Abstract：
:The p110β isoform of PI3K is preferentially activated in many tumors deficient in the phosphatase and tensin homolog (PTEN). However, the mechanism(s) linking PTEN loss to p110β activation remain(s) mysterious. Here, we identify CRKL as a member of the class of PI3Kβ-interacting proteins. Silencing CRKL expression in PTEN-null human cancer cells leads to a decrease in p110β-dependent PI3K signaling and cell proliferation. In contrast, CRKL depletion does not impair p110α-mediated signaling. Further study showed that CRKL binds to tyrosine-phosphorylated p130Cas in PTEN-null cancer cells. Since Src family kinases are known both to be regulated by PTEN and to phosphorylate and activate p130Cas, we tested and found that Src inhibition cooperated with p110β inhibition to suppress the growth of PTEN-null cells. These data suggest both a potential mechanism linking PTEN loss to p110β activation and the possible benefit of dual inhibition of Src and PI3K for PTEN-null tumors.
journal_name
Cell Repjournal_title
Cell reportsauthors
Zhang J,Gao X,Schmit F,Adelmant G,Eck MJ,Marto JA,Zhao JJ,Roberts TMdoi
10.1016/j.celrep.2017.06.054subject
Has Abstractpub_date
2017-07-18 00:00:00pages
549-557issue
3issn
2211-1247pii
S2211-1247(17)30885-9journal_volume
20pub_type
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