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Absence of Specific Chlamydia trachomatis Inclusion Membrane Proteins Triggers Premature Inclusion Membrane Lysis and Host Cell Death.

Abstract：

:Chlamydia trachomatis is a human pathogen associated with significant morbidity worldwide. As obligate intracellular parasites, chlamydiae must survive within eukaryotic cells for sufficient time to complete their developmental cycle. To promote host cell survival, chlamydiae express poorly understood anti-apoptotic factors. Using recently developed genetic tools, we show that three inclusion membrane proteins (Incs) out of eleven examined are required for inclusion membrane stability and avoidance of host cell death pathways. In the absence of specific Incs, premature inclusion lysis results in recognition by autophagolysosomes, activation of intrinsic apoptosis, and premature termination of the chlamydial developmental cycle. Inhibition of autophagy or knockdown of STING prevented host cell death and activation of intrinsic apoptosis. Significantly, these findings emphasize the importance of Incs in the establishment of a replicative compartment that sequesters the pathogen from host surveillance systems.

journal_name

Cell Rep

journal_title

Cell reports

authors

Weber MM,Lam JL,Dooley CA,Noriea NF,Hansen BT,Hoyt FH,Carmody AB,Sturdevant GL,Hackstadt T

doi

10.1016/j.celrep.2017.04.058

subject

Has Abstract

pub_date

2017-05-16 00:00:00

pages

1406-1417

issue

7

issn

2211-1247

pii

S2211-1247(17)30569-7

journal_volume

19

pub_type

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