Defining Epidermal Basal Cell States during Skin Homeostasis and Wound Healing Using Single-Cell Transcriptomics.

abstract：:The Hippo signaling pathway maintains organ size and tissue homeostasis via orchestration of cell proliferation and apoptosis. How this pathway triggers cell apoptosis remains largely unexplored. Here, we identify NR4A1 as a target of the Hippo pathway that mediates the pro-apoptotic and anti-tumor effects of the Hipp...

journal_title：Cell reports

authors： He L,Yuan L,Yu W,Sun Y,Jiang D,Wang X,Feng X,Wang Z,Xu J,Yang R,Zhang W,Feng H,Chen HZ,Zeng YA,Hui L,Wu Q,Zhang Y,Zhang L

更新日期：2020-10-20 00:00:00

abstract：:The segregation of chromosomes is a critical step during cell division. This process is driven by the elongation of spindle microtubules and is tightly regulated by checkpoint mechanisms. It is unknown whether microtubules affect checkpoint responses as passive contributors or active regulators of the process. We show...

journal_title：Cell reports

authors： Laflamme G,Sim S,Leary A,Pascariu M,Vogel J,D'Amours D

更新日期：2019-03-12 00:00:00

abstract：:Activation of phosphoinositide 3-kinase (PI3K) signaling plays a central role in regulating proliferation and survival of B cells. Here, we tested the hypothesis that B cell receptor (BCR)-mediated activation of PI3K induces the terminal differentiation factor Blimp-1 that interferes with proliferation and survival, t...

journal_title：Cell reports

authors： Setz CS,Hug E,Khadour A,Abdelrasoul H,Bilal M,Hobeika E,Jumaa H

更新日期：2018-07-10 00:00:00

abstract：:ADP-ribosylation (ADPr) is a reversible posttranslational modification involved in a range of cellular processes. Here, we report system-wide identification of serine ADPr in human cells upon oxidative stress. High-resolution mass spectrometry and unrestricted data processing confirm that serine residues are the major...

journal_title：Cell reports

authors： Larsen SC,Hendriks IA,Lyon D,Jensen LJ,Nielsen ML

更新日期：2018-08-28 00:00:00

abstract：:Current treatment regimens for pancreatic ductal adenocarcinoma (PDAC) yield poor 5-year survival, emphasizing the critical need to identify druggable targets essential for PDAC maintenance. We developed an unbiased and in vivo target discovery approach to identify molecular vulnerabilities in low-passage and patient-...

journal_title：Cell reports

authors： Carugo A,Genovese G,Seth S,Nezi L,Rose JL,Bossi D,Cicalese A,Shah PK,Viale A,Pettazzoni PF,Akdemir KC,Bristow CA,Robinson FS,Tepper J,Sanchez N,Gupta S,Estecio MR,Giuliani V,Dellino GI,Riva L,Yao W,Di Francesco

更新日期：2016-06-28 00:00:00

abstract：:It is known that plant cells can contain multiple distinct vacuoles; however, the abundance of multivacuolar cells and the mechanisms underlying vacuolar differentiation and communication among different types of vacuoles remain unknown. PH1 and PH5 are tonoplast P-ATPases that form a heteromeric pump that hyper-acidi...

journal_title：Cell reports

authors： Faraco M,Li Y,Li S,Spelt C,Di Sansebastiano GP,Reale L,Ferranti F,Verweij W,Koes R,Quattrocchio FM

更新日期：2017-06-20 00:00:00

abstract：:Protein isoforms generated by alternative splicing contribute to proteome diversity. Because of the lack of effective techniques, the isoform-specific function, expression, localization, and signaling of endogenous proteins are unknown for most genes. Here, we report a genetic method, isoTarget, for multi-purpose stud...

journal_title：Cell reports

authors： Liu H,Pizzano S,Li R,Zhao W,Veling MW,Hu Y,Yang L,Ye B

更新日期：2020-11-10 00:00:00

abstract：:Electrons feed into the mitochondrial electron transport chain (mETC) from NAD- or FAD-dependent enzymes. A shift from glucose to fatty acids increases electron flux through FAD, which can saturate the oxidation capacity of the dedicated coenzyme Q (CoQ) pool and result in the generation of reactive oxygen species. To...

journal_title：Cell reports

authors： Guarás A,Perales-Clemente E,Calvo E,Acín-Pérez R,Loureiro-Lopez M,Pujol C,Martínez-Carrascoso I,Nuñez E,García-Marqués F,Rodríguez-Hernández MA,Cortés A,Diaz F,Pérez-Martos A,Moraes CT,Fernández-Silva P,Trifunovic A,Navas

更新日期：2016-04-05 00:00:00

abstract：:The accumulation of damage caused by oxidative stress has been linked to aging and to the etiology of numerous age-related diseases. The longevity gene, sirtuin 6 (SIRT6), promotes genome stability by facilitating DNA repair, especially under oxidative stress conditions. Here we uncover the mechanism by which SIRT6 is...

journal_title：Cell reports

authors： Van Meter M,Simon M,Tombline G,May A,Morello TD,Hubbard BP,Bredbenner K,Park R,Sinclair DA,Bohr VA,Gorbunova V,Seluanov A

更新日期：2016-09-06 00:00:00

abstract：:Neutrophil polarity relies on local, mutual inhibition to segregate incompatible signaling circuits to the leading and trailing edges. Mutual inhibition alone should lead to cells having strong fronts and weak backs or vice versa. However, analysis of cell-to-cell variation in human neutrophils revealed that back pola...

journal_title：Cell reports

authors： Wang Y,Ku CJ,Zhang ER,Artyukhin AB,Weiner OD,Wu LF,Altschuler SJ

更新日期：2013-05-30 00:00:00

abstract：:The thalamus plays a central role in sleep rhythms in the mammalian brain and, yet, surprisingly little is known about its function and interaction with local cortical oscillations during NREM sleep (NREM). We investigated the neuronal correlates of cortical barrel activity in the two corresponding thalamic nuclei, th...

journal_title：Cell reports

authors： Urbain N,Fourcaud-Trocmé N,Laheux S,Salin PA,Gentet LJ

更新日期：2019-02-05 00:00:00

abstract：:Aging strongly influences human morbidity and mortality. Thus, aging-preventive compounds could greatly improve our health and lifespan. Here we screened for such compounds, known as geroprotectors, employing the power of transcriptomics to predict biological age. Using age-stratified human tissue transcriptomes and m...

journal_title：Cell reports

authors： Janssens GE,Lin XX,Millan-Ariño L,Kavšek A,Sen I,Seinstra RI,Stroustrup N,Nollen EAA,Riedel CG

更新日期：2019-04-09 00:00:00

abstract：:The use of retinal organoids requires efficient differentiation from induced pluripotent stem cells (iPSCs). In this issue of Cell Reports, Wang et al. (2018) examine how the chromatin landscape after iPSC programming predicts their ability to differentiate into retinal tissue. ...

journal_title：Cell reports

authors： Roberts JM,Vetter ML

更新日期：2018-03-06 00:00:00

abstract：:Insulin-stimulated hepatic glycogen synthesis is central to glucose homeostasis. Here, we show that PPP1R3G, a regulatory subunit of protein phosphatase 1 (PP1), is directly phosphorylated by AKT. PPP1R3G phosphorylation fluctuates with fasting-refeeding cycle and is required for insulin-stimulated dephosphorylation, ...

journal_title：Cell reports

authors： Li Q,Zhao Q,Zhang J,Zhou L,Zhang W,Chua B,Chen Y,Xu L,Li P

更新日期：2019-09-24 00:00:00

abstract：:A systematic cataloging of genes affected by genomic rearrangement, using multiple patient cohorts and cancer types, can provide insight into cancer-relevant alterations outside of exomes. By integrative analysis of whole-genome sequencing (predominantly low pass) and gene expression data from 1,448 cancers involving ...

journal_title：Cell reports

authors： Zhang Y,Yang L,Kucherlapati M,Chen F,Hadjipanayis A,Pantazi A,Bristow CA,Lee EA,Mahadeshwar HS,Tang J,Zhang J,Seth S,Lee S,Ren X,Song X,Sun H,Seidman J,Luquette LJ,Xi R,Chin L,Protopopov A,Li W,Park PJ,Kuche

更新日期：2018-07-10 00:00:00

abstract：:Oct4 is an essential regulator of pluripotency in vivo and in vitro in embryonic stem cells, as well as a key mediator of the reprogramming of somatic cells into induced pluripotent stem cells. It is not known whether activation and/or repression of specific genes by Oct4 is relevant to these functions. Here, we show ...

journal_title：Cell reports

authors： Hammachi F,Morrison GM,Sharov AA,Livigni A,Narayan S,Papapetrou EP,O'Malley J,Kaji K,Ko MS,Ptashne M,Brickman JM

更新日期：2012-02-23 00:00:00

abstract：:Although bacterial cell morphology is tightly controlled, the principles of size regulation remain elusive. In Escherichia coli, perturbation of cell-wall synthesis often results in similar morphologies, making it difficult to deconvolve the complex genotype-phenotype relationships underlying morphogenesis. Here we mo...

journal_title：Cell reports

authors： Tropini C,Lee TK,Hsin J,Desmarais SM,Ursell T,Monds RD,Huang KC

更新日期：2014-11-20 00:00:00

abstract：:Cancer stem cells (CSCs) are associated with the refractory nature of cancer, and elucidating the targetable pathways for CSCs is crucial for devising innovative antitumor therapies. We find that the proliferation of CSC-enriched colon spheroids from clinical specimen is dependent on mTORC1 kinase, which is activated ...

journal_title：Cell reports

authors： Ohata H,Shiokawa D,Obata Y,Sato A,Sakai H,Fukami M,Hara W,Taniguchi H,Ono M,Nakagama H,Okamoto K

更新日期：2019-07-30 00:00:00

abstract：:Chlamydia trachomatis is a human pathogen associated with significant morbidity worldwide. As obligate intracellular parasites, chlamydiae must survive within eukaryotic cells for sufficient time to complete their developmental cycle. To promote host cell survival, chlamydiae express poorly understood anti-apoptotic f...

journal_title：Cell reports

authors： Weber MM,Lam JL,Dooley CA,Noriea NF,Hansen BT,Hoyt FH,Carmody AB,Sturdevant GL,Hackstadt T

更新日期：2017-05-16 00:00:00

abstract：:The flat bones of the skull are densely innervated during development, but little is known regarding their role during repair. We describe a neurotrophic mechanism that directs sensory nerve transit in the mouse calvaria. Patent cranial suture mesenchyme represents an NGF (nerve growth factor)-rich domain, in which se...

journal_title：Cell reports

authors： Meyers CA,Lee S,Sono T,Xu J,Negri S,Tian Y,Wang Y,Li Z,Miller S,Chang L,Gao Y,Minichiello L,Clemens TL,James AW

更新日期：2020-05-26 00:00:00

abstract：:Neurons face unique transport challenges. They need to deliver cargo over long axonal distances and to many presynaptic nerve terminals. Rab GTPases are master regulators of vesicular traffic, but essential presynaptic Rabs have not been identified. Here, we find that Rab6, a Golgi-derived GTPase for constitutive secr...

journal_title：Cell reports

authors： Nyitrai H,Wang SSH,Kaeser PS

更新日期：2020-06-09 00:00:00

abstract：:The cerebral cortex is organized in vertical columns that contain neurons with similar functions. The cellular micro-architecture of such columns is an essential determinant of brain dynamics and cortical information processing. However, a detailed understanding of columns is incomplete, even in the best studied corti...

journal_title：Cell reports

authors： Tischbirek CH,Noda T,Tohmi M,Birkner A,Nelken I,Konnerth A

更新日期：2019-04-30 00:00:00

abstract：:Early lineage-specific master regulators are essential for the specification of cell types. However, once cells are committed to a specific fate, it is critical to restrict the activity of such factors to enable differentiation. To date, it remains unclear how these factors are silenced. Using the Drosophila mesoderm ...

journal_title：Cell reports

authors： Domsch K,Schröder J,Janeschik M,Schaub C,Lohmann I

更新日期：2021-01-05 00:00:00

abstract：:The innate immune system senses cytosolic dsDNA and bacterial cyclic dinucleotides and initiates signaling via the adaptor STING to induce type 1 interferon (IFN) response. We demonstrate here that BTK-deficient cells have impaired IFN-β production and TBK1/IRF3 activation when stimulated with agonists or infected wit...

journal_title：Cell reports

authors： Lee KG,Kim SS,Kui L,Voon DC,Mauduit M,Bist P,Bi X,Pereira NA,Liu C,Sukumaran B,Rénia L,Ito Y,Lam KP

更新日期：2015-02-24 00:00:00

abstract：:Simultaneous expression of Oct4, Klf4, Sox2, and cMyc induces pluripotency in somatic cells (iPSCs). Replacing Oct4 with the neuro-specific factor Brn4 leads to transdifferentiation of fibroblasts into induced neural stem cells (iNSCs). However, Brn4 was recently found to induce transient acquisition of pluripotency b...

journal_title：Cell reports

authors： Velychko S,Kang K,Kim SM,Kwak TH,Kim KP,Park C,Hong K,Chung C,Hyun JK,MacCarthy CM,Wu G,Schöler HR,Han DW

更新日期：2019-04-02 00:00:00

abstract：:To survive adverse and ever-changing environmental conditions, an organism must be able to adapt. It has long been established that the cellular reaction to stress includes the upregulation of genes coding for specific stress-responsive factors. In the present study, we demonstrate that during the early steps of the h...

journal_title：Cell reports

authors： Merret R,Descombin J,Juan YT,Favory JJ,Carpentier MC,Chaparro C,Charng YY,Deragon JM,Bousquet-Antonelli C

更新日期：2013-12-12 00:00:00

abstract：:Training-dependent increases in c-fos have been used to identify engram cells encoding long-term memories (LTMs). However, the interaction between transcription factors required for LTM, including CREB and c-Fos, and activating kinases such as phosphorylated ERK (pERK) in the establishment of memory engrams has been u...

journal_title：Cell reports

authors： Miyashita T,Kikuchi E,Horiuchi J,Saitoe M

更新日期：2018-12-04 00:00:00

abstract：:Loss of metabolic homeostasis is a hallmark of aging and is commonly characterized by the deregulation of adaptive signaling interactions that coordinate energy metabolism with dietary changes. The mechanisms driving age-related changes in these adaptive responses remain unclear. Here, we characterize the deregulation...

journal_title：Cell reports

authors： Karpac J,Biteau B,Jasper H

更新日期：2013-09-26 00:00:00

abstract：:Brain plasticity is often restricted to critical periods in early life. Here, we show that a key regulator of this process in the visual cortex, Otx2 homeoprotein, is synthesized and secreted globally from the choroid plexus. Consequently, Otx2 is maintained in selected GABA cells unexpectedly throughout the mature fo...

journal_title：Cell reports

authors： Spatazza J,Lee HH,Di Nardo AA,Tibaldi L,Joliot A,Hensch TK,Prochiantz A

更新日期：2013-06-27 00:00:00

abstract：:Even though hyperthermia is a promising treatment for cancer, the relationship between specific temperatures and clinical benefits and predictors of sensitivity of cancer to hyperthermia is poorly understood. Ovarian and uterine tumors have diverse hyperthermia sensitivities. Integrative analyses of the specific gene ...

journal_title：Cell reports

authors： Hatakeyama H,Wu SY,Lyons YA,Pradeep S,Wang W,Huang Q,Court KA,Liu T,Nie S,Rodriguez-Aguayo C,Shen F,Huang Y,Hisamatsu T,Mitamura T,Jennings N,Shim J,Dorniak PL,Mangala LS,Petrillo M,Petyuk VA,Schepmoes AA,Shukla

更新日期：2016-11-01 00:00:00