An Endoplasmic Reticulum ATPase Safeguards Endoplasmic Reticulum Identity by Removing Ectopically Localized Mitochondrial Proteins.

abstract：:Long believed to be a byproduct of malignant transformation, reprogramming of cellular metabolism is now recognized as a driving force in tumorigenesis. In clear cell renal cell carcinoma (ccRCC), frequent activation of HIF signaling induces a metabolic switch that promotes tumorigenesis. Here, we demonstrate that PGC...

journal_title：Cell reports

authors： LaGory EL,Wu C,Taniguchi CM,Ding CC,Chi JT,von Eyben R,Scott DA,Richardson AD,Giaccia AJ

更新日期：2015-07-07 00:00:00

abstract：:In higher vertebrates, cephalic neural crest cells (NCCs) form craniofacial skeleton by differentiating into chondrocytes and osteoblasts. A subpopulation of cephalic NCCs, cardiac NCCs (CNCCs), migrates to the heart. However, CNCCs mostly do not yield skeletogenic derivatives, and the molecular mechanisms of this fat...

journal_title：Cell reports

authors： Arai HN,Sato F,Yamamoto T,Woltjen K,Kiyonari H,Yoshimoto Y,Shukunami C,Akiyama H,Kist R,Sehara-Fujisawa A

更新日期：2019-10-15 00:00:00

abstract：:Dentate gyrus (DG) development requires specification of granule cell (GC) progenitors in the hippocampal neuroepithelium, as well as their proliferation and migration into the primordial DG. We identify the Plexin family members Plxna2 and Plxna4 as important regulators of DG development. Distribution of immature GCs...

journal_title：Cell reports

authors： Zhao XF,Kohen R,Parent R,Duan Y,Fisher GL,Korn MJ,Ji L,Wan G,Jin J,Püschel AW,Dolan DF,Parent JM,Corfas G,Murphy GG,Giger RJ

更新日期：2018-01-09 00:00:00

abstract：:Effector, but not naïve, T cells are activated by toll-like receptor-2 (TLR2) stimulation, leading to cytokine production and proliferation. We found that the differential response is attributable to the lack of expression of the adaptor protein TIRAP in naive T cells. TIRAP expression is induced upon T-cell receptor ...

journal_title：Cell reports

authors： Imanishi T,Unno M,Kobayashi W,Yoneda N,Akira S,Saito T

更新日期：2020-07-21 00:00:00

abstract：:Parsing diverse nerve cells into biological types is necessary for understanding neural circuit organization. Morphology is an intuitive criterion for neuronal classification and a proxy of connectivity, but morphological diversity and variability often preclude resolving the granularity of neuron types. Combining gen...

journal_title：Cell reports

authors： Wang X,Tucciarone J,Jiang S,Yin F,Wang BS,Wang D,Jia Y,Jia X,Li Y,Yang T,Xu Z,Akram MA,Wang Y,Zeng S,Ascoli GA,Mitra P,Gong H,Luo Q,Huang ZJ

更新日期：2019-03-12 00:00:00

abstract：:The mechanisms dictating whether a cell proliferates or differentiates have undergone intense scrutiny, but they remain poorly understood. Here, we report that UPF1, a central component in the nonsense-mediated RNA decay (NMD) pathway, plays a key role in this decision by promoting the proliferative, undifferentiated ...

journal_title：Cell reports

authors： Lou CH,Shao A,Shum EY,Espinoza JL,Huang L,Karam R,Wilkinson MF

更新日期：2014-02-27 00:00:00

abstract：:Despite the comprehensive knowledge on odor coding, our understanding of the relationship between sensory input and behavioral output in Drosophila remains weak. Here, we measure the behavioral responses generated by larval and adult flies in response to 34 fruit odors and find that larval preference for fruit odors d...

journal_title：Cell reports

authors： Dweck HKM,Ebrahim SAM,Retzke T,Grabe V,Weißflog J,Svatoš A,Hansson BS,Knaden M

更新日期：2018-05-22 00:00:00

abstract：:Several pattern-recognition receptors sense HIV-1 replication products and induce type I interferon (IFN-I) production under specific experimental conditions. However, it is thought that viral sensing and IFN induction are virtually absent in the main target cells of HIV-1 in vivo. Here, we show that activated CD4+ T ...

journal_title：Cell reports

authors： Vermeire J,Roesch F,Sauter D,Rua R,Hotter D,Van Nuffel A,Vanderstraeten H,Naessens E,Iannucci V,Landi A,Witkowski W,Baeyens A,Kirchhoff F,Verhasselt B

更新日期：2016-10-04 00:00:00

abstract：:Animal nervous systems remodel following stress. Although global stress-dependent changes are well documented, contributions of individual neuron remodeling events to animal behavior modification are challenging to study. In response to environmental insults, C. elegans become stress-resistant dauers. Dauer entry indu...

journal_title：Cell reports

authors： Lee IH,Procko C,Lu Y,Shaham S

更新日期：2021-01-12 00:00:00

abstract：:Herein, we demonstrate that HCMV miR-UL112-5p targets ERAP1, thereby inhibiting the processing and presentation of the HCMV pp65495-503 peptide to specific CTLs. In addition, we show that the rs17481334 G variant, naturally occurring in the ERAP1 3' UTR, preserves ERAP1 from miR-UL112-5p-mediated degradation. Specific...

journal_title：Cell reports

authors： Romania P,Cifaldi L,Pignoloni B,Starc N,D'Alicandro V,Melaiu O,Li Pira G,Giorda E,Carrozzo R,Bergvall M,Bergström T,Alfredsson L,Olsson T,Kockum I,Seppälä I,Lehtimäki T,Hurme MA,Hengel H,Santoni A,Cerboni C,Locate

更新日期：2017-07-25 00:00:00

abstract：:Fibrillarin (FBL) is a dual-function nucleolar protein that catalyzes 2'-O methylation of pre-rRNA and methylation of histone H2A at glutamine 104 (H2AQ104me). The mechanisms that regulate FBL activity are unexplored. Here, we show that FBL is acetylated at several lysine residues by the acetyltransferase CBP and deac...

journal_title：Cell reports

authors： Iyer-Bierhoff A,Krogh N,Tessarz P,Ruppert T,Nielsen H,Grummt I

更新日期：2018-12-11 00:00:00

abstract：:Nono is a component of the para-speckle, which stores and processes RNA. Mouse embryonic stem cells (mESCs) lack para-speckles, leaving the function of Nono in mESCs unclear. Here, we find that Nono functions as a chromatin regulator cooperating with Erk to regulate mESC pluripotency. We report that Nono loss results ...

journal_title：Cell reports

authors： Ma C,Karwacki-Neisius V,Tang H,Li W,Shi Z,Hu H,Xu W,Wang Z,Kong L,Lv R,Fan Z,Zhou W,Yang P,Wu F,Diao J,Tan L,Shi YG,Lan F,Shi Y

更新日期：2016-10-18 00:00:00

abstract：:Lipoprotein cholesterol is delivered to the limiting membrane of late endosomes/lysosomes (LELs) by Niemann-Pick C1 (NPC1). However, the mechanism of cholesterol transport from LELs to the endoplasmic reticulum (ER) is poorly characterized. We report that oxysterol-binding protein-related protein 1L (ORP1L) is necessa...

journal_title：Cell reports

authors： Zhao K,Ridgway ND

更新日期：2017-05-30 00:00:00

abstract：:The anorectic and weight-suppressive effects of growth differentiation factor-15 (GDF15) are attracting considerable attention for treating obesity. Current experiments in rats investigate whether GDF15 induces an aversive visceral malaise-based state that mediates its acute anorectic effect and, through aversion cond...

journal_title：Cell reports

authors： Borner T,Wald HS,Ghidewon MY,Zhang B,Wu Z,De Jonghe BC,Breen D,Grill HJ

更新日期：2020-04-21 00:00:00

abstract：:The serine/threonine protein phosphatase 5 (PP5) regulates multiple cellular signaling networks. A number of cellular factors, including heat shock protein 90 (Hsp90), promote the activation of PP5. However, it is unclear whether post-translational modifications also influence PP5 phosphatase activity. Here, we show a...

journal_title：Cell reports

authors： Dushukyan N,Dunn DM,Sager RA,Woodford MR,Loiselle DR,Daneshvar M,Baker-Williams AJ,Chisholm JD,Truman AW,Vaughan CK,Haystead TA,Bratslavsky G,Bourboulia D,Mollapour M

更新日期：2017-11-14 00:00:00

abstract：:Embryonic stem cells (ESCs) hold promise for the treatment of many medical conditions; however, their utility is limited by immune rejection. The objective of our study is to establish tolerance or promote engraftment of transplanted ESCs as well as mature cell populations derived from ESCs. Luciferase (luc(+))-expres...

journal_title：Cell reports

authors： Pan Y,Leveson-Gower DB,de Almeida PE,Pierini A,Baker J,Florek M,Nishikii H,Kim BS,Ke R,Wu JC,Negrin RS

更新日期：2015-03-24 00:00:00

abstract：:Humoral immune responses are tailored to the invading pathogen through regulation of key transcription factors and their networks. This is critical to establishing effective antibody-mediated responses, yet it is unknown how B cells integrate pathogen-induced signals to drive or suppress transcriptional programs speci...

journal_title：Cell reports

authors： Piovesan D,Tempany J,Di Pietro A,Baas I,Yiannis C,O'Donnell K,Chen Y,Peperzak V,Belz GT,Mackay CR,Smyth GK,Groom JR,Tarlinton DM,Good-Jacobson KL

更新日期：2017-04-18 00:00:00

abstract：:Cytokinesis, the final step of cell division, begins with the formation of a cleavage furrow. How the mitotic spindle specifies the furrow at the equator in animal cells remains unknown. Current models propose that the concentration of the RhoGEF ECT2 at the spindle midzone and the equatorial plasma membrane directs f...

journal_title：Cell reports

authors： Kotýnková K,Su KC,West SC,Petronczki M

更新日期：2016-12-06 00:00:00

abstract：:Simultaneous expression of Oct4, Klf4, Sox2, and cMyc induces pluripotency in somatic cells (iPSCs). Replacing Oct4 with the neuro-specific factor Brn4 leads to transdifferentiation of fibroblasts into induced neural stem cells (iNSCs). However, Brn4 was recently found to induce transient acquisition of pluripotency b...

journal_title：Cell reports

authors： Velychko S,Kang K,Kim SM,Kwak TH,Kim KP,Park C,Hong K,Chung C,Hyun JK,MacCarthy CM,Wu G,Schöler HR,Han DW

更新日期：2019-04-02 00:00:00

abstract：:The mechanistic target of rapamycin complex 2 (mTORC2) regulates cell survival and cytoskeletal organization by phosphorylating its AGC kinase substrates; however, little is known about the regulation of mTORC2 itself. It was previously reported that Akt phosphorylates the mTORC2 subunit SIN1 at T86, activating mTORC2...

journal_title：Cell reports

authors： Yang G,Murashige DS,Humphrey SJ,James DE

更新日期：2015-08-11 00:00:00

abstract：:Gli proteins are transcriptional effectors of the Hedgehog (Hh) pathway in both normal development and cancer. We describe a program of multisite phosphorylation that regulates the conversion of Gli proteins into transcriptional activators. In the absence of Hh ligands, Gli activity is restrained by the direct phospho...

journal_title：Cell reports

authors： Niewiadomski P,Kong JH,Ahrends R,Ma Y,Humke EW,Khan S,Teruel MN,Novitch BG,Rohatgi R

更新日期：2014-01-16 00:00:00

abstract：:Megakaryocytes (MKs) come from a complex process of hematopoietic progenitor maturation within the bone marrow that gives rise to de novo circulating platelets. Bone marrow microenvironment contains a large number of adipocytes with a still ill-defined role. This study aims to analyze the influence of adipocytes and i...

journal_title：Cell reports

authors： Valet C,Batut A,Vauclard A,Dortignac A,Bellio M,Payrastre B,Valet P,Severin S

更新日期：2020-07-07 00:00:00

abstract：:It is currently assumed that 3D chromosomal organization plays a central role in transcriptional control. However, depletion of cohesin and CTCF affects the steady-state levels of only a minority of transcripts. Here, we use high-resolution Capture Hi-C to interrogate the dynamics of chromosomal contacts of all annota...

journal_title：Cell reports

authors： Thiecke MJ,Wutz G,Muhar M,Tang W,Bevan S,Malysheva V,Stocsits R,Neumann T,Zuber J,Fraser P,Schoenfelder S,Peters JM,Spivakov M

更新日期：2020-07-21 00:00:00

abstract：:People tend to fall asleep when gently rocked or vibrated. Experimental studies have shown that rocking promotes sleep in humans and mice. However, the mechanisms underlying the phenomenon are not well understood. A habituation model proposes that habituation, a form of non-associative learning, mediates sleep inducti...

journal_title：Cell reports

authors： Öztürk-Çolak A,Inami S,Buchler JR,McClanahan PD,Cruz A,Fang-Yen C,Koh K

更新日期：2020-12-01 00:00:00

abstract：:Kappa opioid receptors (KORs) are involved in a variety of aversive behavioral states, including anxiety. To date, a circuit-based mechanism for KOR-driven anxiety has not been described. Here, we show that activation of KORs inhibits glutamate release from basolateral amygdala (BLA) inputs to the bed nucleus of the s...

journal_title：Cell reports

authors： Crowley NA,Bloodgood DW,Hardaway JA,Kendra AM,McCall JG,Al-Hasani R,McCall NM,Yu W,Schools ZL,Krashes MJ,Lowell BB,Whistler JL,Bruchas MR,Kash TL

更新日期：2016-03-29 00:00:00

abstract：:Attempts to generate functional blood cells from human pluripotent stem cells (hPSCs) remain largely unsuccessful, mainly due to the lack of understanding of the regulatory network of human hematopoiesis. In this study, we identified leucine-rich-repeat-containing G-protein-coupled receptor 4 (LGR4) as an essential re...

journal_title：Cell reports

authors： Wang Y,Wang H,Guo J,Gao J,Wang M,Xia M,Wen Y,Su P,Yang M,Liu M,Shi L,Cheng T,Zhou W,Zhou J

更新日期：2020-05-05 00:00:00

abstract：:Chlamydia trachomatis is a human pathogen associated with significant morbidity worldwide. As obligate intracellular parasites, chlamydiae must survive within eukaryotic cells for sufficient time to complete their developmental cycle. To promote host cell survival, chlamydiae express poorly understood anti-apoptotic f...

journal_title：Cell reports

authors： Weber MM,Lam JL,Dooley CA,Noriea NF,Hansen BT,Hoyt FH,Carmody AB,Sturdevant GL,Hackstadt T

更新日期：2017-05-16 00:00:00

abstract：:Embryonic stem cells (ESCs) exhibit high levels of ribosomal RNA (rRNA) transcription and ribosome biogenesis. Here, we reveal an unexpected role for an essential DEAD-box helicase, DDX18, in antagonizing the polycomb repressive complex 2 (PRC2) to prevent deposition of the repressive H3K27me3 mark onto rDNA in plurip...

journal_title：Cell reports

authors： Zhang H,Wu Z,Lu JY,Huang B,Zhou H,Xie W,Wang J,Shen X

更新日期：2020-01-07 00:00:00

abstract：:Immune cells can metabolize glucose, amino acids, and fatty acids (FAs) to generate energy. The roles of different FA species and their impacts on humoral immunity remain poorly understood. Here, we report that proliferating B cells require monounsaturated FAs (MUFAs) to maintain mitochondrial metabolism and mTOR acti...

journal_title：Cell reports

authors： Zhou X,Zhu X,Li C,Li Y,Ye Z,Shapiro VS,Copland JA 3rd,Hitosugi T,Bernlohr DA,Sun J,Zeng H

更新日期：2021-01-05 00:00:00

abstract：:The Fanconi anemia (FA) pathway is critically involved in the maintenance of hematopoietic stem cells and the suppression of carcinogenesis. A key FA protein, FANCD2, is monoubiquitinated and accumulates in chromatin in response to DNA interstrand crosslinks (ICLs), where it coordinates DNA repair through mechanisms t...

journal_title：Cell reports

authors： Unno J,Itaya A,Taoka M,Sato K,Tomida J,Sakai W,Sugasawa K,Ishiai M,Ikura T,Isobe T,Kurumizaka H,Takata M

更新日期：2014-05-22 00:00:00