndrome characterized by severe hyperphagia. We fou...

journal_title：Cell reports

authors： Bochukova EG,Lawler K,Croizier S,Keogh JM,Patel N,Strohbehn G,Lo KK,Humphrey J,Hokken-Koelega A,Damen L,Donze S,Bouret SG,Plagnol V,Farooqi IS

更新日期：2018-03-27 00:00:00

abstract：:Common fragile sites (CFSs) are genomic regions that display gaps and breaks in human metaphase chromosomes under replication stress and are often deleted in cancer cells. We studied an ∼300-bp subregion (Flex1) of human CFS FRA16D in yeast and found that it recapitulates characteristics of CFS fragility in human cell...

journal_title：Cell reports

authors： Kaushal S,Wollmuth CE,Das K,Hile SE,Regan SB,Barnes RP,Haouzi A,Lee SM,House NCM,Guyumdzhyan M,Eckert KA,Freudenreich CH

更新日期：2019-04-23 00:00:00

abstract：:Macrophages exist predominantly in two distinct states, G0 and a G1-like state that is accompanied by phosphorylation of SAMHD1 at T592. Here, we demonstrate that Toll-like receptor 4 (TLR4) activation can potently induce G0 arrest and SAMHD1 antiretroviral activity by an interferon (IFN)-independent pathway. This pat...

journal_title：Cell reports

authors： Mlcochova P,Winstone H,Zuliani-Alvarez L,Gupta RK

更新日期：2020-03-24 00:00:00

abstract：:How ubiquitous transcription factors (TFs) coordinate temporal inputs from broadly expressed epigenetic factors to control cell fate remains poorly understood. Here, we uncover a molecular relationship between p53, an abundant embryonic TF, and WDR5, an essential member of the MLL chromatin modifying complex, that reg...

journal_title：Cell reports

authors： Li Q,Mao F,Zhou B,Huang Y,Zou Z,denDekker AD,Xu J,Hou S,Liu J,Dou Y,Rao RC

更新日期：2020-01-14 00:00:00

abstract：:Embryonic cells transcriptionally repress the expression of endogenous and exogenous retroelements. Trim28, a key player in this silencing, is known to act in a large DNA-bound complex, but the other components of the complex are not fully characterized. Here, we show that the zinc finger protein Yin Yang 1 (YY1) is o...

journal_title：Cell reports

authors： Schlesinger S,Lee AH,Wang GZ,Green L,Goff SP

更新日期：2013-07-11 00:00:00