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Telomere elongation and naive pluripotent stem cells achieved from telomerase haplo-insufficient cells by somatic cell nuclear transfer.

Abstract：

:Haplo-insufficiency of telomerase genes in humans leads to telomere syndromes such as dyskeratosis congenital and idiopathic pulmonary fibrosis. Generation of pluripotent stem cells from telomerase haplo-insufficient donor cells would provide unique opportunities toward the realization of patient-specific stem cell therapies. Recently, pluripotent human embryonic stem cells (ntESCs) have been efficiently achieved by somatic cell nuclear transfer (SCNT). We tested the hypothesis that SCNT could effectively elongate shortening telomeres of telomerase haplo-insufficient cells in the ntESCs with relevant mouse models. Indeed, telomeres of telomerase haplo-insufficient (Terc(+/-)) mouse cells are elongated in ntESCs. Moreover, ntESCs derived from Terc(+/-) cells exhibit naive pluripotency as evidenced by generation of Terc(+/-) ntESC clone pups by tetraploid embryo complementation, the most stringent test of naive pluripotency. These data suggest that SCNT could offer a powerful tool to reprogram telomeres and to discover the factors for robust restoration of telomeres and pluripotency of telomerase haplo-insufficient somatic cells.

journal_name

Cell Rep

journal_title

Cell reports

authors

Sung LY,Chang WF,Zhang Q,Liu CC,Liou JY,Chang CC,Ou-Yang H,Guo R,Fu H,Cheng WTK,Ding ST,Chen CM,Okuka M,Keefe DL,Chen YE,Liu L,Xu J

doi

10.1016/j.celrep.2014.10.052

subject

Has Abstract

pub_date

2014-12-11 00:00:00

pages

1603-1609

issue

5

issn

2211-1247

pii

S2211-1247(14)00921-8

journal_volume

9

pub_type

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