Innate Lymphoid Cells in the Induction of Obesity.

abstract：:In fission yeast, the transcription factor Pap1 undergoes H2O2-dependent oxidation that promotes its nuclear accumulation and the activation of an antioxidant gene program. However, the mechanisms that regulate the sensitivity and selectivity of Pap1 activation by peroxides are not fully understood. Here, we demonstra...

journal_title：Cell reports

authors： Calvo IA,Boronat S,Domènech A,García-Santamarina S,Ayté J,Hidalgo E

更新日期：2013-12-12 00:00:00

abstract：:As the key effector in the Hippo pathway, YAP was identified as an oncoprotein whose expression is elevated in various human cancers. However, the development of potentially therapeutic compounds targeting YAP has been slow and limited. Here, we find that tankyrase inhibitors suppress YAP activity. This effect is medi...

journal_title：Cell reports

authors： Wang W,Li N,Li X,Tran MK,Han X,Chen J

更新日期：2015-10-20 00:00:00

abstract：:Embryonic stem cells (ESCs) hold promise for the treatment of many medical conditions; however, their utility is limited by immune rejection. The objective of our study is to establish tolerance or promote engraftment of transplanted ESCs as well as mature cell populations derived from ESCs. Luciferase (luc(+))-expres...

journal_title：Cell reports

authors： Pan Y,Leveson-Gower DB,de Almeida PE,Pierini A,Baker J,Florek M,Nishikii H,Kim BS,Ke R,Wu JC,Negrin RS

更新日期：2015-03-24 00:00:00

abstract：:Interleukin-1 receptor antagonist (IL-1Ra) is elevated in the circulation during obesity and type 2 diabetes (T2D) but is decreased in islets from patients with T2D. The protective role of local IL-1Ra was investigated in pancreatic islet β cell (βIL-1Ra)-specific versus myeloid-cell (myeloIL-1Ra)-specific IL-1Ra knoc...

journal_title：Cell reports

authors： Böni-Schnetzler M,Häuselmann SP,Dalmas E,Meier DT,Thienel C,Traub S,Schulze F,Steiger L,Dror E,Martin P,Herrera PL,Gabay C,Donath MY

更新日期：2018-02-13 00:00:00

abstract：:Arrival of encephalitogenic T cells at inflammatory foci represents a critical step in development of experimental autoimmune encephalomyelitis (EAE), the animal model for multiple sclerosis. EBI2 and its ligand, 7α,25-OHC, direct immune cell localization in secondary lymphoid organs. CH25H and CYP7B1 hydroxylate chol...

journal_title：Cell reports

authors： Wanke F,Moos S,Croxford AL,Heinen AP,Gräf S,Kalt B,Tischner D,Zhang J,Christen I,Bruttger J,Yogev N,Tang Y,Zayoud M,Israel N,Karram K,Reißig S,Lacher SM,Reichhold C,Mufazalov IA,Ben-Nun A,Kuhlmann T,Wettschureck

更新日期：2017-01-31 00:00:00

abstract：:Nonalcoholic fatty liver disease is the most common chronic liver disorder in developed countries. Its pathogenesis is poorly understood, and therapeutic options are limited. Here, we show that SIRT7, an NAD(+)-dependent H3K18Ac deacetylase, functions at chromatin to suppress ER stress and prevent the development of f...

journal_title：Cell reports

authors： Shin J,He M,Liu Y,Paredes S,Villanova L,Brown K,Qiu X,Nabavi N,Mohrin M,Wojnoonski K,Li P,Cheng HL,Murphy AJ,Valenzuela DM,Luo H,Kapahi P,Krauss R,Mostoslavsky R,Yancopoulos GD,Alt FW,Chua KF,Chen D

更新日期：2013-11-14 00:00:00

abstract：:In neurons, transmembrane proteins are targeted to dendrites in vesicles that traffic solely within the somatodendritic compartment. How these vesicles are retained within the somatodendritic domain is unknown. Here, we use a novel pulse-chase system, which allows synchronous release of exogenous transmembrane protein...

journal_title：Cell reports

authors： Al-Bassam S,Xu M,Wandless TJ,Arnold DB

更新日期：2012-07-26 00:00:00

abstract：:Mutations in BLM helicase predispose Bloom syndrome (BS) patients to a wide spectrum of cancers. We demonstrate that MIB1-ubiquitylated BLM in G1 phase functions as an adaptor protein by enhancing the binding of transcription factor c-Jun and its E3 ligase, Fbw7α. BLM enhances the K48/K63-linked ubiquitylation on c-Ju...

journal_title：Cell reports

authors： Priyadarshini R,Hussain M,Attri P,Kaur E,Tripathi V,Priya S,Dhapola P,Saha D,Madhavan V,Chowdhury S,Sengupta S

更新日期：2018-07-24 00:00:00

abstract：:To understand how the Bcl6 transcriptional repressor functions in the immune system, we disrupted its RD2 repression domain in mice. Bcl6RD2(MUT) mice exhibit a complete loss of germinal center (GC) formation but retain normal extrafollicular responses. Bcl6RD2(MUT) antigen-engaged B cells migrate to the interfollicul...

journal_title：Cell reports

authors： Huang C,Gonzalez DG,Cote CM,Jiang Y,Hatzi K,Teater M,Dai K,Hla T,Haberman AM,Melnick A

更新日期：2014-09-11 00:00:00

abstract：:The Fanconi anemia (FA) pathway repairs DNA interstrand crosslinks (ICLs). Many FA proteins are recruited to ICLs in a timely fashion so that coordinated repair can occur. However, the mechanism of this process is poorly understood. Here, we report the purification of a FANCD2-containing protein complex with multiple ...

journal_title：Cell reports

authors： Socha A,Yang D,Bulsiewicz A,Yaprianto K,Kupculak M,Liang CC,Hadjicharalambous A,Wu R,Gygi SP,Cohn MA

更新日期：2020-07-07 00:00:00

abstract：:Brain networks contain a large diversity of functionally distinct neuronal elements, each with unique properties, enabling computational capacities and supporting brain functions. Understanding their functional implications for behavior requires the precise identification of the cell types of a network and in vivo mon...

journal_title：Cell reports

authors： Muñoz W,Tremblay R,Rudy B

更新日期：2014-12-24 00:00:00

abstract：:Self-renewal is a key characteristic of leukemia stem cells (LSCs) responsible for the development and maintenance of leukemia. In this study, we identify CD93 as an important regulator of self-renewal and proliferation of murine and human LSCs, but not hematopoietic stem cells (HSCs). The intracellular domain of CD93...

journal_title：Cell reports

authors： Riether C,Radpour R,Kallen NM,Bürgin DT,Bachmann C,Schürch CM,Lüthi U,Arambasic M,Hoppe S,Albers CE,Baerlocher GM,Ochsenbein AF

更新日期：2021-01-26 00:00:00

abstract：:Small cytoplasmic mRNP granules are implicated in mRNA transport, translational control, and decay. Using super-resolution microscopy and fluorescence correlation spectroscopy, we analyzed the molecular composition and dynamics of single cytoplasmic YBX1_IMP1 mRNP granules in live cells. Granules appeared elongated an...

journal_title：Cell reports

authors： Mateu-Regué À,Christiansen J,Bagger FO,Winther O,Hellriegel C,Nielsen FC

更新日期：2019-10-15 00:00:00

abstract：:The Hsp90 chaperone is essential in eukaryotes and activates a large array of client proteins. In contrast, its role is still elusive in bacteria, and only a few Hsp90 bacterial clients are known. Here, we found that Hsp90 is essential in the model bacterium Shewanella oneidensis under heat stress. A genetic screen fo...

journal_title：Cell reports

authors： Honoré FA,Méjean V,Genest O

更新日期：2017-04-25 00:00:00

abstract：:MicroRNA (miRNA) transfer via exosomes may mediate cell-to-cell communication. Interestingly, specific miRNAs are enriched in exosomes in a cell-type-dependent fashion. However, the mechanisms whereby miRNAs are sorted to exosomes and the significance of miRNA transfer to acceptor cells are unclear. We used macrophage...

journal_title：Cell reports

authors： Squadrito ML,Baer C,Burdet F,Maderna C,Gilfillan GD,Lyle R,Ibberson M,De Palma M

更新日期：2014-09-11 00:00:00

abstract：:Whereas hundreds of cells in the mouse embryonic aorta transdifferentiate to hematopoietic cells, only very few establish hematopoietic stem cell (HSC) identity at a single time point. The Gata2 transcription factor is essential for HSC generation and function. In contrast to surface-marker-based cell isolation, Gata2...

journal_title：Cell reports

authors： Vink CS,Calero-Nieto FJ,Wang X,Maglitto A,Mariani SA,Jawaid W,Göttgens B,Dzierzak E

更新日期：2020-05-12 00:00:00

abstract：:Cell size control emerges from a regulated balance between the rates of cell growth and division. In bacteria, simple quantitative laws connect cellular growth rate to ribosome abundance. However, it remains poorly understood how translation regulates bacterial cell size and shape under growth perturbations. Here, we ...

journal_title：Cell reports

authors： Serbanescu D,Ojkic N,Banerjee S

更新日期：2020-09-22 00:00:00

abstract：:Activation of the transcription factor NF-κB is essential for innate immune function and requires strict regulation. The micronutrient zinc modulates proper host defense, and zinc deficiency is associated with elevated inflammation and worse outcomes in response to bacterial infection and sepsis. Previous studies sugg...

journal_title：Cell reports

authors： Liu MJ,Bao S,Gálvez-Peralta M,Pyle CJ,Rudawsky AC,Pavlovicz RE,Killilea DW,Li C,Nebert DW,Wewers MD,Knoell DL

更新日期：2013-02-21 00:00:00

abstract：:Color is continuous, yet we group colors into discrete categories associated with color names (e.g., yellow, blue). Color categorization is a case in point in the debate on how language shapes human cognition. Evidence suggests that color categorization depends on top-down input from the language system to the visual ...

journal_title：Cell reports

authors： Siuda-Krzywicka K,Witzel C,Chabani E,Taga M,Coste C,Cools N,Ferrieux S,Cohen L,Seidel Malkinson T,Bartolomeo P

更新日期：2019-09-03 00:00:00

abstract：:Antiangiogenic drugs are used clinically for treatment of renal cell carcinoma (RCC) as a standard first-line treatment. Nevertheless, these agents primarily serve to stabilize disease, and resistance eventually develops concomitant with progression. Here, we implicate metabolic symbiosis between tumor cells distal an...

journal_title：Cell reports

authors： Jiménez-Valerio G,Martínez-Lozano M,Bassani N,Vidal A,Ochoa-de-Olza M,Suárez C,García-Del-Muro X,Carles J,Viñals F,Graupera M,Indraccolo S,Casanovas O

更新日期：2016-05-10 00:00:00

abstract：:Coordinate control of T cell proliferation, survival, and differentiation are essential for host protection from pathogens and cancer. Long-lived memory cells, whose precursors are formed during the initial immunological insult, provide protection from future encounters, and their generation is the goal of many vaccin...

journal_title：Cell reports

authors： Gagnon JD,Kageyama R,Shehata HM,Fassett MS,Mar DJ,Wigton EJ,Johansson K,Litterman AJ,Odorizzi P,Simeonov D,Laidlaw BJ,Panduro M,Patel S,Jeker LT,Feeney ME,McManus MT,Marson A,Matloubian M,Sanjabi S,Ansel KM

更新日期：2019-08-20 00:00:00

abstract：:DNA methylation plays crucial roles in chromatin structure and gene expression. Aberrant DNA methylation patterns, including global hypomethylation and regional hypermethylation, are associated with cancer and implicated in oncogenic events. How DNA methylation is regulated in developmental and cellular processes and ...

journal_title：Cell reports

authors： Veland N,Hardikar S,Zhong Y,Gayatri S,Dan J,Strahl BD,Rothbart SB,Bedford MT,Chen T

更新日期：2017-12-19 00:00:00

abstract：:The mechanisms dictating whether a cell proliferates or differentiates have undergone intense scrutiny, but they remain poorly understood. Here, we report that UPF1, a central component in the nonsense-mediated RNA decay (NMD) pathway, plays a key role in this decision by promoting the proliferative, undifferentiated ...

journal_title：Cell reports

authors： Lou CH,Shao A,Shum EY,Espinoza JL,Huang L,Karam R,Wilkinson MF

更新日期：2014-02-27 00:00:00

abstract：:Long-lasting forms of synaptic plasticity such as synaptic scaling are critically dependent on transcription. Activity-dependent transcriptional dynamics in neurons, however, remain incompletely characterized because most previous efforts relied on measurement of steady-state mRNAs. Here, we use nascent RNA sequencing...

journal_title：Cell reports

authors： Garay PM,Chen A,Tsukahara T,Rodríguez Díaz JC,Kohen R,Althaus JC,Wallner MA,Giger RJ,Jones KS,Sutton MA,Iwase S

更新日期：2020-08-11 00:00:00

abstract：:Piwi-interacting RNAs (piRNAs), a class of 26- to 32-nt non-coding RNAs (ncRNAs), function in germline development, transposon silencing, and epigenetic regulation. We performed deep sequencing and annotation of untreated and periodate-treated small RNA cDNA libraries from human fetal and adult germline and reference ...

journal_title：Cell reports

authors： Williams Z,Morozov P,Mihailovic A,Lin C,Puvvula PK,Juranek S,Rosenwaks Z,Tuschl T

更新日期：2015-10-27 00:00:00

abstract：:Bin-Amphiphysin-Rvs (BAR) domain proteins are central regulators of many cellular processes involving membrane dynamics. BAR domains sculpt phosphoinositide-rich membranes to generate membrane protrusions or invaginations. Here, we report that, in addition to regulating membrane geometry, BAR domains can generate extr...

journal_title：Cell reports

authors： Zhao H,Michelot A,Koskela EV,Tkach V,Stamou D,Drubin DG,Lappalainen P

更新日期：2013-09-26 00:00:00

abstract：:Pre-implantation embryo development is an intricate and precisely regulated process orchestrated by maternally inherited proteins and newly synthesized proteins following zygotic genome activation. Although genomic and transcriptomic studies have enriched our understanding of the genetic programs underlying this proce...

journal_title：Cell reports

authors： Gao Y,Liu X,Tang B,Li C,Kou Z,Li L,Liu W,Wu Y,Kou X,Li J,Zhao Y,Yin J,Wang H,Chen S,Liao L,Gao S

更新日期：2017-12-26 00:00:00

abstract：:Exercise has been argued to enhance cognitive function and slow progressive neurodegenerative disease. Although exercise promotes neurogenesis, oligodendrogenesis and adaptive myelination are also significant contributors to brain repair and brain health. Nonetheless, the molecular details underlying these effects rem...

journal_title：Cell reports

authors： Alvarez-Saavedra M,De Repentigny Y,Yang D,O'Meara RW,Yan K,Hashem LE,Racacho L,Ioshikhes I,Bulman DE,Parks RJ,Kothary R,Picketts DJ

更新日期：2016-10-11 00:00:00

abstract：:GABAergic synapses in brain circuits generate inhibitory output signals with submillisecond latency and temporal precision. Whether the molecular identity of the release sensor contributes to these signaling properties remains unclear. Here, we examined the Ca2+ sensor of exocytosis at GABAergic basket cell (BC) to Pu...

journal_title：Cell reports

authors： Chen C,Arai I,Satterfield R,Young SM Jr,Jonas P

更新日期：2017-01-17 00:00:00

abstract：:Dynamic nuclear SUMO modifications play essential roles in orchestrating cellular responses to proteotoxic stress, DNA damage, and DNA virus infection. Here, we describe a non-canonical host SUMOylation response to the nuclear-replicating RNA pathogen, influenza virus, and identify viral RNA polymerase activity as a m...

journal_title：Cell reports

authors： Domingues P,Golebiowski F,Tatham MH,Lopes AM,Taggart A,Hay RT,Hale BG

更新日期：2015-11-17 00:00:00