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Functional Access to Neuron Subclasses in Rodent and Primate Forebrain.

Abstract：

:Viral vectors enable foreign proteins to be expressed in brains of non-genetic species, including non-human primates. However, viruses targeting specific neuron classes have proved elusive. Here we describe viral promoters and strategies for accessing GABAergic interneurons and their molecularly defined subsets in the rodent and primate. Using a set intersection approach, which relies on two co-active promoters, we can restrict heterologous protein expression to cortical and hippocampal somatostatin-positive and parvalbumin-positive interneurons. With an orthogonal set difference method, we can enrich for subclasses of neuropeptide-Y-positive GABAergic interneurons by effectively subtracting the expression pattern of one promoter from that of another. These methods harness the complexity of gene expression patterns in the brain and significantly expand the number of genetically tractable neuron classes across mammals.

journal_name

Cell Rep

journal_title

Cell reports

authors

Mehta P,Kreeger L,Wylie DC,Pattadkal JJ,Lusignan T,Davis MJ,Turi GF,Li WK,Whitmire MP,Chen Y,Kajs BL,Seidemann E,Priebe NJ,Losonczy A,Zemelman BV

doi

10.1016/j.celrep.2019.02.011

subject

Has Abstract

pub_date

2019-03-05 00:00:00

pages

2818-2832.e8

issue

10

issn

2211-1247

pii

S2211-1247(19)30173-1

journal_volume

26

pub_type

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