Abstract：
:Endogenous retroviruses (ERVs), which make up 8% of the human genome, have been proposed to participate in the control of gene regulatory networks. In this study, we find a region- and developmental stage-specific expression pattern of ERVs in the developing human brain, which is linked to a transcriptional network based on ERVs. We demonstrate that almost 10,000, primarily primate-specific, ERVs act as docking platforms for the co-repressor protein TRIM28 in human neural progenitor cells, which results in the establishment of local heterochromatin. Thereby, TRIM28 represses ERVs and consequently regulates the expression of neighboring genes. These results uncover a gene regulatory network based on ERVs that participates in control of gene expression of protein-coding transcripts important for brain development.
journal_name
Cell Repjournal_title
Cell reportsauthors
Brattås PL,Jönsson ME,Fasching L,Nelander Wahlestedt J,Shahsavani M,Falk R,Falk A,Jern P,Parmar M,Jakobsson Jdoi
10.1016/j.celrep.2016.12.010subject
Has Abstractpub_date
2017-01-03 00:00:00pages
1-11issue
1issn
2211-1247pii
S2211-1247(16)31683-7journal_volume
18pub_type
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