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The Adhesion G Protein-Coupled Receptor GPR56/ADGRG1 Is an Inhibitory Receptor on Human NK Cells.

Abstract：

:Natural killer (NK) cells possess potent cytotoxic mechanisms that need to be tightly controlled. Here, we explored the regulation and function of GPR56/ADGRG1, an adhesion G protein-coupled receptor implicated in developmental processes and expressed distinctively in mature NK cells. Expression of GPR56 was triggered by Hobit (a homolog of Blimp-1 in T cells) and declined upon cell activation. Through studying NK cells from polymicrogyria patients with disease-causing mutations in ADGRG1, encoding GPR56, and NK-92 cells ectopically expressing the receptor, we found that GPR56 negatively regulates immediate effector functions, including production of inflammatory cytokines and cytolytic proteins, degranulation, and target cell killing. GPR56 pursues this activity by associating with the tetraspanin CD81. We conclude that GPR56 inhibits natural cytotoxicity of human NK cells.

journal_name

Cell Rep

journal_title

Cell reports

authors

Chang GW,Hsiao CC,Peng YM,Vieira Braga FA,Kragten NA,Remmerswaal EB,van de Garde MD,Straussberg R,König GM,Kostenis E,Knäuper V,Meyaard L,van Lier RA,van Gisbergen KP,Lin HH,Hamann J

doi

10.1016/j.celrep.2016.04.053

subject

Has Abstract

pub_date

2016-05-24 00:00:00

pages

1757-70

issue

8

issn

2211-1247

pii

S2211-1247(16)30480-6

journal_volume

15

pub_type

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