Abstract：
:Immune cells can metabolize glucose, amino acids, and fatty acids (FAs) to generate energy. The roles of different FA species and their impacts on humoral immunity remain poorly understood. Here, we report that proliferating B cells require monounsaturated FAs (MUFAs) to maintain mitochondrial metabolism and mTOR activity and to prevent excessive autophagy and endoplasmic reticulum (ER) stress. Furthermore, B cell-extrinsic stearoyl-CoA desaturase (SCD) activity generates MUFA to support early B cell development and germinal center (GC) formation in vivo during immunization and influenza infection. Thus, SCD-mediated MUFA production is critical for humoral immunity.
journal_name
Cell Repjournal_title
Cell reportsauthors
Zhou X,Zhu X,Li C,Li Y,Ye Z,Shapiro VS,Copland JA 3rd,Hitosugi T,Bernlohr DA,Sun J,Zeng Hdoi
10.1016/j.celrep.2020.108601subject
Has Abstractpub_date
2021-01-05 00:00:00pages
108601issue
1issn
2211-1247pii
S2211-1247(20)31590-4journal_volume
34pub_type
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