Abstract：
:Reactive astrogliosis is an essential and ubiquitous response to CNS injury, but in some cases, aberrant activation of astrocytes and their release of inhibitory signaling molecules can impair endogenous neural repair processes. Our lab previously identified a secreted intercellular signaling molecule, called endothelin-1 (ET-1), which is expressed at high levels by reactive astrocytes in multiple sclerosis (MS) lesions and limits repair by delaying oligodendrocyte progenitor cell (OPC) maturation. However, as ET receptors are widely expressed on neural cells, the cell- and receptor-specific mechanisms of OPC inhibition by ET-1 action remain undefined. Using pharmacological approaches and cell-specific endothelin receptor (EDNR) ablation, we show that ET-1 acts selectively through EDNRB on astrocytes--and not OPCs--to indirectly inhibit remyelination. These results demonstrate that targeting specific pathways in reactive astrocytes represents a promising therapeutic target in diseases with extensive reactive astrogliosis, including MS.
journal_name
Cell Repjournal_title
Cell reportsauthors
Hammond TR,McEllin B,Morton PD,Raymond M,Dupree J,Gallo Vdoi
10.1016/j.celrep.2015.11.002subject
Has Abstractpub_date
2015-12-15 00:00:00pages
2090-7issue
10issn
2211-1247pii
S2211-1247(15)01289-9journal_volume
13pub_type
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