Enhancing Prefrontal Neuron Activity Enables Associative Learning of Temporally Disparate Events.

abstract：:The fossil record is widely informative about evolution, but fossils are not systematically used to study the evolution of stem-cell-driven renewal. Here, we examined evolution of the continuous growth (hypselodonty) of rodent molar teeth, which is fuelled by the presence of dental stem cells. We studied occurrences o...

journal_title：Cell reports

authors： Tapaltsyan V,Eronen JT,Lawing AM,Sharir A,Janis C,Jernvall J,Klein OD

更新日期：2015-05-05 00:00:00

abstract：:The resolution phase of acute inflammation is essential for tissue homeostasis, yet the underlying mechanisms remain unclear. We demonstrate that resolution of inflammation involves interactions between CD38 and tristetraprolin (TTP). During the onset of acute inflammation, CD38 levels are increased, leading to the pr...

journal_title：Cell reports

authors： Joe Y,Chen Y,Park J,Kim HJ,Rah SY,Ryu J,Cho GJ,Choi HS,Ryter SW,Park JW,Kim UH,Chung HT

更新日期：2020-01-28 00:00:00

abstract：:The Hippo signaling pathway maintains organ size and tissue homeostasis via orchestration of cell proliferation and apoptosis. How this pathway triggers cell apoptosis remains largely unexplored. Here, we identify NR4A1 as a target of the Hippo pathway that mediates the pro-apoptotic and anti-tumor effects of the Hipp...

journal_title：Cell reports

authors： He L,Yuan L,Yu W,Sun Y,Jiang D,Wang X,Feng X,Wang Z,Xu J,Yang R,Zhang W,Feng H,Chen HZ,Zeng YA,Hui L,Wu Q,Zhang Y,Zhang L

更新日期：2020-10-20 00:00:00

abstract：:The guardian of the genome, p53, is often mutated in cancer and may contribute to therapeutic resistance. Given that p53 is intact and functional in normal tissues, we harnessed its potential to inhibit the growth of p53-deficient cancer cells. Specific activation of p53 in normal fibroblasts selectively induced apopt...

journal_title：Cell reports

authors： Burikhanov R,Shrestha-Bhattarai T,Hebbar N,Qiu S,Zhao Y,Zambetti GP,Rangnekar VM

更新日期：2014-01-30 00:00:00

abstract：:Long-lasting forms of synaptic plasticity such as synaptic scaling are critically dependent on transcription. Activity-dependent transcriptional dynamics in neurons, however, remain incompletely characterized because most previous efforts relied on measurement of steady-state mRNAs. Here, we use nascent RNA sequencing...

journal_title：Cell reports

authors： Garay PM,Chen A,Tsukahara T,Rodríguez Díaz JC,Kohen R,Althaus JC,Wallner MA,Giger RJ,Jones KS,Sutton MA,Iwase S

更新日期：2020-08-11 00:00:00

abstract：:The development of sensitive and non-invasive "liquid biopsies" presents new opportunities for longitudinal monitoring of tumor dissemination and clonal evolution. The number of circulating tumor cells (CTCs) is prognostic in multiple myeloma (MM), but there is little information on their genetic features. Here, we ha...

journal_title：Cell reports

authors： Mishima Y,Paiva B,Shi J,Park J,Manier S,Takagi S,Massoud M,Perilla-Glen A,Aljawai Y,Huynh D,Roccaro AM,Sacco A,Capelletti M,Detappe A,Alignani D,Anderson KC,Munshi NC,Prosper F,Lohr JG,Ha G,Freeman SS,Van Allen

更新日期：2017-04-04 00:00:00

abstract：:The role of CD4+ T cells in the ischemic tissues of T2D patients remains unclear. Here, we report that T2D patients' vascular density was negatively correlated with the number of infiltrating CD4+ T cells after ischemic injury. Th1 was the predominant subset, and Th1-derived IFN-γ and TNF-α directly impaired human ang...

journal_title：Cell reports

authors： Leung OM,Li J,Li X,Chan VW,Yang KY,Ku M,Ji L,Sun H,Waldmann H,Tian XY,Huang Y,Lau J,Zhou B,Lui KO

更新日期：2018-08-07 00:00:00

abstract：:Over 80% of pancreatic ductal adenocarcinoma (PDA) patients are diagnosed with non-resectable late-stage disease that lacks effective neoadjuvant therapies. Stereotactic body radiation therapy (SBRT) has shown promise as an emerging neoadjuvant approach for treating PDA, and here, we report that its combination with l...

journal_title：Cell reports

authors： Mills BN,Connolly KA,Ye J,Murphy JD,Uccello TP,Han BJ,Zhao T,Drage MG,Murthy A,Qiu H,Patel A,Figueroa NM,Johnston CJ,Prieto PA,Egilmez NK,Belt BA,Lord EM,Linehan DC,Gerber SA

更新日期：2019-10-08 00:00:00

abstract：:A rare germline duplication upstream of the bone morphogenetic protein antagonist GREM1 causes a Mendelian-dominant predisposition to colorectal cancer (CRC). The underlying disease mechanism is strong, ectopic GREM1 overexpression in the intestinal epithelium. Here, we confirm that a common GREM1 polymorphism, rs1696...

journal_title：Cell reports

authors： Lewis A,Freeman-Mills L,de la Calle-Mustienes E,Giráldez-Pérez RM,Davis H,Jaeger E,Becker M,Hubner NC,Nguyen LN,Zeron-Medina J,Bond G,Stunnenberg HG,Carvajal JJ,Gomez-Skarmeta JL,Leedham S,Tomlinson I

更新日期：2014-08-21 00:00:00

abstract：:Our knowledge of transcriptional heterogeneities in epithelial stem and progenitor cell compartments is limited. Epidermal basal cells sustain cutaneous tissue maintenance and drive wound healing. Previous studies have probed basal cell heterogeneity in stem and progenitor potential, but a comprehensive dissection of ...

journal_title：Cell reports

authors： Haensel D,Jin S,Sun P,Cinco R,Dragan M,Nguyen Q,Cang Z,Gong Y,Vu R,MacLean AL,Kessenbrock K,Gratton E,Nie Q,Dai X

更新日期：2020-03-17 00:00:00

abstract：:Horizontal transmission of the microbiota between different individuals is widely used to normalize the microbiota in laboratory mice. However, little is known about the dynamics of microbial communities and the level of microbiota transmission after cohousing. We extensively analyzed the fecal microbiota in Jackson a...

journal_title：Cell reports

authors： Caruso R,Ono M,Bunker ME,Núñez G,Inohara N

更新日期：2019-06-11 00:00:00

abstract：:Infections can result in a temporarily restricted unresponsiveness of the innate immune response, thereby limiting pathogen control. Mechanisms of such unresponsiveness are well studied in lipopolysaccharide tolerance; however, whether mechanisms of tolerance limit innate immunity during virus infection remains unknow...

journal_title：Cell reports

authors： Adomati T,Cham LB,Hamdan TA,Bhat H,Duhan V,Li F,Ali M,Lang E,Huang A,Naser E,Khairnar V,Friedrich SK,Lang J,Friebus-Kardash J,Bergerhausen M,Schiller M,Machlah YM,Lang F,Häussinger D,Ferencik S,Hardt C,Lang PA,

更新日期：2020-03-17 00:00:00

abstract：:Neurogenesis continues in the ventricular-subventricular zone (V-SVZ) of the adult forebrain from quiescent neural stem cells (NSCs). V-SVZ NSCs are a reservoir for new olfactory bulb (OB) neurons that migrate through the rostral migratory stream (RMS). To generate neurons, V-SVZ NSCs need to activate and enter the ce...

journal_title：Cell reports

authors： Engler A,Rolando C,Giachino C,Saotome I,Erni A,Brien C,Zhang R,Zimber-Strobl U,Radtke F,Artavanis-Tsakonas S,Louvi A,Taylor V

更新日期：2018-01-23 00:00:00

abstract：:Although it is well established that tumor-associated macrophages take part in each step of cancer progression, less is known about the distinct role of the so-called metastasis-associated macrophages (MAMs) at the metastatic site. Previous studies reported that Caveolin-1 (Cav1) has both tumor-promoting and tumor-sup...

journal_title：Cell reports

authors： Celus W,Di Conza G,Oliveira AI,Ehling M,Costa BM,Wenes M,Mazzone M

更新日期：2017-12-05 00:00:00

abstract：:Chronic exposure to nicotine upregulates nicotinic acetylcholine receptors (nAChRs), and such upregulation is critical for the development of nicotine dependence in humans and animal models. However, how nicotine upregulates nAChRs is not well understood. Here, we identify a key role for microRNA in regulating nicotin...

journal_title：Cell reports

authors： Rauthan M,Gong J,Liu J,Li Z,Wescott SA,Liu J,Xu XZS

更新日期：2017-11-07 00:00:00

abstract：:Protein-coding genes undergo a wide array of regulatory interactions with factors that engage non-coding regions. Open reading frames (ORFs), in contrast, are thought to be constrained by coding function, precluding a major role in gene regulation. Here, we explore Piwi-interacting (pi)RNA-mediated transgene silencing...

journal_title：Cell reports

authors： Seth M,Shirayama M,Tang W,Shen EZ,Tu S,Lee HC,Weng Z,Mello CC

更新日期：2018-02-27 00:00:00

abstract：:The p110β isoform of PI3K is preferentially activated in many tumors deficient in the phosphatase and tensin homolog (PTEN). However, the mechanism(s) linking PTEN loss to p110β activation remain(s) mysterious. Here, we identify CRKL as a member of the class of PI3Kβ-interacting proteins. Silencing CRKL expression in ...

journal_title：Cell reports

authors： Zhang J,Gao X,Schmit F,Adelmant G,Eck MJ,Marto JA,Zhao JJ,Roberts TM

更新日期：2017-07-18 00:00:00

abstract：:In contrast to our extensive knowledge on covalent small ubiquitin-like modifier (SUMO) target proteins, we are limited in our understanding of non-covalent SUMO-binding proteins. We identify interactors of different SUMO isoforms-monomeric SUMO1, monomeric SUMO2, or linear trimeric SUMO2 chains-using a mass spectrome...

journal_title：Cell reports

authors： González-Prieto R,Eifler-Olivi K,Claessens LA,Willemstein E,Xiao Z,Talavera Ormeno CMP,Ovaa H,Ulrich HD,Vertegaal ACO

更新日期：2021-01-26 00:00:00

abstract：:Wnt signaling is intrinsic to mouse embryonic stem cell self-renewal. Therefore, it is surprising that reprogramming of somatic cells to induced pluripotent stem cells (iPSCs) is not strongly enhanced by Wnt signaling. Here, we demonstrate that active Wnt signaling inhibits the early stage of reprogramming to iPSCs, w...

journal_title：Cell reports

authors： Ho R,Papp B,Hoffman JA,Merrill BJ,Plath K

更新日期：2013-06-27 00:00:00

abstract：:Oligodendrogenesis occurs during early postnatal development, coincident with neurogenesis and synaptogenesis, raising the possibility that microglia-dependent pruning mechanisms that modulate neurons regulate myelin sheath formation. Here we show a population of ameboid microglia migrating from the ventricular zone i...

journal_title：Cell reports

authors： Nemes-Baran AD,White DR,DeSilva TM

更新日期：2020-08-18 00:00:00

abstract：:Quiescence is a fundamental property of adult stem cells. Recent evidence indicates that quiescence is not a default state but requires active signaling that prevents accidental or untimely activation of stem cells. The calcitonin receptor (CalcR) is critical for sustaining quiescence in muscle satellite (stem) cells ...

journal_title：Cell reports

authors： Zhang L,Noguchi YT,Nakayama H,Kaji T,Tsujikawa K,Ikemoto-Uezumi M,Uezumi A,Okada Y,Doi T,Watanabe S,Braun T,Fujio Y,Fukada SI

更新日期：2019-11-19 00:00:00

abstract：:How ubiquitous transcription factors (TFs) coordinate temporal inputs from broadly expressed epigenetic factors to control cell fate remains poorly understood. Here, we uncover a molecular relationship between p53, an abundant embryonic TF, and WDR5, an essential member of the MLL chromatin modifying complex, that reg...

journal_title：Cell reports

authors： Li Q,Mao F,Zhou B,Huang Y,Zou Z,denDekker AD,Xu J,Hou S,Liu J,Dou Y,Rao RC

更新日期：2020-01-14 00:00:00

abstract：:Medium spiny neurons (MSNs) of mice show opposing activities upon the initiation of a food-seeking lever press task. Ventromedial striatal (VMS)-MSNs are inhibited but ventrolateral striatal (VLS)-MSNs are activated; these activities mediate action selection and action initiation, respectively. To understand what inpu...

journal_title：Cell reports

authors： Yoshida K,Tsutsui-Kimura I,Kono A,Yamanaka A,Kobayashi K,Watanabe M,Mimura M,Tanaka KF

更新日期：2020-06-30 00:00:00

abstract：:Memories are believed to be stored in distributed neuronal assemblies through activity-induced changes in synaptic and intrinsic properties. However, the specific mechanisms by which different memories become associated or linked remain a mystery. Here, we develop a simplified, biophysically inspired network model tha...

journal_title：Cell reports

authors： Kastellakis G,Silva AJ,Poirazi P

更新日期：2016-11-01 00:00:00

abstract：:53BP1 plays a central role in dictating DNA repair choice between non-homologous end joining (NHEJ) and homologous recombination (HR), which is important for the sensitivity to poly(ADP-ribose) polymerase inhibitors (PARPis) of BRCA1-deficient cancers. In this study, we show that FOXK1 associates with 53BP1 and regula...

journal_title：Cell reports

authors： Tang M,Feng X,Pei G,Srivastava M,Wang C,Chen Z,Li S,Zhang H,Zhao Z,Li X,Chen J

更新日期：2020-08-11 00:00:00

abstract：:The Argonaute subfamily of proteins (AGO) loads microRNAs (miRNAs) to form the effector complex that mediates target gene silencing. Empty AGO, but not miRNA-loaded AGO, is selectively degraded across species. We have reported that the degradation of empty AGO is part of a quality control pathway that eliminates dysfu...

journal_title：Cell reports

authors： Kobayashi H,Shoji K,Kiyokawa K,Negishi L,Tomari Y

更新日期：2019-07-30 00:00:00

abstract：:Antimetabolites that affect nucleotide metabolism are frontline chemotherapy agents in several cancers and often successfully target one carbon metabolism. However, the precise mechanisms and resulting determinants of their therapeutic value are unknown. We show that 5-fluorouracil (5-FU), a commonly used antimetaboli...

journal_title：Cell reports

authors： Ser Z,Gao X,Johnson C,Mehrmohamadi M,Liu X,Li S,Locasale JW

更新日期：2016-06-14 00:00:00

abstract：:DNA polymerase ζ (Polζ) is specialized for the extension step of translesion DNA synthesis (TLS). Despite its central role in maintaining genome integrity, little is known about its overall architecture. Initially identified as a heterodimer of the catalytic subunit Rev3 and the accessory subunit Rev7, yeast Polζ has ...

journal_title：Cell reports

authors： Gómez-Llorente Y,Malik R,Jain R,Choudhury JR,Johnson RE,Prakash L,Prakash S,Ubarretxena-Belandia I,Aggarwal AK

更新日期：2013-10-17 00:00:00

abstract：:Characterization of the cardiac cellulome, the network of cells that form the heart, is essential for understanding cardiac development and normal organ function and for formulating precise therapeutic strategies to combat heart disease. Recent studies have reshaped our understanding of cardiac cellular composition an...

journal_title：Cell reports

authors： Skelly DA,Squiers GT,McLellan MA,Bolisetty MT,Robson P,Rosenthal NA,Pinto AR

更新日期：2018-01-16 00:00:00

abstract：:The histone methyl transferase enhancer of zeste homolog 2 (EZH2) is a master transcriptional regulator involved in histone H3 lysine 27 trimethylation. We aimed to elucidate the precise post-translational regulations of EZH2 and their role in cancer pathogenesis. Here, we show that SET and MYND domain containing 2 (S...

journal_title：Cell reports

authors： Zeng Y,Qiu R,Yang Y,Gao T,Zheng Y,Huang W,Gao J,Zhang K,Liu R,Wang S,Hou Y,Yu W,Leng S,Feng D,Liu W,Zhang X,Wang Y

更新日期：2019-11-05 00:00:00