Abstract：
:HIV-1 is transmitted between T cells through the release of cell-free particles and through cell-cell contact. Cell-to-cell transmission is more efficient than cell-free virus transmission, mediates resistance to immune responses, and facilitates the spread of virus among T cells. However, whether HIV cell-to-cell transmission influences the establishment of HIV-1 latency has not been carefully explored. We developed an HIV-1 latency model based on the transmission of HIV-1 directly to resting CD4+ T cells by cell-cell contact. This model recapitulates the spread of HIV-1 in T-cell-dense anatomical compartments. We demonstrate that productively infected activated CD4+ T cells transmit HIV-1 to resting CD4+ T cells in a cell-contact-dependent manner. However, proviruses generated in this fashion are more difficult to induce compared to proviruses generated by cell-free infection, suggesting that cell-to-cell transmission influences the establishment and maintenance of latent infection in resting CD4+ T cells.
journal_name
Cell Repjournal_title
Cell reportsauthors
Agosto LM,Herring MB,Mothes W,Henderson AJdoi
10.1016/j.celrep.2018.07.079subject
Has Abstractpub_date
2018-08-21 00:00:00pages
2088-2100issue
8issn
2211-1247pii
S2211-1247(18)31197-5journal_volume
24pub_type
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