Decoding the Transcriptional Response to Ischemic Stroke in Young and Aged Mouse Brain.

abstract：:In many organs, stem cell function depends on communication with their niche partners. Cranial sensory neurons develop in close proximity to blood vessels; however, whether vasculature is an integral component of their niches is yet unknown. Here, two separate roles for vasculature in cranial sensory neurogenesis in z...

journal_title：Cell reports

authors： Taberner L,Bañón A,Alsina B

更新日期：2020-07-14 00:00:00

abstract：:Early lineage-specific master regulators are essential for the specification of cell types. However, once cells are committed to a specific fate, it is critical to restrict the activity of such factors to enable differentiation. To date, it remains unclear how these factors are silenced. Using the Drosophila mesoderm ...

journal_title：Cell reports

authors： Domsch K,Schröder J,Janeschik M,Schaub C,Lohmann I

更新日期：2021-01-05 00:00:00

abstract：:Repair Schwann cells play a critical role in orchestrating nerve repair after injury, but the cellular and molecular processes that generate them are poorly understood. Here, we perform a combined whole-genome, coding and non-coding RNA and CpG methylation study following nerve injury. We show that genes involved in t...

journal_title：Cell reports

authors： Arthur-Farraj PJ,Morgan CC,Adamowicz M,Gomez-Sanchez JA,Fazal SV,Beucher A,Razzaghi B,Mirsky R,Jessen KR,Aitman TJ

更新日期：2017-09-12 00:00:00

abstract：:At presynaptic active zones, exocytosis of neurotransmitter vesicles (SVs) is driven by SNARE complexes that recruit Syb2 and SNAP25. However, it remains unknown which SNAREs promote the secretion of neuronal proteins, including those essential for circuit development and experience-dependent plasticity. Here we demon...

journal_title：Cell reports

authors： Shimojo M,Courchet J,Pieraut S,Torabi-Rander N,Sando R 3rd,Polleux F,Maximov A

更新日期：2015-05-19 00:00:00

abstract：:It is currently assumed that 3D chromosomal organization plays a central role in transcriptional control. However, depletion of cohesin and CTCF affects the steady-state levels of only a minority of transcripts. Here, we use high-resolution Capture Hi-C to interrogate the dynamics of chromosomal contacts of all annota...

journal_title：Cell reports

authors： Thiecke MJ,Wutz G,Muhar M,Tang W,Bevan S,Malysheva V,Stocsits R,Neumann T,Zuber J,Fraser P,Schoenfelder S,Peters JM,Spivakov M

更新日期：2020-07-21 00:00:00

abstract：:A better understanding of the impact of antibiotics on bacteria is required to increase the efficiency of antibiotic treatments and to slow the emergence of resistance. Using Escherichia coli, we examined how bacteria exposed to sublethal concentrations of ampicillin adjust gene expression patterns and metabolism to s...

journal_title：Cell reports

authors： Mathieu A,Fleurier S,Frénoy A,Dairou J,Bredeche MF,Sanchez-Vizuete P,Song X,Matic I

更新日期：2016-09-27 00:00:00

abstract：:The large number of mutations identified across all cancers represents an untapped reservoir of targets that can be useful for therapeutic targeting if highly selective, mutation-specific reagents are available. We report here our attempt to generate such reagents: monoclonal antibodies against the most common R175H, ...

journal_title：Cell reports

authors： Hwang LA,Phang BH,Liew OW,Iqbal J,Koh XH,Koh XY,Othman R,Xue Y,Richards AM,Lane DP,Sabapathy K

更新日期：2018-01-02 00:00:00

abstract：:Zika virus (ZIKV) is an emerging, mosquito-borne flavivirus responsible for recent epidemics across the Americas, and it is closely related to dengue virus (DENV). Here, we study samples from 46 DENV-naive and 43 DENV-immune patients with RT-PCR-confirmed ZIKV infection at early-acute, late-acute, and convalescent tim...

journal_title：Cell reports

authors： Michlmayr D,Kim EY,Rahman AH,Raghunathan R,Kim-Schulze S,Che Y,Kalayci S,Gümüş ZH,Kuan G,Balmaseda A,Kasarskis A,Wolinsky SM,Suaréz-Fariñas M,Harris E

更新日期：2020-04-28 00:00:00

abstract：:The CARMA1/CARD11-BCL10-MALT1 (CBM) complex bridges T and B cell antigen receptor (TCR/BCR) ligation to MALT1 protease activation and canonical nuclear factor κB (NF-κB) signaling. Using unbiased mass spectrometry, we discover multiple serine phosphorylation sites in the MALT1 C terminus after T cell activation. Phosp...

journal_title：Cell reports

authors： Gehring T,Erdmann T,Rahm M,Graß C,Flatley A,O'Neill TJ,Woods S,Meininger I,Karayel O,Kutzner K,Grau M,Shinohara H,Lammens K,Feederle R,Hauck SM,Lenz G,Krappmann D

更新日期：2019-10-22 00:00:00

abstract：:Adipocytes deficient in fatty acid synthase (iAdFASNKO) emit signals that mimic cold exposure to enhance the appearance of thermogenic beige adipocytes in mouse inguinal white adipose tissues (iWATs). Both cold exposure and iAdFASNKO upregulate the sympathetic nerve fiber (SNF) modulator Neuregulin 4 (Nrg4), activate ...

journal_title：Cell reports

authors： Henriques F,Bedard AH,Guilherme A,Kelly M,Chi J,Zhang P,Lifshitz LM,Bellvé K,Rowland LA,Yenilmez B,Kumar S,Wang Y,Luban J,Weinstein LS,Lin JD,Cohen P,Czech MP

更新日期：2020-08-04 00:00:00

abstract：:Iron metabolism is regulated by transcriptional and post-transcriptional mechanisms. The mRNA of the iron-controlling gene, transferrin receptor 1 (TfR1), has long been believed to be negatively regulated by a yet-unidentified endonuclease. Here, we show that the endonuclease Regnase-1 is critical for the degradation ...

journal_title：Cell reports

authors： Yoshinaga M,Nakatsuka Y,Vandenbon A,Ori D,Uehata T,Tsujimura T,Suzuki Y,Mino T,Takeuchi O

更新日期：2017-05-23 00:00:00

abstract：:Dietary nutrients interact with gene networks to orchestrate adaptive responses during metabolic stress. Here, we identify Baf60a as a diet-sensitive subunit of the SWI/SNF chromatin-remodeling complexes in the mouse liver that links the consumption of fat- and cholesterol-rich diet to elevated plasma cholesterol leve...

journal_title：Cell reports

authors： Meng ZX,Wang L,Chang L,Sun J,Bao J,Li Y,Chen YE,Lin JD

更新日期：2015-11-24 00:00:00

abstract：:The innate immune system senses cytosolic dsDNA and bacterial cyclic dinucleotides and initiates signaling via the adaptor STING to induce type 1 interferon (IFN) response. We demonstrate here that BTK-deficient cells have impaired IFN-β production and TBK1/IRF3 activation when stimulated with agonists or infected wit...

journal_title：Cell reports

authors： Lee KG,Kim SS,Kui L,Voon DC,Mauduit M,Bist P,Bi X,Pereira NA,Liu C,Sukumaran B,Rénia L,Ito Y,Lam KP

更新日期：2015-02-24 00:00:00

abstract：:Protein isoforms generated by alternative splicing contribute to proteome diversity. Because of the lack of effective techniques, the isoform-specific function, expression, localization, and signaling of endogenous proteins are unknown for most genes. Here, we report a genetic method, isoTarget, for multi-purpose stud...

journal_title：Cell reports

authors： Liu H,Pizzano S,Li R,Zhao W,Veling MW,Hu Y,Yang L,Ye B

更新日期：2020-11-10 00:00:00

abstract：:The accumulation of damage caused by oxidative stress has been linked to aging and to the etiology of numerous age-related diseases. The longevity gene, sirtuin 6 (SIRT6), promotes genome stability by facilitating DNA repair, especially under oxidative stress conditions. Here we uncover the mechanism by which SIRT6 is...

journal_title：Cell reports

authors： Van Meter M,Simon M,Tombline G,May A,Morello TD,Hubbard BP,Bredbenner K,Park R,Sinclair DA,Bohr VA,Gorbunova V,Seluanov A

更新日期：2016-09-06 00:00:00

abstract：:Telomerase biogenesis is a complex process where several steps remain poorly understood. Single-strand-selective uracil-DNA glycosylase (SMUG1) associates with the DKC1-containing H/ACA ribonucleoprotein complex, which is essential for telomerase biogenesis. Herein, we show that SMUG1 interacts with the telomeric RNA ...

journal_title：Cell reports

authors： Kroustallaki P,Lirussi L,Carracedo S,You P,Esbensen QY,Götz A,Jobert L,Alsøe L,Sætrom P,Gagos S,Nilsen H

更新日期：2019-08-13 00:00:00

abstract：:Proper control of DNA replication is essential to ensure faithful transmission of genetic material and prevent chromosomal aberrations that can drive cancer progression and developmental disorders. DNA replication is regulated primarily at the level of initiation and is under strict cell-cycle regulation. Importantly,...

journal_title：Cell reports

authors： Nordman JT,Kozhevnikova EN,Verrijzer CP,Pindyurin AV,Andreyeva EN,Shloma VV,Zhimulev IF,Orr-Weaver TL

更新日期：2014-11-06 00:00:00

abstract：:Recent progress in single-cell technologies has enabled the identification of all major cell types in mouse. However, for most cell types, the regulatory mechanism underlying their identity remains poorly understood. By computational analysis of the recently published mouse cell atlas data, we have identified 202 regu...

journal_title：Cell reports

authors： Suo S,Zhu Q,Saadatpour A,Fei L,Guo G,Yuan GC

更新日期：2018-11-06 00:00:00

abstract：:Adrenergic receptors are highly homologous while at the same time display a wide diversity of ligand and G-protein binding, and understanding this diversity is key for designing selective or biased drugs for them. Here, we determine two crystal structures of the α2A adrenergic receptor (α2AAR) in complex with a partia...

journal_title：Cell reports

authors： Qu L,Zhou Q,Xu Y,Guo Y,Chen X,Yao D,Han GW,Liu ZJ,Stevens RC,Zhong G,Wu D,Zhao S

更新日期：2019-12-03 00:00:00

abstract：:Large cohorts of human induced pluripotent stem cells (iPSCs) from healthy donors are a potentially powerful tool for investigating the relationship between genetic variants and cellular behavior. Here, we integrate high content imaging of cell shape, proliferation, and other phenotypes with gene expression and DNA se...

journal_title：Cell reports

authors： Vigilante A,Laddach A,Moens N,Meleckyte R,Leha A,Ghahramani A,Culley OJ,Kathuria A,Hurling C,Vickers A,Wiseman E,Tewary M,Zandstra PW,HipSci Consortium.,Durbin R,Fraternali F,Stegle O,Birney E,Luscombe NM,Danovi D,

更新日期：2019-02-19 00:00:00

abstract：:Cytoplasmic long non-coding RNAs have been shown to act at many different levels to control post-transcriptional gene expression, although their role in translational control is poorly understood. Here, we show that lnc-31, a non-coding RNA required for myoblast proliferation, promotes ROCK1 protein synthesis by stabi...

journal_title：Cell reports

authors： Dimartino D,Colantoni A,Ballarino M,Martone J,Mariani D,Danner J,Bruckmann A,Meister G,Morlando M,Bozzoni I

更新日期：2018-04-17 00:00:00

abstract：:Fc receptor for IgM (FcμR)-deficient mice display dysregulated function of neutrophils, dendritic cells, and B cells. The relevance of FcμR to human T cells is still unknown. We show that FcμR is mostly stored inside the cell and that surface expression is tightly regulated. Decreased surface expression on T cells fro...

journal_title：Cell reports

authors： Meryk A,Pangrazzi L,Hagen M,Hatzmann F,Jenewein B,Jakic B,Hermann-Kleiter N,Baier G,Jylhävä J,Hurme M,Trieb K,Grubeck-Loebenstein B

更新日期：2019-03-05 00:00:00

abstract：:The development of an embryo requires precise spatiotemporal regulation of cellular processes. During Drosophila gastrulation, a precise temporal pattern of cell division is encoded through transcriptional regulation of cdc25(string) in 25 distinct mitotic domains. Using a genetic screen, we demonstrate that the same ...

journal_title：Cell reports

authors： Momen-Roknabadi A,Di Talia S,Wieschaus E

更新日期：2016-09-13 00:00:00

abstract：:Primary afferents transduce environmental stimuli into electrical activity that is transmitted centrally to be decoded into corresponding sensations. However, it remains unknown how afferent populations encode different somatosensory inputs. To address this, we performed two-photon Ca2+ imaging from thousands of dorsa...

journal_title：Cell reports

authors： Wang F,Bélanger E,Côté SL,Desrosiers P,Prescott SA,Côté DC,De Koninck Y

更新日期：2018-05-15 00:00:00

abstract：:The centromere binding factor 3 (CBF3) complex binds the third centromere DNA element in organisms with point centromeres, such as S. cerevisiae. It is an essential complex for assembly of the kinetochore in these organisms, as it facilitates genetic centromere specification and allows association of all other kinetoc...

journal_title：Cell reports

authors： Zhang W,Lukoyanova N,Miah S,Lucas J,Vaughan CK

更新日期：2018-07-17 00:00:00

abstract：:DNA double-strand break repair by homologous recombination entails the resection of DNA ends to reveal ssDNA tails, which are used to invade a homologous DNA template. CtIP and its yeast ortholog Sae2 regulate the nuclease activity of MRE11 in the initial stage of resection. Deletion of CtIP in the mouse or SAE2 in ye...

journal_title：Cell reports

authors： Daley JM,Jimenez-Sainz J,Wang W,Miller AS,Xue X,Nguyen KA,Jensen RB,Sung P

更新日期：2017-10-10 00:00:00

abstract：:Uveal melanoma (UM) is characterized by mutually exclusive activating mutations in GNAQ, GNA11, CYSLTR2, and PLCB4, four genes in a linear pathway to activation of PLCβ in almost all tumors and loss of BAP1 in the aggressive subset. We generated mice with melanocyte-specific expression of GNA11Q209L with and without h...

journal_title：Cell reports

authors： Moore AR,Ran L,Guan Y,Sher JJ,Hitchman TD,Zhang JQ,Hwang C,Walzak EG,Shoushtari AN,Monette S,Murali R,Wiesner T,Griewank KG,Chi P,Chen Y

更新日期：2018-02-27 00:00:00

abstract：:We have previously found that UV irradiation promotes RNA polymerase II (RNAPII) hyperphosphorylation and subsequent changes in alternative splicing (AS). We show now that UV-induced DNA damage is not only necessary but sufficient to trigger the AS response and that photolyase-mediated removal of the most abundant cla...

journal_title：Cell reports

authors： Muñoz MJ,Nieto Moreno N,Giono LE,Cambindo Botto AE,Dujardin G,Bastianello G,Lavore S,Torres-Méndez A,Menck CFM,Blencowe BJ,Irimia M,Foiani M,Kornblihtt AR

更新日期：2017-03-21 00:00:00

abstract：:Wiskott-Aldrich syndrome protein (WASp) is a main cytoskeletal regulator in B cells. WASp-interacting protein (WIP) binds to and stabilizes WASp but also interacts with actin. Using mice with a mutated actin binding domain of WIP (WIPΔABD), we here investigated the role of WIP binding to actin during B cell activation...

journal_title：Cell reports

authors： Keppler SJ,Burbage M,Gasparrini F,Hartjes L,Aggarwal S,Massaad MJ,Geha RS,Bruckbauer A,Batista FD

更新日期：2018-07-17 00:00:00

abstract：:Pre-implantation embryo development is an intricate and precisely regulated process orchestrated by maternally inherited proteins and newly synthesized proteins following zygotic genome activation. Although genomic and transcriptomic studies have enriched our understanding of the genetic programs underlying this proce...

journal_title：Cell reports

authors： Gao Y,Liu X,Tang B,Li C,Kou Z,Li L,Liu W,Wu Y,Kou X,Li J,Zhao Y,Yin J,Wang H,Chen S,Liao L,Gao S

更新日期：2017-12-26 00:00:00