Plasma Membrane Furrows Control Plasticity of ER-PM Contacts.

Abstract:

:The plasma membrane (PM) forms extensive close junctions with the cortical endoplasmic reticulum (cER) in many cell types, ranging from yeast to mammals. How cells modulate structural plasticity of ER-PM contacts to accommodate space-demanding cortical events is largely unknown. Here, we report a role for eisosome-driven PM furrows in regulating ER-PM contact plasticity in fission yeast. We demonstrate that eisosome-coated PM invaginations function to stabilize local ER-PM contacts and attenuate cER remodeling dynamics through electrostatic Scs2-Pil1 interactions. We also identify divergent roles of ER-shaping proteins in controlling cER remodeling capacity and ER-PM contact plasticity. Furthermore, we show that eisosome organization is responsive to PM tension variations during active PM remodeling, which may enable adaptive control of ER-PM contact plasticity to potentially coordinate with space-demanding PM events. We thus propose a cellular strategy of modulating membrane contact plasticity by deploying sensory elements at contact sites.

journal_name

Cell Rep

journal_title

Cell reports

authors

Ng AQE,Ng AYE,Zhang D

doi

10.1016/j.celrep.2019.12.098

subject

Has Abstract

pub_date

2020-02-04 00:00:00

pages

1434-1446.e7

issue

5

issn

2211-1247

pii

S2211-1247(19)31763-2

journal_volume

30

pub_type

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