Abstract：
:The corpus callosum is the major axon tract that connects and integrates neural activity between the two cerebral hemispheres. Although ∼1:4,000 children are born with developmental absence of the corpus callosum, the primary etiology of this condition remains unknown. Here, we demonstrate that midline crossing of callosal axons is dependent upon the prior remodeling and degradation of the intervening interhemispheric fissure. This remodeling event is initiated by astroglia on either side of the interhemispheric fissure, which intercalate with one another and degrade the intervening leptomeninges. Callosal axons then preferentially extend over these specialized astroglial cells to cross the midline. A key regulatory step in interhemispheric remodeling is the differentiation of these astroglia from radial glia, which is initiated by Fgf8 signaling to downstream Nfi transcription factors. Crucially, our findings from human neuroimaging studies reveal that developmental defects in interhemispheric remodeling are likely to be a primary etiology underlying human callosal agenesis.
journal_name
Cell Repjournal_title
Cell reportsauthors
Gobius I,Morcom L,Suárez R,Bunt J,Bukshpun P,Reardon W,Dobyns WB,Rubenstein JL,Barkovich AJ,Sherr EH,Richards LJdoi
10.1016/j.celrep.2016.09.033subject
Has Abstractpub_date
2016-10-11 00:00:00pages
735-747issue
3issn
2211-1247pii
S2211-1247(16)31255-4journal_volume
17pub_type
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