Abstract：
:As the key effector in the Hippo pathway, YAP was identified as an oncoprotein whose expression is elevated in various human cancers. However, the development of potentially therapeutic compounds targeting YAP has been slow and limited. Here, we find that tankyrase inhibitors suppress YAP activity. This effect is mediated by anigomotin (AMOT) family proteins. Tankyrases associate with AMOT family proteins and promote their degradation through E3 ligase RNF146. By antagonizing tankyrase activity, tankyrase inhibitors stabilize AMOT family proteins, thereby suppressing YAP oncogenic functions. Together, our studies not only demonstrate the tankyrase-RNF146-AMOT axis as an upstream pathway regulating YAP but also reveal a therapeutic opportunity in targeting YAP for cancer treatment.
journal_name
Cell Repjournal_title
Cell reportsauthors
Wang W,Li N,Li X,Tran MK,Han X,Chen Jdoi
10.1016/j.celrep.2015.09.014subject
Has Abstractpub_date
2015-10-20 00:00:00pages
524-532issue
3issn
2211-1247pii
S2211-1247(15)01025-6journal_volume
13pub_type
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