Abstract：
:Naturally acquired immunity to malaria develops only after years of repeated exposure to Plasmodium parasites. Despite the key role antibodies play in protection, the cellular processes underlying the slow acquisition of immunity remain unknown. Using mouse models, we show that severe malaria infection inhibits the establishment of germinal centers (GCs) in the spleen. We demonstrate that infection induces high frequencies of T follicular helper (Tfh) cell precursors but results in impaired Tfh cell differentiation. Despite high expression of Bcl-6 and IL-21, precursor Tfh cells induced during infection displayed low levels of PD-1 and CXCR5 and co-expressed Th1-associated molecules such as T-bet and CXCR3. Blockade of the inflammatory cytokines TNF and IFN-γ or T-bet deletion restored Tfh cell differentiation and GC responses to infection. Thus, this study demonstrates that the same pro-inflammatory mediators that drive severe malaria pathology have detrimental effects on the induction of protective B cell responses.
journal_name
Cell Repjournal_title
Cell reportsauthors
Ryg-Cornejo V,Ioannidis LJ,Ly A,Chiu CY,Tellier J,Hill DL,Preston SP,Pellegrini M,Yu D,Nutt SL,Kallies A,Hansen DSdoi
10.1016/j.celrep.2015.12.006subject
Has Abstractpub_date
2016-01-05 00:00:00pages
68-81issue
1issn
2211-1247pii
S2211-1247(15)01418-7journal_volume
14pub_type
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