当前位置： SCI文献检索 > Cell Reports期刊下所有文献 > The Mutational Landscape of Circulating Tumor Cells in Multiple Myeloma.

The Mutational Landscape of Circulating Tumor Cells in Multiple Myeloma.

Abstract：

:The development of sensitive and non-invasive "liquid biopsies" presents new opportunities for longitudinal monitoring of tumor dissemination and clonal evolution. The number of circulating tumor cells (CTCs) is prognostic in multiple myeloma (MM), but there is little information on their genetic features. Here, we have analyzed the genomic landscape of CTCs from 29 MM patients, including eight cases with matched/paired bone marrow (BM) tumor cells. Our results show that 100% of clonal mutations in patient BM were detected in CTCs and that 99% of clonal mutations in CTCs were present in BM MM. These include typical driver mutations in MM such as in KRAS, NRAS, or BRAF. These data suggest that BM and CTC samples have similar clonal structures, as discordances between the two were restricted to subclonal mutations. Accordingly, our results pave the way for potentially less invasive mutation screening of MM patients through characterization of CTCs.

journal_name

Cell Rep

journal_title

Cell reports

authors

Mishima Y,Paiva B,Shi J,Park J,Manier S,Takagi S,Massoud M,Perilla-Glen A,Aljawai Y,Huynh D,Roccaro AM,Sacco A,Capelletti M,Detappe A,Alignani D,Anderson KC,Munshi NC,Prosper F,Lohr JG,Ha G,Freeman SS,Van Allen

doi

10.1016/j.celrep.2017.03.025

subject

Has Abstract

pub_date

2017-04-04 00:00:00

pages

218-224

issue

1

issn

2211-1247

pii

S2211-1247(17)30357-1

journal_volume

19

pub_type

杂志文章

相关文献

Cell Reports文献大全
  • FMRP-PKA Activity Negative Feedback Regulates RNA Binding-Dependent Fibrillation in Brain Learning and Memory Circuitry.

    abstract：:Fragile X mental retardation protein (FMRP) promotes cyclic AMP (cAMP) signaling. Using an in vivo protein kinase A activity sensor (PKA-SPARK), we find that Drosophila FMRP (dFMRP) and human FMRP (hFMRP) enhance PKA activity in a central brain learning and memory center. Increasing neuronal PKA activity suppresses FM...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2020.108266

    authors： Sears JC,Broadie K

    更新日期：2020-10-13 00:00:00

  • Telomere Recognition and Assembly Mechanism of Mammalian Shelterin.

    abstract：:Shelterin is a six-subunit protein complex that plays crucial roles in telomere length regulation, protection, and maintenance. Although several shelterin subunits have been studied in vitro, the biochemical properties of the fully assembled shelterin complex are not well defined. Here, we characterize shelterin using...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2016.12.005

    authors： Erdel F,Kratz K,Willcox S,Griffith JD,Greene EC,de Lange T

    更新日期：2017-01-03 00:00:00

  • FAD Regulates CRYPTOCHROME Protein Stability and Circadian Clock in Mice.

    abstract：:The circadian clock generates biological rhythms of metabolic and physiological processes, including the sleep-wake cycle. We previously identified a missense mutation in the flavin adenine dinucleotide (FAD) binding pocket of CRYPTOCHROME2 (CRY2), a clock protein that causes human advanced sleep phase. This prompted ...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2017.03.041

    authors： Hirano A,Braas D,Fu YH,Ptáček LJ

    更新日期：2017-04-11 00:00:00

  • Presenilin deficiency or lysosomal inhibition enhances Wnt signaling through relocalization of GSK3 to the late-endosomal compartment.

    abstract：:Sustained canonical Wnt signaling requires the inhibition of glycogen synthase kinase 3 (GSK3) activity by sequestration of GSK3 inside multivesicular endosomes (MVEs). Here, we show that Wnt signaling is increased by the lysosomal inhibitor chloroquine, which causes accumulation of MVEs. A similar MVE expansion and i...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2012.09.026

    authors： Dobrowolski R,Vick P,Ploper D,Gumper I,Snitkin H,Sabatini DD,De Robertis EM

    更新日期：2012-11-29 00:00:00

  • Proviral silencing in embryonic cells is regulated by Yin Yang 1.

    abstract：:Embryonic cells transcriptionally repress the expression of endogenous and exogenous retroelements. Trim28, a key player in this silencing, is known to act in a large DNA-bound complex, but the other components of the complex are not fully characterized. Here, we show that the zinc finger protein Yin Yang 1 (YY1) is o...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2013.06.003

    authors： Schlesinger S,Lee AH,Wang GZ,Green L,Goff SP

    更新日期：2013-07-11 00:00:00

  • A RhoA-FRET Biosensor Mouse for Intravital Imaging in Normal Tissue Homeostasis and Disease Contexts.

    abstract：:The small GTPase RhoA is involved in a variety of fundamental processes in normal tissue. Spatiotemporal control of RhoA is thought to govern mechanosensing, growth, and motility of cells, while its deregulation is associated with disease development. Here, we describe the generation of a RhoA-fluorescence resonance e...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2017.09.022

    authors： Nobis M,Herrmann D,Warren SC,Kadir S,Leung W,Killen M,Magenau A,Stevenson D,Lucas MC,Reischmann N,Vennin C,Conway JRW,Boulghourjian A,Zaratzian A,Law AM,Gallego-Ortega D,Ormandy CJ,Walters SN,Grey ST,Bailey J,Chta

    更新日期：2017-10-03 00:00:00

  • Mutations in Craniosynostosis Patients Cause Defective Interleukin-11 Receptor Maturation and Drive Craniosynostosis-like Disease in Mice.

    abstract：:Premature closure of the sutures that connect the cranial bones during development of the mammalian skull results in a phenotype called craniosynostosis. Recently, several craniosynostosis patients with missense mutations within the gene encoding the interleukin-11 receptor (IL-11R) have been described, but the underl...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2018.09.005

    authors： Agthe M,Brügge J,Garbers Y,Wandel M,Kespohl B,Arnold P,Flynn CM,Lokau J,Aparicio-Siegmund S,Bretscher C,Rose-John S,Waetzig GH,Putoczki T,Grötzinger J,Garbers C

    更新日期：2018-10-02 00:00:00

  • FANCD2 binds CtIP and regulates DNA-end resection during DNA interstrand crosslink repair.

    abstract：:The Fanconi anemia (FA) pathway is critically involved in the maintenance of hematopoietic stem cells and the suppression of carcinogenesis. A key FA protein, FANCD2, is monoubiquitinated and accumulates in chromatin in response to DNA interstrand crosslinks (ICLs), where it coordinates DNA repair through mechanisms t...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2014.04.005

    authors： Unno J,Itaya A,Taoka M,Sato K,Tomida J,Sakai W,Sugasawa K,Ishiai M,Ikura T,Isobe T,Kurumizaka H,Takata M

    更新日期：2014-05-22 00:00:00

  • Ecto-ATPase CD39 Inactivates Isoprenoid-Derived Vγ9Vδ2 T Cell Phosphoantigens.

    abstract：:In humans, Vγ9Vδ2 T cells respond to self and pathogen-associated, diphosphate-containing isoprenoids, also known as phosphoantigens (pAgs). However, activation and homeostasis of Vγ9Vδ2 T cells remain incompletely understood. Here, we show that pAgs induced expression of the ecto-ATPase CD39, which, however, not only...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2016.06.009

    authors： Gruenbacher G,Gander H,Rahm A,Idzko M,Nussbaumer O,Thurnher M

    更新日期：2016-07-12 00:00:00

  • Fungicidal drugs induce a common oxidative-damage cellular death pathway.

    abstract：:Amphotericin, miconazole, and ciclopirox are antifungal agents from three different drug classes that can effectively kill planktonic yeast, yet their complete fungicidal mechanisms are not fully understood. Here, we employ a systems biology approach to identify a common oxidative-damage cellular death pathway trigger...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2012.12.021

    authors： Belenky P,Camacho D,Collins JJ

    更新日期：2013-02-21 00:00:00

  • TNF-α-Induced microRNAs Control Dystrophin Expression in Becker Muscular Dystrophy.

    abstract：:The amount and distribution of dystrophin protein in myofibers and muscle is highly variable in Becker muscular dystrophy and in exon-skipping trials for Duchenne muscular dystrophy. Here, we investigate a molecular basis for this variability. In muscle from Becker patients sharing the same exon 45-47 in-frame deletio...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2015.07.066

    authors： Fiorillo AA,Heier CR,Novak JS,Tully CB,Brown KJ,Uaesoontrachoon K,Vila MC,Ngheim PP,Bello L,Kornegay JN,Angelini C,Partridge TA,Nagaraju K,Hoffman EP

    更新日期：2015-09-08 00:00:00

  • A Regulation Loop between YAP and NR4A1 Balances Cell Proliferation and Apoptosis.

    abstract：:The Hippo signaling pathway maintains organ size and tissue homeostasis via orchestration of cell proliferation and apoptosis. How this pathway triggers cell apoptosis remains largely unexplored. Here, we identify NR4A1 as a target of the Hippo pathway that mediates the pro-apoptotic and anti-tumor effects of the Hipp...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2020.108284

    authors： He L,Yuan L,Yu W,Sun Y,Jiang D,Wang X,Feng X,Wang Z,Xu J,Yang R,Zhang W,Feng H,Chen HZ,Zeng YA,Hui L,Wu Q,Zhang Y,Zhang L

    更新日期：2020-10-20 00:00:00

  • Pericytes Stimulate Oligodendrocyte Progenitor Cell Differentiation during CNS Remyelination.

    abstract：:The role of the neurovascular niche in CNS myelin regeneration is incompletely understood. Here, we show that, upon demyelination, CNS-resident pericytes (PCs) proliferate, and parenchymal non-vessel-associated PC-like cells (PLCs) rapidly develop. During remyelination, mature oligodendrocytes were found in close prox...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2017.08.007

    authors： De La Fuente AG,Lange S,Silva ME,Gonzalez GA,Tempfer H,van Wijngaarden P,Zhao C,Di Canio L,Trost A,Bieler L,Zaunmair P,Rotheneichner P,O'Sullivan A,Couillard-Despres S,Errea O,Mäe MA,Andrae J,He L,Keller A,Bátiz LF

    更新日期：2017-08-22 00:00:00

  • Inhibition of ATPIF1 ameliorates severe mitochondrial respiratory chain dysfunction in mammalian cells.

    abstract：:Mitochondrial respiratory chain disorders are characterized by loss of electron transport chain (ETC) activity. Although the causes of many such diseases are known, there is a lack of effective therapies. To identify genes that confer resistance to severe ETC dysfunction when inactivated, we performed a genome-wide ge...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2014.02.046

    authors： Chen WW,Birsoy K,Mihaylova MM,Snitkin H,Stasinski I,Yucel B,Bayraktar EC,Carette JE,Clish CB,Brummelkamp TR,Sabatini DD,Sabatini DM

    更新日期：2014-04-10 00:00:00

  • Importin α and vNEBD Control Meiotic Spindle Disassembly in Fission Yeast.

    abstract：:In metazoans, the nuclear envelope (NE) breakdown (NEBD) occurs during "open" mitosis and meiosis. In the fission yeast Schizosaccharomyces pombe, the mitosis and the first meiotic division (MI) are "closed," during which the NE is maintained. Intriguingly, during the second meiotic division (MII), the NE is also main...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2018.03.073

    authors： Flor-Parra I,Iglesias-Romero AB,Salas-Pino S,Lucena R,Jimenez J,Daga RR

    更新日期：2018-04-24 00:00:00

  • Activation of Mevalonate Pathway via LKB1 Is Essential for Stability of Treg Cells.

    abstract：:The function of regulatory T (Treg) cells depends on lipid oxidation. However, the molecular mechanism by which Treg cells maintain lipid metabolism after activation remains elusive. Liver kinase B1 (LKB1) acts as a coordinator by linking cellular metabolism to substrate AMP-activated protein kinase (AMPK). We show th...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2019.05.020

    authors： Timilshina M,You Z,Lacher SM,Acharya S,Jiang L,Kang Y,Kim JA,Chang HW,Kim KJ,Park B,Song JH,Ko HJ,Park YY,Ma MJ,Nepal MR,Jeong TC,Chung Y,Waisman A,Chang JH

    更新日期：2019-06-04 00:00:00

  • Iterative Single-Cell Analyses Define the Transcriptome of the First Functional Hematopoietic Stem Cells.

    abstract：:Whereas hundreds of cells in the mouse embryonic aorta transdifferentiate to hematopoietic cells, only very few establish hematopoietic stem cell (HSC) identity at a single time point. The Gata2 transcription factor is essential for HSC generation and function. In contrast to surface-marker-based cell isolation, Gata2...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2020.107627

    authors： Vink CS,Calero-Nieto FJ,Wang X,Maglitto A,Mariani SA,Jawaid W,Göttgens B,Dzierzak E

    更新日期：2020-05-12 00:00:00

  • Local Resting Ca2+ Controls the Scale of Astroglial Ca2+ Signals.

    abstract：:Astroglia regulate neurovascular coupling while engaging in signal exchange with neurons. The underlying cellular machinery is thought to rely on astrocytic Ca2+ signals, but what controls their amplitude and waveform is poorly understood. Here, we employ time-resolved two-photon excitation fluorescence imaging in acu...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2020.02.043

    authors： King CM,Bohmbach K,Minge D,Delekate A,Zheng K,Reynolds J,Rakers C,Zeug A,Petzold GC,Rusakov DA,Henneberger C

    更新日期：2020-03-10 00:00:00

  • The circadian molecular clock regulates adult hippocampal neurogenesis by controlling the timing of cell-cycle entry and exit.

    abstract：:The subgranular zone (SGZ) of the adult hippocampus contains a pool of quiescent neural progenitor cells (QNPs) that are capable of entering the cell cycle and producing newborn neurons. The mechanisms that control the timing and extent of adult neurogenesis are not well understood. Here, we show that QNPs of the adul...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2013.10.037

    authors： Bouchard-Cannon P,Mendoza-Viveros L,Yuen A,Kærn M,Cheng HY

    更新日期：2013-11-27 00:00:00

  • Interferon Gamma Mediates Hematopoietic Stem Cell Activation and Niche Relocalization through BST2.

    abstract：:During chronic infection, the inflammatory cytokine interferon gamma (IFNγ) damages hematopoietic stem cells (HSCs) by disrupting quiescence and promoting excessive terminal differentiation. However, the mechanism by which IFNγ hinders HSC quiescence remains undefined. Using intravital 3-dimensional microscopy, we fin...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2020.108530

    authors： Florez MA,Matatall KA,Jeong Y,Ortinau L,Shafer PW,Lynch AM,Jaksik R,Kimmel M,Park D,King KY

    更新日期：2020-12-22 00:00:00

  • Clarifying the Translational Pausing Landscape in Bacteria by Ribosome Profiling.

    abstract：:The rate of protein synthesis varies according to the mRNA sequence in ways that affect gene expression. Global analysis of translational pausing is now possible with ribosome profiling. Here, we revisit an earlier report that Shine-Dalgarno sequences are the major determinant of translational pausing in bacteria. Usi...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2015.12.073

    authors： Mohammad F,Woolstenhulme CJ,Green R,Buskirk AR

    更新日期：2016-02-02 00:00:00

  • Disruption of Runx1 and Runx3 leads to bone marrow failure and leukemia predisposition due to transcriptional and DNA repair defects.

    abstract：:The RUNX genes encode transcription factors involved in development and human disease. RUNX1 and RUNX3 are frequently associated with leukemias, yet the basis for their involvement in leukemogenesis is not fully understood. Here, we show that Runx1;Runx3 double-knockout (DKO) mice exhibited lethal phenotypes due to bo...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2014.06.046

    authors： Wang CQ,Krishnan V,Tay LS,Chin DW,Koh CP,Chooi JY,Nah GS,Du L,Jacob B,Yamashita N,Lai SK,Tan TZ,Mori S,Tanuichi I,Tergaonkar V,Ito Y,Osato M

    更新日期：2014-08-07 00:00:00

  • Lysine-specific demethylase 1 has dual functions as a major regulator of androgen receptor transcriptional activity.

    abstract：:Lysine-Specific Demethylase 1 (LSD1, KDM1A) functions as a transcriptional corepressor through demethylation of histone 3 lysine 4 (H3K4) but has a coactivator function on some genes through mechanisms that are unclear. We show that LSD1, interacting with CoREST, associates with and coactivates androgen receptor (AR) ...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2014.11.008

    authors： Cai C,He HH,Gao S,Chen S,Yu Z,Gao Y,Chen S,Chen MW,Zhang J,Ahmed M,Wang Y,Metzger E,Schüle R,Liu XS,Brown M,Balk SP

    更新日期：2014-12-11 00:00:00

  • A Positive Twist to the Centromeric Nucleosome.

    abstract：:Centromeric nucleosomes are critical for chromosome attachment to the mitotic spindle. In this issue of Cell Reports, Diaz-Ingelmo et al. (2015) propose that the yeast centromeric nucleosome is stabilized by a positively supercoiled loop formed by the sequence-specific CBF3 complex. ...

    journal_title：Cell reports

    pub_type： 评论,杂志文章

    doi：10.1016/j.celrep.2015.10.007

    authors： Ocampo J,Clark DJ

    更新日期：2015-10-27 00:00:00

  • Functional Gene Correction for Cystic Fibrosis in Lung Epithelial Cells Generated from Patient iPSCs.

    abstract：:Lung disease is a major cause of death in the United States, with current therapeutic approaches serving only to manage symptoms. The most common chronic and life-threatening genetic disease of the lung is cystic fibrosis (CF) caused by mutations in the cystic fibrosis transmembrane regulator (CFTR). We have generated...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2015.07.062

    authors： Firth AL,Menon T,Parker GS,Qualls SJ,Lewis BM,Ke E,Dargitz CT,Wright R,Khanna A,Gage FH,Verma IM

    更新日期：2015-09-01 00:00:00

  • Antagonism between retinoic acid and fibroblast growth factor signaling during limb development.

    abstract：:The vitamin A metabolite retinoic acid (RA) provides patterning information during vertebrate embryogenesis, but the mechanism through which RA influences limb development is unclear. During patterning of the limb proximodistal axis (upper limb to digits), avian studies suggest that a proximal RA signal generated in t...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2013.03.036

    authors： Cunningham TJ,Zhao X,Sandell LL,Evans SM,Trainor PA,Duester G

    更新日期：2013-05-30 00:00:00

  • Principles of Membrane Adaptation Revealed through Environmentally Induced Bacterial Lipidome Remodeling.

    abstract：:Cells, from microbes to mammals, adapt their membrane lipid composition in response to environmental changes to maintain optimal properties. Global patterns of lipidome remodeling are poorly understood, particularly in organisms with simple lipid compositions that can provide insight into fundamental principles of mem...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2020.108165

    authors： Chwastek G,Surma MA,Rizk S,Grosser D,Lavrynenko O,Rucińska M,Jambor H,Sáenz J

    更新日期：2020-09-22 00:00:00

  • Severe Malaria Infections Impair Germinal Center Responses by Inhibiting T Follicular Helper Cell Differentiation.

    abstract：:Naturally acquired immunity to malaria develops only after years of repeated exposure to Plasmodium parasites. Despite the key role antibodies play in protection, the cellular processes underlying the slow acquisition of immunity remain unknown. Using mouse models, we show that severe malaria infection inhibits the es...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2015.12.006

    authors： Ryg-Cornejo V,Ioannidis LJ,Ly A,Chiu CY,Tellier J,Hill DL,Preston SP,Pellegrini M,Yu D,Nutt SL,Kallies A,Hansen DS

    更新日期：2016-01-05 00:00:00

  • Systematic Kinase Inhibitor Profiling Identifies CDK9 as a Synthetic Lethal Target in NUT Midline Carcinoma.

    abstract：:Kinase inhibitors represent the backbone of targeted cancer therapy, yet only a limited number of oncogenic drivers are directly druggable. By interrogating the activity of 1,505 kinase inhibitors, we found that BRD4-NUT-rearranged NUT midline carcinoma (NMC) cells are specifically killed by CDK9 inhibition (CDK9i) an...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2017.08.082

    authors： Brägelmann J,Dammert MA,Dietlein F,Heuckmann JM,Choidas A,Böhm S,Richters A,Basu D,Tischler V,Lorenz C,Habenberger P,Fang Z,Ortiz-Cuaran S,Leenders F,Eickhoff J,Koch U,Getlik M,Termathe M,Sallouh M,Greff Z,Varga Z

    更新日期：2017-09-19 00:00:00

  • HUWE1 ubiquitylates and degrades the RAC activator TIAM1 promoting cell-cell adhesion disassembly, migration, and invasion.

    abstract：:The E3 ubiquitin ligase HUWE1, deregulated in carcinoma, has been implicated in tumor formation. Here, we uncover a role for HUWE1 in cell migration and invasion through degrading the RAC activator TIAM1, implying an additional function in malignant progression. In MDCKII cells in response to HGF, HUWE1 catalyzes TIAM...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2014.12.012

    authors： Vaughan L,Tan CT,Chapman A,Nonaka D,Mack NA,Smith D,Booton R,Hurlstone AF,Malliri A

    更新日期：2015-01-06 00:00:00