当前位置： SCI文献检索 > Cell Reports期刊下所有文献 > TRIM28 Controls a Gene Regulatory Network Based on Endogenous Retroviruses in Human Neural Progenitor Cells.

TRIM28 Controls a Gene Regulatory Network Based on Endogenous Retroviruses in Human Neural Progenitor Cells.

Abstract：

:Endogenous retroviruses (ERVs), which make up 8% of the human genome, have been proposed to participate in the control of gene regulatory networks. In this study, we find a region- and developmental stage-specific expression pattern of ERVs in the developing human brain, which is linked to a transcriptional network based on ERVs. We demonstrate that almost 10,000, primarily primate-specific, ERVs act as docking platforms for the co-repressor protein TRIM28 in human neural progenitor cells, which results in the establishment of local heterochromatin. Thereby, TRIM28 represses ERVs and consequently regulates the expression of neighboring genes. These results uncover a gene regulatory network based on ERVs that participates in control of gene expression of protein-coding transcripts important for brain development.

journal_name

Cell Rep

journal_title

Cell reports

authors

Brattås PL,Jönsson ME,Fasching L,Nelander Wahlestedt J,Shahsavani M,Falk R,Falk A,Jern P,Parmar M,Jakobsson J

doi

10.1016/j.celrep.2016.12.010

subject

Has Abstract

pub_date

2017-01-03 00:00:00

pages

1-11

issue

1

issn

2211-1247

pii

S2211-1247(16)31683-7

journal_volume

18

pub_type

杂志文章

相关文献

Cell Reports文献大全
  • Metallothionein 3 Controls the Phenotype and Metabolic Programming of Alternatively Activated Macrophages.

    abstract：:Alternatively activated (M2) macrophages promote wound healing but weaken antimicrobial defenses. The mechanisms that enforce macrophage divergence and dictate the phenotypic and metabolic characteristics of M2 macrophages remain elusive. We show that alternative activation with interleukin (IL)-4 induces expression o...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2019.05.093

    authors： Chowdhury D,Alrefai H,Landero Figueroa JA,Candor K,Porollo A,Fecher R,Divanovic S,Deepe GS Jr,Subramanian Vignesh K

    更新日期：2019-06-25 00:00:00

  • Enhanced Transcriptional Activity and Mitochondrial Localization of STAT3 Co-induce Axon Regrowth in the Adult Central Nervous System.

    abstract：:Signal transducer and activator of transcription 3 (STAT3) is a transcription factor central to axon regrowth with an enigmatic ability to act in different subcellular regions independently of its transcriptional roles. However, its roles in mature CNS neurons remain unclear. Here, we show that along with nuclear tran...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2016.03.029

    authors： Luo X,Ribeiro M,Bray ER,Lee DH,Yungher BJ,Mehta ST,Thakor KA,Diaz F,Lee JK,Moraes CT,Bixby JL,Lemmon VP,Park KK

    更新日期：2016-04-12 00:00:00

  • Constitutional chromothripsis rearrangements involve clustered double-stranded DNA breaks and nonhomologous repair mechanisms.

    abstract：:Chromothripsis represents a novel phenomenon in the structural variation landscape of cancer genomes. Here, we analyze the genomes of ten patients with congenital disease who were preselected to carry complex chromosomal rearrangements with more than two breakpoints. The rearrangements displayed unanticipated complexi...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2012.05.009

    authors： Kloosterman WP,Tavakoli-Yaraki M,van Roosmalen MJ,van Binsbergen E,Renkens I,Duran K,Ballarati L,Vergult S,Giardino D,Hansson K,Ruivenkamp CA,Jager M,van Haeringen A,Ippel EF,Haaf T,Passarge E,Hochstenbach R,Menten B,

    更新日期：2012-06-28 00:00:00

  • The architecture of yeast DNA polymerase ζ.

    abstract：:DNA polymerase ζ (Polζ) is specialized for the extension step of translesion DNA synthesis (TLS). Despite its central role in maintaining genome integrity, little is known about its overall architecture. Initially identified as a heterodimer of the catalytic subunit Rev3 and the accessory subunit Rev7, yeast Polζ has ...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2013.08.046

    authors： Gómez-Llorente Y,Malik R,Jain R,Choudhury JR,Johnson RE,Prakash L,Prakash S,Ubarretxena-Belandia I,Aggarwal AK

    更新日期：2013-10-17 00:00:00

  • Work Done by Titin Protein Folding Assists Muscle Contraction.

    abstract：:Current theories of muscle contraction propose that the power stroke of a myosin motor is the sole source of mechanical energy driving the sliding filaments of a contracting muscle. These models exclude titin, the largest protein in the human body, which determines the passive elasticity of muscles. Here, we show that...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2016.01.025

    authors： Rivas-Pardo JA,Eckels EC,Popa I,Kosuri P,Linke WA,Fernández JM

    更新日期：2016-02-16 00:00:00

  • The Interaction of the Tumor Suppressor FAM46C with p62 and FNDC3 Proteins Integrates Protein and Secretory Homeostasis.

    abstract：:FAM46C is a non-canonical poly(A) polymerase uniquely mutated in up to 20% of multiple myeloma (MM) patients, implying a tissue-specific tumor suppressor function. Here, we report that FAM46C selectively stabilizes mRNAs encoding endoplasmic reticulum (ER)-targeted proteins, thereby concertedly enhancing the expressio...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2020.108162

    authors： Fucci C,Resnati M,Riva E,Perini T,Ruggieri E,Orfanelli U,Paradiso F,Cremasco F,Raimondi A,Pasqualetto E,Nuvolone M,Rampoldi L,Cenci S,Milan E

    更新日期：2020-09-22 00:00:00

  • MALT1 Phosphorylation Controls Activation of T Lymphocytes and Survival of ABC-DLBCL Tumor Cells.

    abstract：:The CARMA1/CARD11-BCL10-MALT1 (CBM) complex bridges T and B cell antigen receptor (TCR/BCR) ligation to MALT1 protease activation and canonical nuclear factor κB (NF-κB) signaling. Using unbiased mass spectrometry, we discover multiple serine phosphorylation sites in the MALT1 C terminus after T cell activation. Phosp...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2019.09.040

    authors： Gehring T,Erdmann T,Rahm M,Graß C,Flatley A,O'Neill TJ,Woods S,Meininger I,Karayel O,Kutzner K,Grau M,Shinohara H,Lammens K,Feederle R,Hauck SM,Lenz G,Krappmann D

    更新日期：2019-10-22 00:00:00

  • Developmental Origin of Oligodendrocyte Lineage Cells Determines Response to Demyelination and Susceptibility to Age-Associated Functional Decline.

    abstract：:Oligodendrocyte progenitors (OPs) arise from distinct ventral and dorsal domains within the ventricular germinal zones of the embryonic CNS. The functional significance, if any, of these different populations is not known. Using dual-color reporter mice to distinguish ventrally and dorsally derived OPs, we show that, ...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2016.03.069

    authors： Crawford AH,Tripathi RB,Richardson WD,Franklin RJM

    更新日期：2016-04-26 00:00:00

  • The Role of CaV2.1 Channel Facilitation in Synaptic Facilitation.

    abstract：:Activation of CaV2.1 voltage-gated calcium channels is facilitated by preceding calcium entry. Such self-modulatory facilitation is thought to contribute to synaptic facilitation. Using knockin mice with mutated CaV2.1 channels that do not facilitate (Ca IM-AA mice), we surprisingly found that, under conditions of phy...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2019.01.114

    authors： Weyrer C,Turecek J,Niday Z,Liu PW,Nanou E,Catterall WA,Bean BP,Regehr WG

    更新日期：2019-02-26 00:00:00

  • Structures of NS5 Methyltransferase from Zika Virus.

    abstract：:The Zika virus (ZIKV) poses a major public health emergency. To aid in the development of antivirals, we present two high-resolution crystal structures of the ZIKV NS5 methyltransferase: one bound to S-adenosylmethionine (SAM) and the other bound to SAM and 7-methyl guanosine diphosphate (7-MeGpp). We identify feature...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2016.08.091

    authors： Coloma J,Jain R,Rajashankar KR,García-Sastre A,Aggarwal AK

    更新日期：2016-09-20 00:00:00

  • Circulating miRNA Spaceflight Signature Reveals Targets for Countermeasure Development.

    abstract：:We have identified and validated a spaceflight-associated microRNA (miRNA) signature that is shared by rodents and humans in response to simulated, short-duration and long-duration spaceflight. Previous studies have identified miRNAs that regulate rodent responses to spaceflight in low-Earth orbit, and we have confirm...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2020.108448

    authors： Malkani S,Chin CR,Cekanaviciute E,Mortreux M,Okinula H,Tarbier M,Schreurs AS,Shirazi-Fard Y,Tahimic CGT,Rodriguez DN,Sexton BS,Butler D,Verma A,Bezdan D,Durmaz C,MacKay M,Melnick A,Meydan C,Li S,Garrett-Bakelman F,

    更新日期：2020-12-08 00:00:00

  • The Apolipoprotein M/S1P Axis Controls Triglyceride Metabolism and Brown Fat Activity.

    abstract：:Apolipoprotein M (apoM) is the carrier of sphingosine-1-phosphate (S1P) in plasma high-density lipoproteins. S1P is a bioactive lipid interacting with five receptors (S1P1-5). We show that lack of apoM in mice increases the amount of brown adipose tissue (BAT), accelerates the clearance of postprandial triglycerides, ...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2017.12.029

    authors： Christoffersen C,Federspiel CK,Borup A,Christensen PM,Madsen AN,Heine M,Nielsen CH,Kjaer A,Holst B,Heeren J,Nielsen LB

    更新日期：2018-01-02 00:00:00

  • MYO6 Regulates Spatial Organization of Signaling Endosomes Driving AKT Activation and Actin Dynamics.

    abstract：:APPL1- and RAB5-positive signaling endosomes play a crucial role in the activation of AKT in response to extracellular stimuli. Myosin VI (MYO6) and two of its cargo adaptor proteins, GIPC and TOM1/TOM1L2, localize to these peripheral endosomes and mediate endosome association with cortical actin filaments. Loss of MY...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2017.05.048

    authors： Masters TA,Tumbarello DA,Chibalina MV,Buss F

    更新日期：2017-06-06 00:00:00

  • Spatiotemporal Control of Lipid Conversion, Actin-Based Mechanical Forces, and Curvature Sensors during Clathrin/AP-1-Coated Vesicle Biogenesis.

    abstract：:Clathrin/adaptor protein-1-coated carriers connect the secretory and the endocytic pathways. Carrier biogenesis relies on distinct protein networks changing membrane shape at the trans-Golgi network, each regulating coat assembly, F-actin-based mechanical forces, or the biophysical properties of lipid bilayers. How th...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2017.08.013

    authors： Anitei M,Stange C,Czupalla C,Niehage C,Schuhmann K,Sala P,Czogalla A,Pursche T,Coskun Ü,Shevchenko A,Hoflack B

    更新日期：2017-08-29 00:00:00

  • Systems-level response to point mutations in a core metabolic enzyme modulates genotype-phenotype relationship.

    abstract：:Linking the molecular effects of mutations to fitness is central to understanding evolutionary dynamics. Here, we establish a quantitative relation between the global effect of mutations on the E. coli proteome and bacterial fitness. We created E. coli strains with specific destabilizing mutations in the chromosomal f...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2015.03.051

    authors： Bershtein S,Choi JM,Bhattacharyya S,Budnik B,Shakhnovich E

    更新日期：2015-04-28 00:00:00

  • Two Differential Binding Mechanisms of FG-Nucleoporins and Nuclear Transport Receptors.

    abstract：:Phenylalanine-glycine-rich nucleoporins (FG-Nups) are intrinsically disordered proteins, constituting the selective barrier of the nuclear pore complex (NPC). Previous studies showed that nuclear transport receptors (NTRs) were found to interact with FG-Nups by forming an "archetypal-fuzzy" complex through the rapid f...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2018.03.022

    authors： Tan PS,Aramburu IV,Mercadante D,Tyagi S,Chowdhury A,Spitz D,Shammas SL,Gräter F,Lemke EA

    更新日期：2018-03-27 00:00:00

  • A replicase clamp-binding dynamin-like protein promotes colocalization of nascent DNA strands and equipartitioning of chromosomes in E. coli.

    abstract：:In Escherichia coli, bidirectional chromosomal replication is accompanied by the colocalization of sister replication forks. However, the biological significance of this mechanism and the key factors involved are still largely unknown. In this study, we found that a protein, termed CrfC, helps sustain the colocalizati...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2013.07.040

    authors： Ozaki S,Matsuda Y,Keyamura K,Kawakami H,Noguchi Y,Kasho K,Nagata K,Masuda T,Sakiyama Y,Katayama T

    更新日期：2013-09-12 00:00:00

  • Fusion of Reprogramming Factors Alters the Trajectory of Somatic Lineage Conversion.

    abstract：:Simultaneous expression of Oct4, Klf4, Sox2, and cMyc induces pluripotency in somatic cells (iPSCs). Replacing Oct4 with the neuro-specific factor Brn4 leads to transdifferentiation of fibroblasts into induced neural stem cells (iNSCs). However, Brn4 was recently found to induce transient acquisition of pluripotency b...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2019.03.023

    authors： Velychko S,Kang K,Kim SM,Kwak TH,Kim KP,Park C,Hong K,Chung C,Hyun JK,MacCarthy CM,Wu G,Schöler HR,Han DW

    更新日期：2019-04-02 00:00:00

  • Regulation of S100A8 Stability by RNF5 in Intestinal Epithelial Cells Determines Intestinal Inflammation and Severity of Colitis.

    abstract：:Inflammatory bowel disease (IBD) is prevalent, but the mechanisms underlying disease development remain elusive. We identify a role for the E3 ubiquitin ligase RNF5 in IBD. Intestinal epithelial cells (IECs) express a high level of RNF5, while the colon of Rnf5-/- mice exhibits activated dendritic cells and intrinsic ...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2018.08.057

    authors： Fujita Y,Khateb A,Li Y,Tinoco R,Zhang T,Bar-Yoseph H,Tam MA,Chowers Y,Sabo E,Gerassy-Vainberg S,Starosvetsky E,James B,Brown K,Shen-Orr SS,Bradley LM,Tessier PA,Ronai ZA

    更新日期：2018-09-18 00:00:00

  • Molecular basis for the ribosome functioning as an L-tryptophan sensor.

    abstract：:Elevated levels of the free amino acid L-tryptophan (L-Trp) trigger expression of the tryptophanase tnaCAB operon in E. coli. Activation depends on tryptophan-dependent ribosomal stalling during translation of the upstream TnaC peptide. Here, we present a cryoelectron microscopy (cryo-EM) reconstruction at 3.8 Å resol...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2014.09.011

    authors： Bischoff L,Berninghausen O,Beckmann R

    更新日期：2014-10-23 00:00:00

  • Data-Driven Modeling of Intracellular Auxin Fluxes Indicates a Dominant Role of the ER in Controlling Nuclear Auxin Uptake.

    abstract：:In plants, the phytohormone auxin acts as a master regulator of developmental processes and environmental responses. The best characterized process in the auxin regulatory network occurs at the subcellular scale, wherein auxin mediates signal transduction into transcriptional programs by triggering the degradation of ...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2018.02.074

    authors： Middleton AM,Dal Bosco C,Chlap P,Bensch R,Harz H,Ren F,Bergmann S,Wend S,Weber W,Hayashi KI,Zurbriggen MD,Uhl R,Ronneberger O,Palme K,Fleck C,Dovzhenko A

    更新日期：2018-03-13 00:00:00

  • Elongation-Competent Pauses Govern the Fidelity of a Viral RNA-Dependent RNA Polymerase.

    abstract：:RNA viruses have specific mutation rates that balance the conflicting needs of an evolutionary response to host antiviral defenses and avoidance of the error catastrophe. While most mutations are known to originate in replication errors, difficulties of capturing the underlying dynamics have left the mechanochemical b...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2015.01.031

    authors： Dulin D,Vilfan ID,Berghuis BA,Hage S,Bamford DH,Poranen MM,Depken M,Dekker NH

    更新日期：2015-02-17 00:00:00

  • A Simple Grammar Defines Activating and Repressing cis-Regulatory Elements in Photoreceptors.

    abstract：:Transcription factors often activate and repress different target genes in the same cell. How activation and repression are encoded by different arrangements of transcription factor binding sites in cis-regulatory elements is poorly understood. We investigated how sites for the transcription factor CRX encode both act...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2016.09.066

    authors： White MA,Kwasnieski JC,Myers CA,Shen SQ,Corbo JC,Cohen BA

    更新日期：2016-10-25 00:00:00

  • SUMOylation of Psmd1 controls Adrm1 interaction with the proteasome.

    abstract：:SUMOylation is the covalent conjugation of SUMO polypeptides to cellular target proteins. Psmd1 is a subunit of the proteasomal 19S regulatory particle that acts as a docking site for Adrm1, another proteasome subunit that recruits ubiquitinated substrates for proteolysis. Here, we show that the SUMO deconjugating enz...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2014.05.009

    authors： Ryu H,Gygi SP,Azuma Y,Arnaoutov A,Dasso M

    更新日期：2014-06-26 00:00:00

  • Parabrachial Interleukin-6 Reduces Body Weight and Food Intake and Increases Thermogenesis to Regulate Energy Metabolism.

    abstract：:Chronic low-grade inflammation and increased serum levels of the cytokine IL-6 accompany obesity. For brain-produced IL-6, the mechanisms by which it controls energy balance and its role in obesity remain unclear. Here, we show that brain-produced IL-6 is decreased in obese mice and rats in a neuroanatomically and sex...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2019.02.044

    authors： Mishra D,Richard JE,Maric I,Porteiro B,Häring M,Kooijman S,Musovic S,Eerola K,López-Ferreras L,Peris E,Grycel K,Shevchouk OT,Micallef P,Olofsson CS,Wernstedt Asterholm I,Grill HJ,Nogueiras R,Skibicka KP

    更新日期：2019-03-12 00:00:00

  • HITS-CLIP and integrative modeling define the Rbfox splicing-regulatory network linked to brain development and autism.

    abstract：:The RNA binding proteins Rbfox1/2/3 regulate alternative splicing in the nervous system, and disruption of Rbfox1 has been implicated in autism. However, comprehensive identification of functional Rbfox targets has been challenging. Here, we perform HITS-CLIP for all three Rbfox family members in order to globally map...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2014.02.005

    authors： Weyn-Vanhentenryck SM,Mele A,Yan Q,Sun S,Farny N,Zhang Z,Xue C,Herre M,Silver PA,Zhang MQ,Krainer AR,Darnell RB,Zhang C

    更新日期：2014-03-27 00:00:00

  • Peripheral Elevation of a Klotho Fragment Enhances Brain Function and Resilience in Young, Aging, and α-Synuclein Transgenic Mice.

    abstract：:Cognitive dysfunction and decreased mobility from aging and neurodegenerative conditions, such as Parkinson and Alzheimer diseases, are major biomedical challenges in need of more effective therapies. Increasing brain resilience may represent a new treatment strategy. Klotho, a longevity factor, enhances cognition whe...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2017.07.024

    authors： Leon J,Moreno AJ,Garay BI,Chalkley RJ,Burlingame AL,Wang D,Dubal DB

    更新日期：2017-08-08 00:00:00

  • The Dachsous/Fat/Four-Jointed Pathway Directs the Uniform Axial Orientation of Epithelial Cells in the Drosophila Abdomen.

    abstract：:The achievement of the final form of an individual requires not only the control of cell size and differentiation but also integrative directional cues to instruct cell movements, positions, and orientations. In Drosophila, the adult epidermis of the abdomen is created de novo by histoblasts. As these expand and fuse,...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2018.11.036

    authors： Mangione F,Martín-Blanco E

    更新日期：2018-12-04 00:00:00

  • Evolutionary Divergence of Enzymatic Mechanisms for Tubulin Detyrosination.

    abstract：:The two related members of the vasohibin family, VASH1 and VASH2, encode human tubulin detyrosinases. Here we demonstrate that, in contrast to VASH1, which requires binding of small vasohibin binding protein (SVBP), VASH2 has autonomous tubulin detyrosinating activity. Moreover, we demonstrate that SVBP acts as a bona...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2019.11.074

    authors： van der Laan S,Lévêque MF,Marcellin G,Vezenkov L,Lannay Y,Dubra G,Bompard G,Ovejero S,Urbach S,Burgess A,Amblard M,Sterkers Y,Bastien P,Rogowski K

    更新日期：2019-12-17 00:00:00

  • High-throughput screening for bioactive molecules using primary cell culture of transgenic zebrafish embryos.

    abstract：:Transgenic zebrafish embryos expressing tissue-specific green fluorescent protein (GFP) can provide an unlimited supply of primary embryonic cells. Agents that promote the differentiation of these cells may be beneficial for therapeutics. We report a high-throughput approach for screening small molecules that regulate...

    journal_title：Cell reports

    pub_type： 杂志文章

    doi：10.1016/j.celrep.2012.08.015

    authors： Huang H,Lindgren A,Wu X,Liu NA,Lin S

    更新日期：2012-09-27 00:00:00