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T lymphocyte potential marks the emergence of definitive hematopoietic progenitors in human pluripotent stem cell differentiation cultures.

Abstract：

:The efficient generation of hematopoietic stem cells from human pluripotent stem cells is dependent on the appropriate specification of the definitive hematopoietic program during differentiation. In this study, we used T lymphocyte potential to track the onset of definitive hematopoiesis from human embryonic and induced pluripotent stem cells differentiated with specific morphogens in serum- and stromal-free cultures. We show that this program develops from a progenitor population with characteristics of hemogenic endothelium, including the expression of CD34, VE-cadherin, GATA2, LMO2, and RUNX1. Along with T cells, these progenitors display the capacity to generate myeloid and erythroid cells. Manipulation of Activin/Nodal signaling during early stages of differentiation revealed that development of the definitive hematopoietic progenitor population is not dependent on this pathway, distinguishing it from primitive hematopoiesis. Collectively, these findings demonstrate that it is possible to generate T lymphoid progenitors from pluripotent stem cells and that this lineage develops from a population whose emergence marks the onset of human definitive hematopoiesis.

journal_name

Cell Rep

journal_title

Cell reports

authors

Kennedy M,Awong G,Sturgeon CM,Ditadi A,LaMotte-Mohs R,Zúñiga-Pflücker JC,Keller G

doi

10.1016/j.celrep.2012.11.003

subject

Has Abstract

pub_date

2012-12-27 00:00:00

pages

1722-35

issue

6

issn

2211-1247

pii

S2211-1247(12)00384-1

journal_volume

2

pub_type

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