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Roles of H3K27me2 and H3K27me3 Examined during Fate Specification of Embryonic Stem Cells.

Abstract：

:The polycomb repressive complex 2 (PRC2) methylates lysine 27 of histone H3 (H3K27) through its catalytic subunit Ezh2. PRC2-mediated di- and tri-methylation (H3K27me2/H3K27me3) have been interchangeably associated with gene repression. However, it remains unclear whether these two degrees of H3K27 methylation have different functions. In this study, we have generated isogenic mouse embryonic stem cells (ESCs) with a modified H3K27me2/H3K27me3 ratio. Our findings document dynamic developmental control in the genomic distribution of H3K27me2 and H3K27me3 at regulatory regions in ESCs. They also reveal that modifying the ratio of H3K27me2 and H3K27me3 is sufficient for the acquisition and repression of defined cell lineage transcriptional programs and phenotypes and influences induction of the ESC ground state.

journal_name

Cell Rep

journal_title

Cell reports

authors

Juan AH,Wang S,Ko KD,Zare H,Tsai PF,Feng X,Vivanco KO,Ascoli AM,Gutierrez-Cruz G,Krebs J,Sidoli S,Knight AL,Pedersen RA,Garcia BA,Casellas R,Zou J,Sartorelli V

doi

10.1016/j.celrep.2016.09.087

subject

Has Abstract

pub_date

2016-10-25 00:00:00

pages

1369-1382

issue

5

issn

2211-1247

pii

S2211-1247(16)31363-8

journal_volume

17

pub_type

杂志文章

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