Abstract：
:Interest in manipulating the gut microbiota to treat disease has led to a need for understanding how organisms can establish themselves when introduced into a host with an intact microbial community. Here, we employ the concept of orthogonal niche engineering: a resource typically absent from the diet, seaweed, creates a customized niche for an introduced organism. In the short term, co-introduction of this resource at 1% in the diet along with an organism with exclusive access to this resource, Bacteroides plebeius DSM 17135, enables it to colonize at a median abundance of 1% and frequently up to 10 or more percent, both on pulsed and constant seaweed diets. In a two-month follow-up after the initial treatment period, B. plebeius stops responding to seaweed in mice initially on the constant seaweed diet, suggesting treatment regime will affect controllability. These results offer potential for diet-based intervention to introduce and control target organisms.
journal_name
Cell Repjournal_title
Cell reportsauthors
Kearney SM,Gibbons SM,Erdman SE,Alm EJdoi
10.1016/j.celrep.2018.07.032subject
Has Abstractpub_date
2018-08-14 00:00:00pages
1842-1851issue
7issn
2211-1247pii
S2211-1247(18)31122-7journal_volume
24pub_type
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