Fumarate Hydratase Deletion in Pancreatic β Cells Leads to Progressive Diabetes.

abstract：:Brain function is compromised in myotonic dystrophy type 1 (DM1), but the underlying mechanisms are not fully understood. To gain insight into the cellular and molecular pathways primarily affected, we studied a mouse model of DM1 and brains of adult patients. We found pronounced RNA toxicity in the Bergmann glia of t...

journal_title：Cell reports

authors： Sicot G,Servais L,Dinca DM,Leroy A,Prigogine C,Medja F,Braz SO,Huguet-Lachon A,Chhuon C,Nicole A,Gueriba N,Oliveira R,Dan B,Furling D,Swanson MS,Guerrera IC,Cheron G,Gourdon G,Gomes-Pereira M

更新日期：2017-06-27 00:00:00

abstract：:Transcriptome analyses have revealed that convergent gene transcription can produce many 3'-overlapping mRNAs in diverse organisms. Few studies have examined the fate of 3'-complementary mRNAs in double-stranded RNA-dependent nuclear phenomena, and nothing is known about the cytoplasmic destiny of 3'-overlapping messe...

journal_title：Cell reports

authors： Sinturel F,Navickas A,Wery M,Descrimes M,Morillon A,Torchet C,Benard L

更新日期：2015-09-22 00:00:00

abstract：:Engrailed homeoproteins are expressed in adult dopaminergic neurons of the substantia nigra. In Engrailed1 heterozygous mice, these neurons start dying at 6 weeks, are more sensitive to oxidative stress, and progressively develop traits similar to those observed following an acute and strong oxidative stress inflected...

journal_title：Cell reports

authors： Rekaik H,Blaudin de Thé FX,Fuchs J,Massiani-Beaudoin O,Prochiantz A,Joshi RL

更新日期：2015-10-13 00:00:00

abstract：:Cell growth is coupled to cell-cycle progression in mitotically proliferating mammalian cells, but the underlying molecular mechanisms are not well understood. CyclinD-Cdk4/6 is known to phosphorylate RB to promote S-phase entry, but recent work suggests they have additional functions. We show here that CyclinD-Cdk4/6...

journal_title：Cell reports

authors： Romero-Pozuelo J,Figlia G,Kaya O,Martin-Villalba A,Teleman AA

更新日期：2020-04-14 00:00:00

abstract：:In the presynaptic terminal, the magnitude and location of Ca2+ entry through voltage-gated Ca2+ channels (VGCCs) regulate the efficacy of neurotransmitter release. However, how presynaptic active zone proteins control mammalian VGCC levels and organization is unclear. To address this, we deleted the CAST/ELKS protein...

journal_title：Cell reports

authors： Dong W,Radulovic T,Goral RO,Thomas C,Suarez Montesinos M,Guerrero-Given D,Hagiwara A,Putzke T,Hida Y,Abe M,Sakimura K,Kamasawa N,Ohtsuka T,Young SM Jr

更新日期：2018-07-10 00:00:00

abstract：:RNAi screens have implicated hundreds of host proteins as HIV-1 dependency factors (HDFs). While informative, these early studies overlap poorly due to false positives and false negatives. To ameliorate these issues, we combined information from the existing HDF screens together with new screens performed with multipl...

journal_title：Cell reports

authors： Zhu J,Davoli T,Perriera JM,Chin CR,Gaiha GD,John SP,Sigiollot FD,Gao G,Xu Q,Qu H,Pertel T,Sims JS,Smith JA,Baker RE,Maranda L,Ng A,Elledge SJ,Brass AL

更新日期：2014-10-23 00:00:00

abstract：:Pathogens trigger T cells to express distinct sets of effector proteins. To better understand the molecular mechanisms that drive functional specification, we used high-resolution mass spectrometry and label-free protein quantification to measure proteomic differences between the seven largest circulating human CD8+ T...

journal_title：Cell reports

authors： van Aalderen MC,van den Biggelaar M,Remmerswaal EBM,van Alphen FPJ,Meijer AB,Ten Berge IJM,van Lier RAW

更新日期：2017-05-02 00:00:00

abstract：:Haplo-insufficiency of telomerase genes in humans leads to telomere syndromes such as dyskeratosis congenital and idiopathic pulmonary fibrosis. Generation of pluripotent stem cells from telomerase haplo-insufficient donor cells would provide unique opportunities toward the realization of patient-specific stem cell th...

journal_title：Cell reports

authors： Sung LY,Chang WF,Zhang Q,Liu CC,Liou JY,Chang CC,Ou-Yang H,Guo R,Fu H,Cheng WTK,Ding ST,Chen CM,Okuka M,Keefe DL,Chen YE,Liu L,Xu J

更新日期：2014-12-11 00:00:00

abstract：:After implantation, pluripotent epiblasts are converted to embryonic ectoderm through cell-cell interactions that significantly change the transcriptional and epigenetic networks. An entrée to understanding this vital developmental transition is the t(w5) mutation of the mouse t complex. This mutation produces highly ...

journal_title：Cell reports

authors： Sugimoto M,Kondo M,Hirose M,Suzuki M,Mekada K,Abe T,Kiyonari H,Ogura A,Takagi N,Artzt K,Abe K

更新日期：2012-11-29 00:00:00

abstract：:Plant glutamate receptor homologs (GLRs) have long been proposed to function as ligand-gated Ca2+ channels, but no in planta evidence has been provided. Here, we present genetic evidence that Arabidopsis GLR3.1 and GLR3.5 form Ca2+ channels activated by L-methionine (L-Met) at physiological concentrations and regulate...

journal_title：Cell reports

authors： Kong D,Hu HC,Okuma E,Lee Y,Lee HS,Munemasa S,Cho D,Ju C,Pedoeim L,Rodriguez B,Wang J,Im W,Murata Y,Pei ZM,Kwak JM

更新日期：2016-12-06 00:00:00

abstract：:The root stem cell niche, which is composed of four mitotically inactive quiescent center (QC) cells and the surrounding actively divided stem cells in Arabidopsis, is critical for growth and root development. Here, we demonstrate that the Arabidopsis prohibitin protein PHB3 is required for the maintenance of root ste...

journal_title：Cell reports

authors： Kong X,Tian H,Yu Q,Zhang F,Wang R,Gao S,Xu W,Liu J,Shani E,Fu C,Zhou G,Zhang L,Zhang X,Ding Z

更新日期：2018-01-30 00:00:00

abstract：:Bat cells and tissue have elevated basal expression levels of antiviral genes commonly associated with interferon alpha (IFNα) signaling. Here, we show Interferon Regulatory Factor 1 (IRF1), 3, and 7 levels are elevated in most bat tissues and that, basally, IRFs contribute to the expression of type I IFN ligands and ...

journal_title：Cell reports

authors： Irving AT,Zhang Q,Kong PS,Luko K,Rozario P,Wen M,Zhu F,Zhou P,Ng JHJ,Sobota RM,Wang LF

更新日期：2020-11-03 00:00:00

abstract：:Large-scale, cooperative rearrangements underlie the functions of RNA in RNA-protein machines and gene regulation. To understand how such rearrangements are orchestrated, we used high-throughput chemical footprinting to dissect a seemingly concerted rearrangement in P5abc RNA, a paradigm of RNA folding studies. With m...

journal_title：Cell reports

authors： Gracia B,Al-Hashimi HM,Bisaria N,Das R,Herschlag D,Russell R

更新日期：2018-03-20 00:00:00

abstract：:Physicians have observed that surgical wounds in the elderly heal with thinner scars than wounds in young patients. Understanding this phenomenon may reveal strategies for promoting scarless wound repair. We show that full-thickness skin wounds in aged but not young mice fully regenerate. Exposure of aged animals to b...

journal_title：Cell reports

authors： Nishiguchi MA,Spencer CA,Leung DH,Leung TH

更新日期：2018-09-25 00:00:00

abstract：:Embryonic cells transcriptionally repress the expression of endogenous and exogenous retroelements. Trim28, a key player in this silencing, is known to act in a large DNA-bound complex, but the other components of the complex are not fully characterized. Here, we show that the zinc finger protein Yin Yang 1 (YY1) is o...

journal_title：Cell reports

authors： Schlesinger S,Lee AH,Wang GZ,Green L,Goff SP

更新日期：2013-07-11 00:00:00

abstract：:Senescence is a cellular response preventing tumorigenesis. The Ras oncogene is frequently activated or mutated in human cancers, but Ras activation is insufficient to transform primary cells. In a search for cooperating oncogenes, we identify the lysine demethylase JMJD2A/KDM4A. We show that JMJD2A functions as a neg...

journal_title：Cell reports

authors： Mallette FA,Richard S

更新日期：2012-11-29 00:00:00

abstract：:Sustained canonical Wnt signaling requires the inhibition of glycogen synthase kinase 3 (GSK3) activity by sequestration of GSK3 inside multivesicular endosomes (MVEs). Here, we show that Wnt signaling is increased by the lysosomal inhibitor chloroquine, which causes accumulation of MVEs. A similar MVE expansion and i...

journal_title：Cell reports

authors： Dobrowolski R,Vick P,Ploper D,Gumper I,Snitkin H,Sabatini DD,De Robertis EM

更新日期：2012-11-29 00:00:00

abstract：:Alcohol produces both stimulant and sedative effects in humans and rodents. In humans, alcohol abuse disorder is associated with a higher stimulant and lower sedative responses to alcohol. Here, we show that this association is conserved in mice and demonstrate a causal link with another liability factor: low expressi...

journal_title：Cell reports

authors： Bocarsly ME,da Silva E Silva D,Kolb V,Luderman KD,Shashikiran S,Rubinstein M,Sibley DR,Dobbs LK,Alvarez VA

更新日期：2019-10-29 00:00:00

abstract：:Organismal death is a process of systemic collapse whose mechanisms are less well understood than those of cell death. We previously reported that death in C. elegans is accompanied by a calcium-propagated wave of intestinal necrosis, marked by a wave of blue autofluorescence (death fluorescence). Here, we describe an...

journal_title：Cell reports

authors： Galimov ER,Pryor RE,Poole SE,Benedetto A,Pincus Z,Gems D

更新日期：2018-03-06 00:00:00

abstract：:Dendritic cells (DCs) and macrophages (Mϕs) share close developmental pathways and functional features, leading to blurring of the boundaries between these two cell lineages. However, a deeper understanding of DC and Mϕ ontogeny and more refined phenotypic and functional characterizations have helped to delineate pre-...

journal_title：Cell reports

authors： Sheng J,Chen Q,Soncin I,Ng SL,Karjalainen K,Ruedl C

更新日期：2017-10-31 00:00:00

abstract：:Clericuzio-type poikiloderma with neutropenia (PN) is a rare genodermatosis associated with mutations in the C16orf57 gene, which codes for the uncharacterized protein hMpn1. We show here that, in both fission yeasts and humans, Mpn1 processes the spliceosomal U6 small nuclear RNA (snRNA) posttranscriptionally. In Mpn...

journal_title：Cell reports

authors： Shchepachev V,Wischnewski H,Missiaglia E,Soneson C,Azzalin CM

更新日期：2012-10-25 00:00:00

abstract：:During postnatal development, cerebellar climbing fibers alter their innervation strengths onto supernumerary Purkinje cell targets, generating a one-to-few connectivity pattern in adulthood. To get insight about the processes responsible for this remapping, we reconstructed serial electron microscopy datasets from mi...

journal_title：Cell reports

authors： Wilson AM,Schalek R,Suissa-Peleg A,Jones TR,Knowles-Barley S,Pfister H,Lichtman JW

更新日期：2019-11-26 00:00:00

abstract：:T helper-17 (Th17) cells are associated with inflammatory disorders and cancer. We report that environmental conditions resulting in cellular stress, such as low oxygen, glucose, and isotonic stress, particularly enhance the generation of Th17 cells. Pharmacological inhibition of cell stress reduces Th17 cell differen...

journal_title：Cell reports

authors： Brucklacher-Waldert V,Ferreira C,Stebegg M,Fesneau O,Innocentin S,Marie JC,Veldhoen M

更新日期：2017-06-13 00:00:00

abstract：:The subgranular zone (SGZ) of the adult hippocampus contains a pool of quiescent neural progenitor cells (QNPs) that are capable of entering the cell cycle and producing newborn neurons. The mechanisms that control the timing and extent of adult neurogenesis are not well understood. Here, we show that QNPs of the adul...

journal_title：Cell reports

authors： Bouchard-Cannon P,Mendoza-Viveros L,Yuen A,Kærn M,Cheng HY

更新日期：2013-11-27 00:00:00

abstract：:DNA polymerase ζ (Polζ) is specialized for the extension step of translesion DNA synthesis (TLS). Despite its central role in maintaining genome integrity, little is known about its overall architecture. Initially identified as a heterodimer of the catalytic subunit Rev3 and the accessory subunit Rev7, yeast Polζ has ...

journal_title：Cell reports

authors： Gómez-Llorente Y,Malik R,Jain R,Choudhury JR,Johnson RE,Prakash L,Prakash S,Ubarretxena-Belandia I,Aggarwal AK

更新日期：2013-10-17 00:00:00

abstract：:A central paradigm in the field of lymphocyte biology asserts that replicatively senescent memory T cells express the carbohydrate epitope CD57. These cells nonetheless accumulate with age and expand numerically in response to persistent antigenic stimulation. Here, we use in vivo deuterium labeling and ex vivo analys...

journal_title：Cell reports

authors： Ahmed R,Miners KL,Lahoz-Beneytez J,Jones RE,Roger L,Baboonian C,Zhang Y,Wang ECY,Hellerstein MK,McCune JM,Baird DM,Price DA,Macallan DC,Asquith B,Ladell K

更新日期：2020-12-15 00:00:00

abstract：:Oct4 is an essential regulator of pluripotency in vivo and in vitro in embryonic stem cells, as well as a key mediator of the reprogramming of somatic cells into induced pluripotent stem cells. It is not known whether activation and/or repression of specific genes by Oct4 is relevant to these functions. Here, we show ...

journal_title：Cell reports

authors： Hammachi F,Morrison GM,Sharov AA,Livigni A,Narayan S,Papapetrou EP,O'Malley J,Kaji K,Ko MS,Ptashne M,Brickman JM

更新日期：2012-02-23 00:00:00

abstract：:The JAK/STAT1 pathway is generally activated by cytokines, providing essential antiviral defense. Here, we identify that STAT1 activation is independent of cytokines and JAKs at the early infection stage of some viruses, including influenza A virus (IAV). Instead, STAT1 is activated mainly through spleen tyrosine kina...

journal_title：Cell reports

authors： Liu S,Liao Y,Chen B,Chen Y,Yu Z,Wei H,Zhang L,Huang S,Rothman PB,Gao GF,Chen JL

更新日期：2021-01-19 00:00:00

abstract：:Tumor suppressor p53 regulates transcription of stress-response genes. Many p53 targets remain undiscovered because of uncertainty as to where p53 binds in the genome and the fact that few genes reside near p53-bound recognition elements (REs). Using chromatin immunoprecipitation followed by exonuclease treatment (ChI...

journal_title：Cell reports

authors： Chang GS,Chen XA,Park B,Rhee HS,Li P,Han KH,Mishra T,Chan-Salis KY,Li Y,Hardison RC,Wang Y,Pugh BF

更新日期：2014-07-24 00:00:00

abstract：:STAT5, a member of the family of signal transducers and activators of transcription, senses cytokines and controls the biology of cell lineages, including mammary, liver, and T cells. Here, we show that STAT5 activates lineage-specific and widely expressed genes through different mechanisms. STAT5 preferentially binds...

journal_title：Cell reports

authors： Zeng X,Willi M,Shin HY,Hennighausen L,Wang C

更新日期：2016-12-20 00:00:00