Partial Inhibition of RNA Polymerase I Promotes Animal Health and Longevity.

Abstract:

:Health and survival in old age can be improved by changes in gene expression. RNA polymerase (Pol) I is the essential, conserved enzyme whose task is to generate the pre-ribosomal RNA (rRNA). We find that reducing the levels of Pol I activity is sufficient to extend lifespan in the fruit fly. This effect can be recapitulated by partial, adult-restricted inhibition, with both enterocytes and stem cells of the adult midgut emerging as important cell types. In stem cells, Pol I appears to act in the same longevity pathway as Pol III, implicating rRNA synthesis in these cells as the key lifespan determinant. Importantly, reduction in Pol I activity delays broad, age-related impairment and pathology, improving the function of diverse organ systems. Hence, our study shows that Pol I activity in the adult drives systemic, age-related decline in animal health and anticipates mortality.

journal_name

Cell Rep

journal_title

Cell reports

authors

Martínez Corrales G,Filer D,Wenz KC,Rogan A,Phillips G,Li M,Feseha Y,Broughton SJ,Alic N

doi

10.1016/j.celrep.2020.01.017

subject

Has Abstract

pub_date

2020-02-11 00:00:00

pages

1661-1669.e4

issue

6

issn

2211-1247

pii

S2211-1247(20)30026-7

journal_volume

30

pub_type

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