Abstract:
:Megakaryocytes (MKs) come from a complex process of hematopoietic progenitor maturation within the bone marrow that gives rise to de novo circulating platelets. Bone marrow microenvironment contains a large number of adipocytes with a still ill-defined role. This study aims to analyze the influence of adipocytes and increased medullar adiposity in megakaryopoiesis. An in vivo increased medullar adiposity in mice caused by high-fat-diet-induced obesity is associated to an enhanced MK maturation and proplatelet formation. In vitro co-culture of adipocytes with bone marrow hematopoietic progenitors shows that delipidation of adipocytes directly supports MK maturation by enhancing polyploidization, amplifying the demarcation membrane system, and accelerating proplatelet formation. This direct crosstalk between adipocytes and MKs occurs through adipocyte fatty acid transfer to MKs involving CD36 to reinforce megakaryocytic maturation. Thus, these findings unveil an influence of adiposity on MK homeostasis based on a dialogue between adipocytes and MKs.
journal_name
Cell Repjournal_title
Cell reportsauthors
Valet C,Batut A,Vauclard A,Dortignac A,Bellio M,Payrastre B,Valet P,Severin Sdoi
10.1016/j.celrep.2020.107875subject
Has Abstractpub_date
2020-07-07 00:00:00pages
107875issue
1issn
2211-1247pii
S2211-1247(20)30856-1journal_volume
32pub_type
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